Electrospraying as a suitable method for nanoencapsulation of the hydrophilic bioactive dihydrochalcone, aspalathin

Human, Chantelle; Beer, Dalene de; Rijst, Marieta van der; Aucamp, Marique; Joubert, Elizabeth

doi:10.1016/j.foodchem.2018.10.016

Cited by 37 publications

(8 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lecithins are commonly used as emulsifiers, to modify the viscosity of fluids, such as melted chocolate, and as a processing aid (Nieuwenhuyzen & Tomás, 2008). Current research topics using lecithins include their use as encapsulating nutrients or pharmaceuticals in a lecithin-based mixture (Human et al, 2019), creating organogels with vegetable oils (Sato, 2018), and to control crystallization. The effects of lecithin on lipid crystallization shows that lecithins do not influence the solid fat content of nontrans fat spreads with confectionary application, but they do influence the viscoelastic properties specifically increasing the elastic properties (Lončarević et al, 2013).…”

Section: According To the Us Code Of Federal Regulations (Cfr) Title mentioning

confidence: 99%

Retardation of Crystallization through the Addition of Dairy Phospholipids

Cooper

Simons

Martini

2019

J Americ Oil Chem Soc

View full text Add to dashboard Cite

show abstract

Section: According To the Us Code Of Federal Regulations (Cfr) Title mentioning

confidence: 99%

Retardation of Crystallization through the Addition of Dairy Phospholipids

Cooper

Simons

Martini

2019

J Americ Oil Chem Soc

View full text Add to dashboard Cite

show abstract

“…GRAF containing ca. 40% aspalathin (m/m) was prepared as described previously (De Beer et al, 2015) and detailed in Human et al (2019) from green rooibos plant material harvested from an experimental plantation (Barrydale, Western Cape, South Africa). Briefly, shoots were dried intact at 30 • C, followed by separation of the leaves from the stems and finely ground with a Retsch mill (1 mm sieve, Retsch GmbH, Haan, Germany).…”

Section: Preparation Of Graf and Aspalathin For Nanoencapsulationmentioning

confidence: 99%

“…A previous study from our research group compared conventional techniques and electrospraying with natural and synthetic polymers for their suitability to produce nanoparticles loaded with an aspalathin‐rich fraction prepared from green rooibos (40% aspalathin, m/m; GRAF) (Human et al., 2019). Electrospraying of GRAF and ES100 produced nanoparticles having a combination of the most favorable properties in terms of particle size, zeta potential, encapsulation efficiency (EE), loading capacity (LC), and sustained release profile at pH 7.4.…”

Section: Introductionmentioning

confidence: 99%

Effect of electrospraying conditions on the properties of aspalathin‐Eudragit S100 nanoparticles and assessment of orogastrointestinal stability and membrane permeability

et al. 2022

Self Cite

View full text Add to dashboard Cite

Aspalathin, a C-glucosyl dihydrochalcone, could have beneficial effects in the gut through the modulation of the microbiome. However, aspalathin is susceptible to oxidative degradation. The effect of electrospraying conditions on encapsulation of an aspalathin-rich fraction prepared from green rooibos (GRAF; 40% aspalathin, m/m) with Eudragit S100 (ES100), a pH-sensitive release polymer, was investigated to enhance the stability of aspalathin. Electrospraying conditions were varied according to a central composite design, using ES100 concentrations of 1-6% (m/m), GRAF concentrations of 5-25% (m/m, relative to polymer concentration), and voltages of 10-25 kV. The varying conditions produced nanoparticles ranging in yield (60.3-83.7%), encapsulation efficiency, (20.5-81.8%), loading capacity (1.0-14.9%), particle size (183-260 nm), and polydispersity index (0.35-0.74). The GRAF nanoparticles and nanoparticles prepared with pure aspalathin were evaluated for stability and release of aspalathin at fixed pH-time combinations (pH 6.8, 5 min; pH 2, 120 min; pH 4, 60 min; and pH 7, 120 min), simulating the pH and residence/transit time at various locations of the orogastrointestinal tract. Nanoencapsulation decreased aspalathin degradation at all pH-time combinations (1.9-2.7 times less degradation; p < 0.05), except for pH 7, 120 min (p ≥ 0.05), thus offering protection from the pH of the upper gastrointestinal tract. Additionally, the parallel artificial membrane permeability assay and the Caco-2 monolayer model indicated that the low membrane permeability of aspalathin after nanoencapsulation was maintained that would limit absorption, ideal for delivery in the gut. Thus, nanoencapsulated aspalathin holds potential for the regulation of gut microbiota.

show abstract

“…The potential benefits attributed to their intake may therefore be hampered by poor bioavailability and also affect their maximal efficacy. Recently, the use of nanoencapsulation methods have been explored in order to increase the bioavailability and stability of aspalathin which could possibly promote the use of more effective nutraceuticals [59]. Since fermentation reduces polyphenol content, a number of studies have explored the benefits of unfermented, green rooibos or so called aspalathin rich extracts of rooibos in an attempt to elucidate the health promoting properties of the tisane [60,61].…”

Section: Polyphenols That May Be Responsible For Beneficial Effectsmentioning

confidence: 99%

Rooibos (Aspalathus linearis) and Honeybush (Cyclopiaspp.): From Bush Teas to Potential Therapy for Cardiovascular Disease

Windvogel¹

2020

Nutraceuticals - Past, Present and Future

View full text Add to dashboard Cite

Cardiovascular disease (CVD) is a leading cause of worldwide deaths. A number of risk factors for cardiovascular disease as well as type 2 diabetes and stroke present as the metabolic syndrome. Metabolic risk factors include hypertension, abdominal obesity, dyslipidaemia and increased blood glucose levels and may also include risk factors such as vascular dysfunction, insulin resistance, low high density lipoprotein (HDL) cholesterol levels and inflammation. Rooibos (Aspalathus linearis) and honeybush (Cyclopia spp.) are indigenous South African plants whose reported health benefits include anti-tumour, anti-inflammatory, anti-obesity, antioxidant, cardioprotective and anti-diabetic properties. The last two decades have seen worldwide interest and success for these plants, not only as health beverages but also as preservatives, flavourants and skincare products. This review will focus on the current literature supporting the function of these plants as nutraceuticals capable of potentially reducing the risk of cardiovascular disease.

show abstract

Electrospraying as a suitable method for nanoencapsulation of the hydrophilic bioactive dihydrochalcone, aspalathin

Cited by 37 publications

References 36 publications

Retardation of Crystallization through the Addition of Dairy Phospholipids

Retardation of Crystallization through the Addition of Dairy Phospholipids

Effect of electrospraying conditions on the properties of aspalathin‐Eudragit S100 nanoparticles and assessment of orogastrointestinal stability and membrane permeability

Rooibos (Aspalathus linearis) and Honeybush (Cyclopiaspp.): From Bush Teas to Potential Therapy for Cardiovascular Disease

Contact Info

Product

Resources

About