Electrospinning of novel biodegradable poly(ester urethane)s and poly(ester urethane urea)s for soft tissue-engineering applications

Caracciolo, Pablo C.; Thomas, Vinoy; Vohra, Yogesh K.; Buffa, Fabián Alejandro; Abraham, Gustavo Abel

doi:10.1007/s10856-009-3768-3

Cited by 52 publications

(45 citation statements)

References 45 publications

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“…Varieties of polymer could be used in electrospinning, such as polyurethane [33,34], nylon [35,36], polyvinyl alcohol [37], cellulose acetate [28], poly(caprolactone) [15,[38][39][40][41], polyesterurethane [14,[42][43][44][45][46], poly(L-lactic acid) [16,24,[47][48][49][50] and so on. The selection of polymer is generally determined according to the practical application.…”

Section: Solventmentioning

confidence: 99%

“…The porous structure of electrospun nanofibers strongly resembles that of ECM in tissue and nanofibers prepared from biocompatible polymeric materials, such as poly(caprolactone) [15,[38][39][40][41], polyesterurethane [14,[42][43][44][45][46], poly(L-lactic acid) [16,24,[47][48][49][50] and polyethylene terephthalate [18], provide a satisfactory microenvironment for cell culture (Figure 6d). The results of X-ray images of repaired tendons of mice at 8 weeks posttransplantation also indicate that randomly-oriented topographic scaffolds have significantly higher potential to induce ectopic bone formation when compared to aligned scaffolds.…”

Section: Applications Of Electrospun Nanofibersmentioning

confidence: 99%

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Functional Nanofibers with Multiscale Structure by Electrospinning

et al. 2018

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diameters, compositions and orientations. In addition, the flexibility of electrospinning allows for controlling the structure (e.g. hollow fibers) and arrangement (e.g. well-ordered fiber arrays) of the fibers so that nanofibers of desired properties can be fabricated depending on the intended applications.The diameters of electrospun fibers can be easily varied from tens of nanometers to microns, and thus the fibers possess extremely high surface-to-volume ratio, making them suitable for activities requiring a high degree of physical contact, such as providing sites for chemical reactions. Membranes consisted of electrospun fibers possess relatively uniform pore size distribution and significantly high porosity and thus are good filter to capture small-sized particulates by physical entrapment [22,23,[27][28][29]. In addition, the nanofibers fabricated by electrospinning possess a relatively defect-free structure at the molecular scale, showing enhanced mechanical properties. Because of these advantages, electrospun fibers have been widely used in various applications. For example, in biomedical applications, by using biocompatible materials, electrospun fibrous scaffold have been considered as suitable substrates for tissue engineering [13][14][15][16] and artificial blood vessels [18], and also used to study the differentiation of stem cell [24]. While in the field of electromechanics, various sensors, such as tactile sensors [8,9], chemical sensors [3,5,6,10,11,17,19] and optical sensors [12], are using electrospun fibers as substrates or sensing elements.In this review, we provide an overview of electrospinning technologies, which have been developed to prepare nanofibers of different materials, ranging from inorganic ceramics to organic polymers, and systematically summarize the techniques to adjust the system parameters and thus tailor the properties of the fibers, including the fiber diameter and its surface morphology. We also highlight the advance of electrospinning techniques in creating complex structures with desired properties, such as well-aligned fiber arrays and specifically patterned fiber structure on the collector. Construction of nanofibers with more complex internal structure, such as corehttps://doi.org/10.1515/nanofab-2018-0002Received December 21, 2017; accepted March 19, 2018 Abstract: Electrospinning can produce nanofibers with extremely high surface-to-volume ratio and well tunable properties. The technique has been widely used in different disciplines. To fabricate fibers with required properties, parameters of fabrication should be well controlled and adjusted according to specific applications. Modification of electrospinning devices to align fibers in highly ordered architectures could improve their functions. Enhanced efficiency have also been obtained through the upscaling modification of spinnerets. With the outstanding efficiency, electrospinning has exhibited huge potentials to construct various nanostructures, such as artificial vessel, membrane for desalination and so on.

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Section: Solventmentioning

confidence: 99%

Section: Applications Of Electrospun Nanofibersmentioning

confidence: 99%

Functional Nanofibers with Multiscale Structure by Electrospinning

et al. 2018

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“…In this respect, the range of mechanical and morphological properties that can be obtained with PUR is significantly larger than with commonly used medical grade biodegradable polymers for example: PLA, PGA, poly(DL-lactide) (PDLLA) [39][40][41][42]. Many applications of segmented PUR in TE field, such as cardiovascular TE [34,43,44] musculoskeletal applications (anterior cruciate ligament) [42], knee joint meniscus [45], bone TE [46], smooth muscle cell constructs for contractile muscle [47,48], and nerve regeneration [49][50][51], have been recently evaluated. For polyurethanes containing aromatic isocyanate moieties like methane-4,4'-diphenyldiisocyanate (MDI) and 2,4-toluenediisocyanate (TDI) toxic aromatic diamines were indicated after degradation.…”

Section: Polyurethanes In Tementioning

confidence: 99%

“…Fibres with a variety of cross sectional shapes and sizes may be produced from different polymers. Electrospun fibres, from polymer solutions and melts, can be obtained in the average diameter range of few nanometers to several micrometres (usually between 50 nm and 5 μm) [11,12]. The weakness of this technique is the difficulty to preserve suitable pore sizes for cellular ingrowth caused by inadequate reproduction of extracellular matrix (ECM), poor reproducibility of the scaffolds and preservation of their restricted architecture [5].…”

Section: Introductionmentioning

confidence: 99%

Ascorbic Acid in Polyurethane Systems for Tissue Engineering

Kucińska-Lipka¹,

St.²,

Janik³

et al. 2016

ChChT

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Abstract. The introduction of the paper was devoted to the main items of Tissue Engineering (TE) and the way of porous structure obtaining as scaffolds. Furthermore, the significant role of the scaffold design in TE was described. It was shown, that properly designed polyurethanes (PURs) find application in TE due to the proper physicochemical, mechanical and biological properties. Then the use of L-ascorbic acid (L-AA) in PUR systems for TE was described. L-AA has been applied in this area due to its suitable biological characteristics and antioxidative properties. Moreover, L-AA influences tissue regeneration due to improving collagen synthesis, which is a primary component of the extracellular matrix (ECM). Modification of PUR with L-AA leads to the materials with higher biocompatibility and such system is promising for TE applications.

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“…Otros investigadores también reportaron la síntesis de PUs biorreabsorbibles usando extensores de cadena novedosos [121][122][123]. A pesar de su rol central, la síntesis de PUs asistida por esta tecnología ha sido estudiada de forma muy limitada y la mayoría de los estudios se centraron principalmente en los aspectos químicos de la vía de síntesis y las características moleculares obtenidas.…”

Section: Poliuretanosunclassified

Aplicaciones de la tecnología de radiación de microondas en la síntesis de biomateriales

Sosnik¹,

Gotelli²

Biomateriais Aplicados Ao Desenvolvimento De Sistemas Terapêuticos Avançados

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A navegação consulta e descarregamento dos títulos inseridos nas Bibliotecas Digitais UC Digitalis, UC Pombalina e UC Impactum, pressupõem a aceitação plena e sem reservas dos Termos e Condições de Uso destas Bibliotecas Digitais, disponíveis em https://digitalis.uc.pt/pt-pt/termos.Conforme exposto nos referidos Termos e Condições de Uso, o descarregamento de títulos de acesso restrito requer uma licença válida de autorização devendo o utilizador aceder ao(s) documento(s) a partir de um endereço de IP da instituição detentora da supramencionada licença.Ao utilizador é apenas permitido o descarregamento para uso pessoal, pelo que o emprego do(s) título(s) descarregado(s) para outro fim, designadamente comercial, carece de autorização do respetivo autor ou editor da obra. Na medida em que todas as obras da UC Digitalis se encontram protegidas pelo Código do Direito de Autor e Direitos Conexos e demais legislação aplicável, toda a cópia, parcial ou total, deste documento, nos casos em que é legalmente admitida, deverá conter ou fazer-se acompanhar por este aviso.Aplicaciones de la tecnología de radiación de microondas en la síntesis de biomateriales. Autor(es):Sosnik, Alejandro; Gotelli, Gustavo Resumen:El escalado industrial de la producción de biomateriales poliméricos sintéticos y semi-sintéticos enfrenta desafíos relevantes como la limitada reproducibilidad y difícil estandarización de los procesos sintéticos. más recientemente, a su implementación en la síntesis de polímeros y materiales cerámicos para aplicaciones terapéuticas. El presente capí-tulo presenta el Estado-del-Arte de las aplicaciones más destacadas de esta tecnología en la síntesis de biomateriales poliméricos orgánicos e inorgánicos y discute el potencial de la misma para optimizar la transferencia a la clínica de nuevos biomateriales.Palabras clave: Síntesis de biomateriales poliméricos asistida por radiación de microondas; polimerización de apertura de anillo;polimerización de injerto molecular; hidrogeles; micropartículas y nanopartículas; materiales compuestos. Abstract:The industrial scale-up of the production of synthetic and semisynthetic polymeric biomaterials faces challenges due to the limited reproducibility and difficult standardization of the synthetic methods.The scale-up demands the adjustment of the process variables, a phase that is crucial and that is associated with the growth of the produc- This chapter presents a State-of-the-Art of the most relevant applications of microwave radiation for the synthesis of organic and inorganic polymeric biomaterials and discusses its potential to optimize the bench-to-bedside translation of new biomaterials.

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Electrospinning of novel biodegradable poly(ester urethane)s and poly(ester urethane urea)s for soft tissue-engineering applications

Cited by 52 publications

References 45 publications

Functional Nanofibers with Multiscale Structure by Electrospinning

Functional Nanofibers with Multiscale Structure by Electrospinning

Ascorbic Acid in Polyurethane Systems for Tissue Engineering

Aplicaciones de la tecnología de radiación de microondas en la síntesis de biomateriales

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