Electrospinning porcine decellularized nerve matrix scaffold for peripheral nerve regeneration

Kong, Yan; Xu, Jiawei; Han, Qi; Zheng, Tiantian; Wu, Linliang; Li, Guicai; Yang, Yumin

doi:10.1016/j.ijbiomac.2022.04.161

Cited by 16 publications

(4 citation statements)

References 43 publications

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“…The repair effect of biological materials is determined by the composition of the material itself. [ 2 ] CM‐chitosan‐based NGCs, designed to induce the regeneration of damaged peripheral nerves without adding cells and bioactive factors, could potentially be tissue‐inducing biomaterials. [ 60 ]…”

Section: Resultsmentioning

confidence: 99%

“…[1] However, regeneration and functional recovery of defects longer than 5 mm are often incomplete because of differences in nerve structure and mismatching of Schwann cell phenotypes. [2] Without appropriate intervention, peripheral nerve injury (PNI) may lead to permanent impairment due to the irreversible loss of damaged neurons. [3] The gold standard for bridging the nerve gap is an autologous nerve graft; however, this method is limited by the lack of donor nerves and variable functional results in a clinical setting.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Facilitation of Cell Cycle and Cellular Migration of Rat Schwann Cells by O‐Carboxymethyl Chitosan to Support Peripheral Nerve Regeneration

Jiang

Zhang

Liu

et al. 2023

Macromolecular Bioscience

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O‐carboxymethyl chitosan (CM‐chitosan), holds high potential as a valuable biomaterial for nerve guidance conduits (NGCs). However, the lack of explicit bioactivity on neurocytes and poor duration that does not match nerve repair limit the restorative effects. Herein, CM‐chitosan‐based NGC is designed to induce the reconstruction of damaged peripheral nerves without addition of other activation factors. CM‐chitosan possesses excellent performance in vitro for nerve tissue engineering, such as increasing the organization of filamentous actin and the expression of phospho‐Akt, and facilitating the cell cycle and migration of Schwann cells. Moreover, CM‐chitosan exhibits increased longevity upon cross‐linking (C‐CM‐chitosan) with 1, 4‐Butanediol diglycidyl ether, and C‐CM‐chitosan fibers possess appropriate biocompatibility. In order to imitate the structure of peripheral nerves, multichannel bioactive NGCs are prepared from lumen fillers of oriented C‐CM‐chitosan fibers and outer warp‐knitted chitosan pipeline. Implantation of the C‐CM‐chitosan NGCs to rats with 10‐mm defects of peripheral nerves effectively improve nerve function reconstruction by increasing the sciatic functional index, decreasing the latent periods of heat tingling, enhancing the gastrocnemius muscle, and promoting nerve axon recovery, showing regenerative efficacy similar to that of autograft. The results lay a theoretical foundation for improving the potential high‐value applications of CM‐chitosan‐based bioactive materials in nerve tissue engineering.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Facilitation of Cell Cycle and Cellular Migration of Rat Schwann Cells by O‐Carboxymethyl Chitosan to Support Peripheral Nerve Regeneration

Jiang

Zhang

Liu

et al. 2023

Macromolecular Bioscience

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show abstract

“…Other natural materials, including native fibrin ( Du et al, 2017 ; Wang et al, 2018 ; Razavi et al, 2021 ), collagen ( Saeki et al, 2018 ; Yao et al, 2018 ; He et al, 2021 ; Wang et al, 2021 ; Zheng et al, 2021 ), keratin ( Apel et al, 2008 ; Lin et al, 2012 ; Pace et al, 2014 ), alginate ( Lin et al, 2017 ; Rahmati et al, 2021 ; Abdelbasset et al, 2022 ), chitin ( Bak et al, 2017 ; Lu C. F. et al, 2021 ; Yang et al, 2022b ), chitosan ( Li et al, 2018 ; Vishnoi et al, 2019 ), and silk fibroin ( Carvalho et al, 2021 ; Kim et al, 2021 ; Zhao et al, 2020), as well as extracellular matrix (ECM) ( Li T. et al, 2021 ; Kong et al, 2021 ; Kong et al, 2022 ), have shown great potential in treating long gap nerve defects. For instance, Wang et al prepared a nerve catheter using chitosan/chitin to achieve excellent angiogenesis in nerve regeneration process for successfully repairing the 10 mm sciatic nerve defect in rats ( Wang et al, 2016 ).…”

Section: Research Progress Of Peripheral Nerve Graftsmentioning

confidence: 99%

The success of biomaterial-based tissue engineering strategies for peripheral nerve regeneration

Jiang

Tang²,

Li³

et al. 2022

Front. Bioeng. Biotechnol.

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Peripheral nerve injury is a clinically common injury that causes sensory dysfunction and locomotor system degeneration, which seriously affects the quality of the patients’ daily life. Long gapped defects in large nerve are difficult to repair via surgery and limited donor source of autologous nerve greatly challenges the successful nerve repair by transplantation. Significantly, remarkable progress has been made in repairing the peripheral nerve injury using artificial nerve grafts and a variety of products for peripheral nerve repair have emerged been approved globally in recent years. The raw materials of these commercial products includes natural/synthetic polymers, extracellular matrix. Despite a lot of effort, the desirable functional recovery still remains great challenges in long gapped nerve defects. Thus this review discusses the recent development of tissue engineering products for peripheral nerve repair and the design of bionic grafts improving the local microenvironment for accelerating nerve regeneration against locomotor disorder, which may provide potential strategies for the repair of long gaps or thick nerve defects by multifunctional biomaterials.

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“…Electrospun nanofibers have high specific surface area, diverse structures, wide sources of preparation materials, unique physicochemical properties, and flexibility in surface modification [ 15 , 16 ]. In addition, electrospun nanofibers can mimic the structure of the extracellular matrix (ECM), which can promote cell adhesion, proliferation, differentiation, and guide tissue repair and regeneration [ 17 , 18 ]. These unique properties appealed to researchers to endow electrospun nanofibers with the ability to respond to stimuli.…”

Section: Introductionmentioning

confidence: 99%

Stimuli-responsive electrospun nanofibers for drug delivery, cancer therapy, wound dressing, and tissue engineering

Chen¹,

Li²,

Li³

et al. 2023

J Nanobiotechnol

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The stimuli-responsive nanofibers prepared by electrospinning have become an ideal stimuli-responsive material due to their large specific surface area and porosity, which can respond extremely quickly to external environmental incitement. As an intelligent drug delivery platform, stimuli-responsive nanofibers can efficiently load drugs and then be stimulated by specific conditions (light, temperature, magnetic field, ultrasound, pH or ROS, etc.) to achieve slow, on-demand or targeted release, showing great potential in areas such as drug delivery, tumor therapy, wound dressing, and tissue engineering. Therefore, this paper reviews the recent trends of stimuli-responsive electrospun nanofibers as intelligent drug delivery platforms in the field of biomedicine.

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Electrospinning porcine decellularized nerve matrix scaffold for peripheral nerve regeneration

Cited by 16 publications

References 43 publications

Facilitation of Cell Cycle and Cellular Migration of Rat Schwann Cells by O‐Carboxymethyl Chitosan to Support Peripheral Nerve Regeneration

Facilitation of Cell Cycle and Cellular Migration of Rat Schwann Cells by O‐Carboxymethyl Chitosan to Support Peripheral Nerve Regeneration

The success of biomaterial-based tissue engineering strategies for peripheral nerve regeneration

Stimuli-responsive electrospun nanofibers for drug delivery, cancer therapy, wound dressing, and tissue engineering

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