Electrosprayed mesoporous particles for improved aqueous solubility of a poorly water soluble anticancer agent: in vitro and ex vivo evaluation

Sayed, Elshaimaa; Karavasili, Christina; Ruparelia, Ketan C.; Haj‐Ahmad, Rita; Charalambopoulou, Georgia; Steriotis, Theodore; Giasafaki, Dimitra; Cox, Paul A.; Singh, Neenu; Giassafaki, Lefki Pavlina N.; Mpenekou, Aggeliki; Markopoulou, Catherine K.; Vizirianakis, Ioannis S.; Chang, Ming Wei; Fatouros, Dimitrios G.; Ahmad, Zeeshan

doi:10.1016/j.jconrel.2018.03.031

Cited by 64 publications

(50 citation statements)

References 63 publications

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“…When HAPs were further processed by loading and coating, high percentages of weight loss were measured because of decomposition of the organic compounds Pip, GA, and FA. In this context, we can calculate the drug-loaded content in inorganic nanoparticles [62]. Pip shifted to the non-crystalline state, as the peak indicating its melting point was not observed in all loaded nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

et al. 2020

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Targeted drug delivery offers great opportunities for treating cancer. Here, we developed a novel anticancer targeted delivery system for piperine (Pip), an alkaloid prodrug derived from black pepper that exhibits anticancer effects. The tailored delivery system comprises aggregated hydroxyapatite nanoparticles (HAPs) functionalized with phosphonate groups (HAP-Ps). Pip was loaded into HAPs and HAP-Ps at pH 7.2 and 9.3 to obtain nanoformulations. The nanoformulations were characterized using several techniques and the release kinetics and anticancer effects investigated in vitro. The Pip loading capacity was >20%. Prolonged release was observed with kinetics dependent on pH, surface modification, and coating. The nanoformulations fully inhibited monolayer HCT116 colon cancer cells compared to Caco2 colon cancer and MCF7 breast cancer cells after 72 h, whereas free Pip had a weaker effect. The nanoformulations inhibited ~60% in HCT116 spheroids compared to free Pip. The Pip-loaded nanoparticles were also coated with gum Arabic and functionalized with folic acid as a targeting ligand. These functionalized nanoformulations had the lowest cytotoxicity towards normal WI-38 fibroblast cells. These preliminary findings suggest that the targeted delivery system comprising HAP aggregates loaded with Pip, coated with gum Arabic, and functionalized with folic acid are a potentially efficient agent against colon cancer.

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Section: Discussionmentioning

confidence: 99%

Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

et al. 2020

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“…Conventional FMs (wash off or peel off) are usually applied to the face and left for 15-20 min to take effect. The rapid release shown here would be beneficial for this period; especially with FMs loaded with an active cosmeceutical [13].…”

Section: Release Studiesmentioning

confidence: 99%

“…This process enables sensitive materials to be encapsulated within a polymeric fibrous matrix in a simple, one-step cost effective process [11]. It has already shown great promise in various pharmaceutical [12][13][14][15][16], food applications [17,18] and has recently gained interest in the cosmetic industry in perfumery [19,20] and FMs. For example, Camerlo et al [21] demonstrated the sustained release of limonene oil over 15 days by developing electrospun PVA fibers.…”

Section: Introductionmentioning

confidence: 99%

Engineering optimisation of commercial facemask formulations capable of improving skin moisturisation

Mehta

Picken

White

et al. 2019

Intern J of Cosmetic Sci

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Introduction The stratum corneum is the biggest obstacle in cosmetics with respect to skin moisturisation. Many approaches have been taken to overcome the barrier, one of which is incorporating natural cosmeceuticals into cosmetic products to enhance moisturisation effects. Here, a commercial facemask formulation was electrospun to develop dry facemasks capable of hosting cosmeceuticals within the pores of incorporated mesoporous silica. Methods Ethanolic solutions containing 40% w/w of the marketed facemask (7th Heaven Dead Sea peel‐off facemask) and mesoporous silica were prepared and electrically processed at 30 μL min−1 at an applied voltage of 12 ± 2 kV. In vitro characterisation and release studies using fluorescein dye as a model probe were carried out. Results SEM images confirmed the fibrous nature of the resulting matrix; showing an average fiber diameter of 298.32 nm. The electrospun mask was found to be advantageous due to this fibrous nature providing high active loading capacity whilst demonstrating 100% probe release within 60 min. Contact Angle hysteresis, thermal analysis and Fourier Transform Infrared Spectroscopy (FTIR) presented evidence of compatibility and stability of and within the formulation. Conclusion Adapting the formulation of a commercial polymeric facemask into an electrospun facemask has shown the versatility of the electrospinning process; now successfully crossing over into the cosmetic industry.

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“…Hence, the EHDA working fluids can be divided into different classes: those which cannot be processed due to clogging of the spinneret (resulting from an extremely higher concentration), electrospinnable (often within a suitable concentration range), unspinnable but solidifiable (solid particles), and unsolidifiable (no solid product) when extremely dilute solutions are used [20,21]. In the simplest monoaxial EHDA process, the active ingredients can be encapsulated directly into polymers and also inorganic materials in one step [22,23]. In multiple-liquid EHDA processes, which are employed to create complex nanostructures, the possibilities are further expanded.…”

Section: Introductionmentioning

confidence: 99%

Immediate release of helicid from nanoparticles produced by modified coaxial electrospraying

Zheng

Yang

et al. 2019

Applied Surface Science

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In this paper, a modified coaxial electrospraying process was explored for the generation of novel nanoscale composite materials. A solution comprising 5% (w/v) of the model drug helicid and 10% (w/v) polyvinylpyrrolidone (PVP) K10 in a mixture of N,N-dimethylacetamide and ethanol (4:6, v:v) was employed as the shell working liquid.This could not be processed into a solid product when processed by single-fluid electrospraying. However, when undertaking co-axial electrospraying with a core shellac solution (40% w/v in ethanol) solid particles were obtained. An extremely thin nanocoating layer of drug-polymer composite with an estimated thickness of 7 nm was deposited on a shellac core. X-ray diffraction and infrared spectroscopy demonstrated that the drug was converted into an amorphous nanocomposite with the PVP in the shell layer, losing its original crystalline state. In vitro dissolution tests revealed that all the helicid loading could be released within one minute, suggesting the particles have potential applications to deliver very rapid therapeutic effects. Mechanisms are proposed underlying the formation and functional performance of the materials.

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Electrosprayed mesoporous particles for improved aqueous solubility of a poorly water soluble anticancer agent: in vitro and ex vivo evaluation

Cited by 64 publications

References 63 publications

Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

Engineering optimisation of commercial facemask formulations capable of improving skin moisturisation

Immediate release of helicid from nanoparticles produced by modified coaxial electrospraying

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