Arabinoxylan-Based Particles: In Vitro Antioxidant Capacity and Cytotoxicity on a Human Colon Cell Line

Méndez-Encinas, Mayra A.; Carvajal-Millán, Elizabeth; Rascón‐Chu, Agustín; Astiazarán-García, Humberto; Valencia, Dora; Brown, Francisco; Alday, Efrain; Velázquez, Carlos

doi:10.3390/medicina55070349

Cited by 19 publications

(23 citation statements)

References 68 publications

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“…AX presented a FA content of 6.72 µg/mg AX, indicating a highly ferulated structure. Similar FA contents ranging from 5.45 to 7.53 µg/mg AX have been previously reported for other AX extracted from DDGS [8,10]. According to the results, the FA content in AX-1 and AX-2 was not affected by the ultrasonic treatment, indicating that the treatment was not able to release the FA residues from the polysaccharide chains.…”

Section: Ft-ir Analysissupporting

confidence: 87%

“…AX samples were recorded on a Nicolet iS50 FT-IR spectrometer (Thermo Fisher Scientific Inc., Waltham, MA, USA) in absorbance mode from 400 to 4000 cm −1 range at 20 • C. Thirty-two scans at a resolution of 4 cm −1 were averaged and referenced against air [8].…”

Section: Fourier Transform Infrared Spectroscopy Analysismentioning

confidence: 99%

“…Distiller's dried grains with solubles (DDGS), which is the main co-product from dry-grind corn ethanol production represent a good source of arabinoxylans (AX). AX are non-starch polysaccharides with antioxidant capacity [8] and a structure consisting of a linear β-(1-4)-xylose backbone with some arabinose substitutions at O-3 and/or O-2 positions. Additionally, ferulic acid (FA) residues can be ester-linked to some arabinose units at O-5 position [9].…”

Section: Introductionmentioning

confidence: 99%

“…Other components such as sugars (galactose, glucose, mannose, glucuronic acid), hydroxycinnamic acids (coumaric and sinapic acid) and protein may be part of its structure [10,11]. AX exert antioxidant ability which has been widely related to its phenolic content, mainly FA as it is the most abundant into its structure [8,12,13]. Moreover, health-promoting properties of AX such as prebiotic, anti-obesogenic, immunomodulating and antiproliferative properties have been previously documented [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Ultrasound-Treated Arabinoxylans on the Oxidative Stability of Soybean Oil

et al. 2020

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Arabinoxylans (AX) are polysaccharides with antioxidant activity and emulsifying properties, which make them an attractive alternative for its potential application as a natural antioxidant in oils. Therefore, this work aimed to investigate the effect of ultrasonic treatment of AX on their antioxidant capacity and its ability to improve the oxidative stability of soybean oil. For this purpose, AX were exposed to ultrasonic treatment at 25% (100 W, AX-1) and 50% (200 W, AX-2) power and an operating frequency of 20 KHz during 15 min, and their macromolecular properties (weight average molecular weight (Mw), polydispersity index and intrinsic viscosity) were evaluated. The antioxidant capacity of AX was determined by the DPPH assay and Rancimat test. Results showed that ultrasonic treatment did not affect the molecular identity of the polysaccharide but modified its Mw distribution. AX-1 showed the highest antioxidant activity (75% inhibition) at 533 µg/mL by the DPPH method compared to AX and AX-2. AX at 0.25% (w/v) and AX-1 at 0.01% (w/v) exerted the highest protective effects on oxidative stability of soybean oil with induction periods of 7.69 and 5.54 h, respectively. The results indicate that AX could be a good alternative for the potential application as a natural antioxidant in oils.

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Section: Ft-ir Analysissupporting

confidence: 87%

Section: Fourier Transform Infrared Spectroscopy Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Ultrasound-Treated Arabinoxylans on the Oxidative Stability of Soybean Oil

et al. 2020

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“…Thus, the polysaccharides still had a relatively high Mw; in this regard, the Mw the AXs did not seem to impact their antioxidant activity. The antioxidant capacity values obtained for the AXs and FAXs are in the range reported for other AXs from DDGS (12-68 mmol TEAC/kg) [17,38] and higher than those reported in AXs from other maize co-products (6-16 mmol TEAC/kg) [14,39]. The results suggested that AXs and FAXs have great potential as free-radical scavengers in the food, pharmaceutical, medical, and cosmetic industries, The TEAC values of AXs and FAXs are shown in Table 3, as determined by the procedures using DPPH and ABTS solutions.…”

Section: Ax and Fax Gelling And Antioxidant Propertiessupporting

confidence: 65%

Feruloylated Arabinoxylans from Maize Distiller’s Dried Grains with Solubles: Effect of Feruloyl Esterase on their Macromolecular Characteristics, Gelling, and Antioxidant Properties

Márquez-Escalante

Carvajal-Millán

2019

Sustainability

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Distiller’s dried grains with solubles (DDGS) are co-products of the maize ethanol industry. DDGS contains feruloylated arabinoxylans (AXs), which can present gelling, antioxidant, and health-promoting effects. However, AXs presenting high ferulic acid (FA) content can exhibit delayed fermentation by the colonic microbiota. Therefore, partial deferuloylation of AXs from DDGS while preserving the polysaccharide gelling and antioxidant properties could add value and favor the sustainable development of bioethanol plants. The aim of this work was to partially deferuloylated AXs from DDGS using feruloyl esterase and to evaluate the polysaccharide macromolecular characteristics, gelling, and antioxidant properties. The AXs presented FA and FA dimer contents of 3.27 and 0.30 µg/mg polysaccharide, respectively, which decreased to 1.26 and 0.20 µg/mg polysaccharide, respectively, in feruloyl esterase-treated AXs (FAXs). The molecular weight and intrinsic viscosity of FAXs were slightly less than those of AXs. The Fourier transform infrared spectroscopy data of AXs and FAXs were similar, confirming that the enzyme did not modify the polysaccharide molecular identity. FAX gels (2% w/v) exhibited a decrease in elasticity by 43% in relation to that of AXs gels. The antioxidant capacity of FAXs was reduced by 32% and 43% (DPPH and ABTS method, respectively), compared with that of AXs. The FAX gelling and antioxidant properties were -comparable to those reported for other AXs in the literature. Feruloyl esterase may offer an interesting approach for the design of functional FAXs as value-added products recovered from DDGS.

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Fine structural features and antioxidant capacity of ferulated arabinoxylans extracted from nixtamalized maize bran

et al. 2023

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BACKGROUND The nixtamalization process improves the nutritional and technological properties of maize. This process generates nixtamalized maize bran as a by‐product, which is a source of arabinoxylans (AX). AX are polysaccharides constituted of a xylose backbone with mono‐ or di‐arabinose substitutions, which can be ester‐linked to ferulic acid (FA). The present study investigated the fine structural features and antioxidant capacity (AC) of nixtamalized maize bran arabinoxylans (MBAX) to comprehend the structure–radical scavenging capacity relationship in this polysaccharide deeply. RESULTS MBAX presented a molecular weight, intrinsic viscosity, and hydrodynamic radius of 674 kDa, 1.8 dL g−1, and 24.6 nm, respectively. The arabinose‐to‐xylose ratio (A/X) and FA content were 0.74 and 0.25 g kg−1 polysaccharide, respectively. MBAX contained dimers (di‐FA) and trimer (tri‐FA) of FA (0.14 and 0.07 g kg−1 polysaccharide, respectively). The main di‐FA isomer was the 8–5′ structure (80%). Fourier transform infrared spectroscopy confirmed MBAX molecular identity, and the second derivate of the spectral data revealed a band at 958 cm−1 related to the presence of arabinose disubstitution. 1H‐Nuclear magnetic resonance spectroscopy showed mono‐ and di‐arabinose substitution in the xylan backbone with more monosubstituted residues. MBAX registered an AC of 25 and 20 μmol Trolox equivalents g−1 polysaccharide despite a low FA content, using ABTS (2,2′‐azino‐bis‐3‐ethylbenzthiazoline‐6‐sulfonic acid) and DPPH (1,1‐diphenyl‐2‐picrylhydrazyl) methods, respectively. CONCLUSION AC in MBAX could be related to the high A/X ratio (mainly monosubstitution) and the high 8–5′ di‐FA proportion in this polysaccharide. © 2023 Society of Chemical Industry.

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Arabinoxylan-Based Particles: In Vitro Antioxidant Capacity and Cytotoxicity on a Human Colon Cell Line

Cited by 19 publications

References 68 publications

Effect of Ultrasound-Treated Arabinoxylans on the Oxidative Stability of Soybean Oil

Effect of Ultrasound-Treated Arabinoxylans on the Oxidative Stability of Soybean Oil

Feruloylated Arabinoxylans from Maize Distiller’s Dried Grains with Solubles: Effect of Feruloyl Esterase on their Macromolecular Characteristics, Gelling, and Antioxidant Properties

Fine structural features and antioxidant capacity of ferulated arabinoxylans extracted from nixtamalized maize bran

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