Electrosprayed polyelectrolyte complexes between mucoadhesive N,N,N,-trimethylchitosan-homocysteine thiolactone and alginate/carrageenan for camptothecin delivery

Juntapram, Kotchakorn; Praphairaksit, Nalena; Siraleartmukul, Kritsana; Muangsin, Nongnuj

doi:10.1016/j.carbpol.2012.07.017

Cited by 47 publications

(9 citation statements)

References 47 publications

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“…Further investigation indicated the generation of open channel-like structures in hydrogels after exposure to pH 1.2, either for clarithromycin or repaglinide loading [24,25]. In contrast to the former strategy, another interesting study combined chitosan with anionic polymer to form cationic complexes for pH-triggered controlled release in the stomach [26]. By mixing the N,N,Ntrimethyl chitosan-homocysteine thiolactone (TMCT) solution with 3% CaCl 2 alginate solution at the appropriate ratio, camptothecin was loaded into the cationic complexes.…”

Section: Platforms Directed To the Stomachmentioning

confidence: 95%

The design of pH-sensitive chitosan-based formulations for gastrointestinal delivery

Liu

Yang

et al. 2015

Drug Discovery Today

138

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Section: Platforms Directed To the Stomachmentioning

confidence: 95%

The design of pH-sensitive chitosan-based formulations for gastrointestinal delivery

Liu

Yang

et al. 2015

Drug Discovery Today

138

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“…In this study, the periodic acid Schiff's (PAS) colorimetric assay was used as previously reported (Saboktakin et al, 2011;Juntapram et al, 2012) for the determination of the free mucin concentration, so as to evaluate the amount of mucin adsorbed onto the test cellulose and its derivatives. Mucoadhesiveness was calculated as the amount of mucin adsorbed by 10 mg of cellulose and modified cellulose in five different buffers of broadly similar ionic strength but with different pH values of 1.2, 6.8 and 7.4.…”

Section: In Vitro Bioadhesion Of Mucin On Cellulose and Modified Cellmentioning

confidence: 99%

Mucoadhesive drug carrier based on functional-modified cellulose as poorly water-soluble drug delivery system

Songsurang¹,

Siraleartmukul²,

Muangsin³

2015

Journal of Microencapsulation

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The purpose of this study was to design and characterise an oral mucoadhesive micellar drug carrier. In this regard, a mucoadhesive hydrophobic cationic aminocellulose was easily synthesised under mild homogeneous conditions with high yield. The cellulose derivative resulted in strongly improved mucoadhesive properties but was pH dependent. Furthermore, the hydrophobic anticancer drug camptothecin was successfully encapsulated into the mucoadhesive cellulose derivative micelles with spherical shape stability of 233 nm in diameter and low particle size distribution. The CPT-loaded nanocarriers provided high encapsulation efficiency about 86.4%. In vitro release, CPT-loaded cellulose derivative micelles showed a reduction in release rate compared with physically pure CPT solution. The release results also indicated that a sustained release of CPT to >80% over 4 d for pH 6.8 and 7.4. Therefore, mucoadhesive hydrophobic cationic aminocellulose micelles seem to be a promising carrier for various pharmaceutical applications especially for poorly water-soluble drug delivery system.

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“…Since an EHDA device offers the possibility of using a liquid-phase particle-collecting medium, it would be beneficial for stabilization of electrosprayed particle suspension, 31,37 and for further particle-surface modifications, such as coating 38,39 and cross-linking. 30,40,64 Almería et al reported the application of PVA in deionized water as the collecting medium whereby, PVA uniformly coated the PLGA drug-containing particles by binding onto the PLGA surface. 38 Electrospraying was also applied for preparation of cross-linked doxycycline-loaded chitosan (CS) nanoparticles using tripolyphosphate, a biocompatible cross-linking agent.…”

Section: Electrosprayingmentioning

confidence: 99%

Advances in drug delivery via electrospun and electrosprayed nanomaterials

Zamani¹,

Prabhakaran²,

Ramakrishna³

2013

IJN

201

104

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Electrohydrodynamic (EHD) techniques refer to procedures that utilize electrostatic forces to fabricate fibers or particles of different shapes with sizes in the nano-range to a few microns through electrically charged fluid jet. Employing different techniques, such as blending, surface modification, and coaxial process, there is a great possibility of incorporating bioactive such molecules as drugs, DNA, and growth factors into the nanostructures fabricated via EHD techniques. By careful selection of materials and processing conditions, desired encapsulation efficiency as well as preserved bioactivity of the therapeutic agents can be achieved. The drug-loaded nanostructures produced can be applied via different routes, such as implantation, injection, and topical or oral administration for a wide range of disease treatment. Taking advantage of the recent developments in EHD techniques like the coaxial process or multilayered structures, individually controlled delivery of multiple drugs is achievable, which is of great demand in cancer therapy and growth-factor delivery. This review summarizes the most recent techniques and postmodification methods to fabricate electrospun nanofibers and electrosprayed particles for drug-delivery applications.

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Electrosprayed polyelectrolyte complexes between mucoadhesive N,N,N,-trimethylchitosan-homocysteine thiolactone and alginate/carrageenan for camptothecin delivery

Cited by 47 publications

References 47 publications

The design of pH-sensitive chitosan-based formulations for gastrointestinal delivery

The design of pH-sensitive chitosan-based formulations for gastrointestinal delivery

Mucoadhesive drug carrier based on functional-modified cellulose as poorly water-soluble drug delivery system

Advances in drug delivery via electrospun and electrosprayed nanomaterials

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