Electrosprayed Core–Shell Composite Microbeads Based on Pectin-Arabinoxylans for Insulin Carrying: Aggregation and Size Dispersion Control

Rascón‐Chu, Agustín; Díaz-Baca, Jonathan A; Carvajal-Millán, Elizabeth; Pérez-López, Elías; Hotchkiss, Arland T.; González‐Ríos, Humberto; Balandrán‐Quintana, René Renato; Campa-Mada, Alma C.

doi:10.3390/polym10020108

Cited by 22 publications

(21 citation statements)

References 31 publications

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“…AXM were prepared by coaxial electrospraying method (The Spraybase ® electrospray device, Profector Life Sciences, Kildare, Ireland) according to Rascón-Chu et al [32] with some modifications. Figure 2 shows a schematic representation of the coaxial electrospraying setup used to prepare the AXM.…”

Section: Methodsmentioning

confidence: 99%

Arabinoxylan-Based Particles: In Vitro Antioxidant Capacity and Cytotoxicity on a Human Colon Cell Line

Méndez-Encinas¹,

Carvajal-Millán²,

Rascón‐Chu³

et al. 2019

Medicina

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Background and objectives: Arabinoxylans (AX) can gel and exhibit antioxidant capacity. Previous studies have demonstrated the potential application of AX microspheres as colon-targeted drug carriers. However, the cytotoxicity of AX gels has not been investigated so far. Therefore, the aim of the present study was to prepare AX-based particles (AXM) by coaxial electrospraying method and to investigate their antioxidant potential and cytotoxicity on human colon cells. Materials and Methods: The gelation of AX was studied by monitoring the storage (G′) and loss (G′′) moduli. The morphology of AXM was evaluated using optical and scanning electron microscopy (SEM). The in vitro antioxidant activity of AX before and after gelation was measured using the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) methods. In addition, the effect of AX and AXM on the proliferation of human colon cells (CCD 841 CoN) was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results: The final G′ and G′′ values for AX gels were 293 and 0.31 Pa, respectively. AXM presented spherical shape and rough surface with a three-dimensional and porous network. The swelling ratio and mesh size of AXM were 35 g water/g AX and 27 nm, respectively. Gelation decreased the antioxidant activity of AX by 61–64 %. AX and AXM did not affect proliferation or show any toxic effect on the normal human colon cell line CCD 841 CoN. Conclusion: The results indicate that AXM could be promising biocompatible materials with antioxidant activity.

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Section: Methodsmentioning

confidence: 99%

Arabinoxylan-Based Particles: In Vitro Antioxidant Capacity and Cytotoxicity on a Human Colon Cell Line

Méndez-Encinas¹,

Carvajal-Millán²,

Rascón‐Chu³

et al. 2019

Medicina

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“…These authors proposed these polysaccharides system as a suitable candidate for the release of insulin under oral administration. In addition, Rascón-Chu et al [ 149 ] proposed a pectin-arabinoxylans composite microbead for insulin carrying. The characteristics presented in the structure of the polymers rendered small and stable particle sizes without aggregation or coalescence for all of the treatment evaluated, but few with little size dispersion that may allow the controlled delivery of insulin consistently.…”

Section: Potential Applications Of Pectin In Pharmaceutical and Bimentioning

confidence: 99%

“…Nevertheless, some studies have been carried out for the evaluation of microspheres composed of pectin and arabinoxylans. For instance, Rascón-Chu et al [ 149 ] evaluated the optimization of manufacturing parameters for core-shell type microspheres based on pectin/arabinoxylans, for encapsulation of insulin by coaxial electrospray method ( Figure 11 ).…”

Section: Pectin Compositesmentioning

confidence: 99%

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Pectin and Pectin-Based Composite Materials: Beyond Food Texture

et al. 2018

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Pectins are plant cell wall natural heteropolysaccharides composed mainly of α-1-4 d-galacturonic acid units, which may or may not be methyl esterified, possesses neutral sugars branching that harbor functional moieties. Physicochemical features as pH, temperature, ions concentration, and cosolute presence, affect directly the extraction yield and gelling capacity of pectins. The chemical and structural features of this polysaccharide enables its interaction with a wide range of molecules, a property that scientists profit from to form new composite matrices for target/controlled delivery of therapeutic molecules, genes or cells. Considered a prebiotic dietary fiber, pectins meetmany regulations easily, regarding health applications within the pharmaceutical industry as a raw material and as an agent for the prevention of cancer. Thus, this review lists many emergent pectin-based composite materials which will probably palliate the impact of obesity, diabetes and heart disease, aid to forestall actual epidemics, expand the ken of food additives and food products design.

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“…Correspondingly, the methods for creating core-sheath structures are always highly desired in scientific fields. This should be one of the most important reasons that coaxial electrospinning [15,16], and also coaxial electrospraying [17][18][19][20][21], are receiving the increasing attention nearly from all the applied functional material fields.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Environment Remediation Nanofibers Using Unspinnable Liquids as the Sheath Fluids: A Review

Wang

Yang

et al. 2020

Polymers

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Electrospinning, as a promising platform in multidisciplinary engineering over the past two decades, has overcome major challenges and has achieved remarkable breakthroughs in a wide variety of fields such as energy, environmental, and pharmaceutics. However, as a facile and cost-effective approach, its capability of creating nanofibers is still strongly limited by the numbers of treatable fluids. Most recently, more and more efforts have been spent on the treatments of liquids without electrospinnability using multifluid working processes. These unspinnable liquids, although have no electrospinnability themselves, can be converted into nanofibers when they are electrospun with an electrospinnable fluid. Among all sorts of multifluid electrospinning methods, coaxial electrospinning is the most fundamental one. In this review, the principle of modified coaxial electrospinning, in which unspinnable liquids are explored as the sheath working fluids, is introduced. Meanwhile, several typical examples are summarized, in which electrospun nanofibers aimed for the environment remediation were prepared using the modified coaxial electrospinning. Based on the exploration of unspinnable liquids, the present review opens a way for generating complex functional nanostructures from other kinds of multifluid electrospinning methods.

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Electrosprayed Core–Shell Composite Microbeads Based on Pectin-Arabinoxylans for Insulin Carrying: Aggregation and Size Dispersion Control

Cited by 22 publications

References 31 publications

Arabinoxylan-Based Particles: In Vitro Antioxidant Capacity and Cytotoxicity on a Human Colon Cell Line

Arabinoxylan-Based Particles: In Vitro Antioxidant Capacity and Cytotoxicity on a Human Colon Cell Line

Pectin and Pectin-Based Composite Materials: Beyond Food Texture

Electrospun Environment Remediation Nanofibers Using Unspinnable Liquids as the Sheath Fluids: A Review

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