Electrospinning of l-tyrosine polyurethanes for potential biomedical applications

Shah, Parth; Manthe, Rachel L.; Lopina, Stephanie T.; Yun, Yang

doi:10.1016/j.polymer.2009.02.048

Cited by 52 publications

(27 citation statements)

References 36 publications

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“…Much like the electrospun scaffolds, the blend films containing a higher percentage of PEG 1000 -HDI-DTH degraded to a greater extent than their high PCL 1250 -HDI-DTH counterparts. This trend is consistent with the previous literature results [14,16] and persists through all blend comparisons. The final values of mass loss for thin films after 35 days were 16.6 ± 1.0% ISRN Nanotechnology It should be noted that, despite following the same pattern of PEG 1000 -HDI-DTH allowing for greater degradation, the electrospun scaffolds lost much more mass (as a percentage) than thin films over the same period of time.…”

Section: Hydrolytic Degradationsupporting

confidence: 93%

“…The two polyurethanes, PEG 1000 -HDI-DTH and PCL 1250 -HDI-DTH, were synthesized using a procedure similar to those reported in literature [13][14][15][16]. The synthesis primarily involves two steps: (1) synthesis of the chain extender DTH by a carbodiimidemediated condensation reaction [13] and (2) synthesis of the polyurethane by condensation polymerization with PEG or PCL as the macrodiol, HDI as the diisocyanate, and DTH as the chain extender.…”

Section: Synthesis Of the Polyurethanesmentioning

confidence: 99%

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Fabrication and Degradation of Electrospun Scaffolds from L-Tyrosine-Based Polyurethane Blends for Tissue Engineering Applications

Spagnuolo

Liu

2012

ISRN Nanotechnology

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It is important to control the degradation rate of a tissue-engineered scaffold so that the scaffold will degrade in an appropriate matching rate as the tissue cells grow in. A set of potential tissue engineering scaffolds with controllable rates of degradation were fabricated from blends of two biocompatible, biodegradable L-tyrosine-based polyurethanes (PEG 1000 -HDI-DTH and PCL 1250 -HDI-DTH) using the electrospinning process. The scaffolds were characterized by mat morphology, fiber diameter, diameter distribution, pore size, and hydrolytic degradation behavior. The majority of the scaffolds, despite having radically different chemical compositions, possessed no statistical difference with pore sizes and fiber diameters. The degradation pattern observed indicated that scaffolds consisting of a greater mass percentage of PEG 1000 -HDI-DTH decayed to a greater extent than those containing higher concentrations of PCL 1250 -HDI-DTH. The degradation rates of the electrospun scaffolds were much higher than those of the thin cast films with same compositions. These patterns were consistent through all blends. The work demonstrates one practical method of controlling the degradation of biopolymer scaffolds without significantly affecting an intended morphology.

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Section: Hydrolytic Degradationsupporting

confidence: 93%

Section: Synthesis Of the Polyurethanesmentioning

confidence: 99%

Fabrication and Degradation of Electrospun Scaffolds from L-Tyrosine-Based Polyurethane Blends for Tissue Engineering Applications

Spagnuolo

Liu

2012

ISRN Nanotechnology

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“…Base polyurethanes have been well demonstrated to be biocompatible and stable in vivo and therefore have been used in biomedical devices such as insulators for cardiac pacing leads, ventricular assist devices, vascular prostheses, drug delivery implants, tissue adhesives, skin wound dressings, etc [11–14]. For example, Sureskin ® II Silver is an FDA approved wound dressing consisting of polyurethane foam that delivers silver-containing agents for treating dermal ulcers, post-operative wounds, superficial wounds, and abrasions [15].…”

Section: Release Kinetics From Non-degradable Polymeric Matricesmentioning

confidence: 99%

Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems

Kao

2010

Expert Opinion on Drug Delivery

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602

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Importance of the field-The advancement in material design and engineering has led to the rapid development of novel materials with increasing complexity and functions. Both non-degradable and degradable polymers have found wide applications in the controlled delivery field. Studies on drug release kinetics provide important information into the function of material systems. To elucidate the detailed transport mechanism and the structure-function relationship of a material system, it is critical to bridge the gap between the macroscopic data and the transport behavior at the molecular level.Areas covered in this review-The structure and function information of selected nondegradable and degradable polymers have been collected and summarized from literatures published after 1990s. The release kinetics of selected drug compounds from various material systems will be discussed in case studies. Recent progresses in the mathematical models based on different transport mechanisms will be highlighted.What the reader will gain-This article aims to provide an overview of structure-function relationships of selected non-degradable and degradable polymers as drug delivery matrices.Take home message-Understanding the structure-function relationship of the material system is key to the successful design of a delivery system for a particular application. Moreover, developing complex polymeric matrices requires more robust mathematical models to elucidate the solute transport mechanisms.

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“…Em alguns casos, a microscopia eletrônica de transmissão (MET) também foi utilizada; o equipamento foi um microscópio Phillips ® , Suportes poliméricos para produção de tecidos do corpo humano devem ter uma série de pré-requisitos [8] como porosidade elevada, uma química superficial que permita a adesão, crescimento e diferenciação das células e uma taxa de degradação similar à taxa de regeneração do tecido. Adicionalmente devem ter a mesma estrutura ou topologia da matriz extracelular.…”

Section: Caracterização Morfológica Das Mantas Nanofibrilicasunclassified

Viabilidade celular de nanofibras de polímeros biodegradáveis e seus nanocompósitos com argila montmorilonita

Góes¹,

Carvalho²,

Oréfice³

et al. 2012

Polímeros

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Resumo: Mantas não tecidas de nanofibras de três polímeros biodegradáveis poli(ácido láctico), PDLLA, poli(ε-caprolactona), PCL, e poli(butileno adipato-co-tereftalato), PBAT e seus nanocompósitos com uma nanoargila montmorilonita (MMT) foram produzidas por eletrofiação. A morfologia, o comportamento térmico e a estrutura interna das nanofibras foram analisados por microscopia eletrônica de varredura e transmissão, calorimetria diferencial de varredura e difração de raios X, respectivamente. Observou-se que as nanofibras dos nanocompósitos possuíam diâmetros menores do que os correspondentes polímeros puros e que as nanofibras de PBAT puro e de PBAT/MMT apresentavam a menor cristalinidade de todas as mantas. A viabilidade celular de todas as nanofibras foi analisada pela técnica de redução do sal de tetrazolium pelo complexo enzimático piruvato desidrogenase presente na matriz de mitocôndrias (teste MTT). Os resultados mostraram que nenhuma manta nanofibrílica apresentou toxicidade às células e que as nanofibras de PBAT puro e seu nanocompósito propiciaram ainda um ambiente mais favorável ao desenvolvimento celular de fibroblastos de cardiomiócitos do que as condições oferecidas pelo controles, provavelmente por apresentarem menores diâmetros e baixa cristalinidade em relação às demais nanofibras. Estes resultados mostram o potencial de uso destas mantas nanofibrílicas como suportes de crescimento celular. Palavras-chave: Viabilidade celular, nanofibras, eletrofiação, nanocompósitos, polímeros biodegradáveis. Cell Viability of Nanofibers from Biodegradable Polymers and their Nanocomposites with MontmorilloniteAbstract: Non-woven mats of nanofibers of three biodegradable polymers, viz. poly(lactic acid), PDLLA, poly(ε-caprolactone), PCL, and poly(butylene adipate-co-terephthalate), PBAT, and their nanocomposites with montmorillonite nanoclay (MMT) were produced by electrospinning. The morphology, thermal behavior and internal structure of the nanofibers were analyzed by scanning and transmission electron microscopy, differential scanning calorimetry and wide angle X-ray diffraction, respectively. The nanofibers of the nanocomposites had lower diameters than the nanofibers of the corresponding neat polymers, while the nanofibers from PBAT and PBAT/MMT were the least crystalline. The cell viability of all the nanofibers was analyzed by reduction of the tetrazolium salt by the pyruvate dehydrogenase enzymatic complex present in the mitochondria (MTT test). None of the nanofibers was toxic to the cells and the PBAT and PBAT/MMT nanofibers exhibited a more favorable environment for developing fibroblasts from cardiomyocytes than the control, probably due to their low crystallinity. These results demonstrated the potential use of nanofibers´ mats as scaffolds for cell growth. Keywords: Cell viability, nanofibers, electrospinning, nanocomposites, biodegradable polymers. IntroduçãoNanofibras de polímeros podem ser facilmente produzidas pelo processo de eletrofiação, desde que os polímeros tenham uma boa solubilidade em s...

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Electrospinning of l-tyrosine polyurethanes for potential biomedical applications

Cited by 52 publications

References 36 publications

Fabrication and Degradation of Electrospun Scaffolds from L-Tyrosine-Based Polyurethane Blends for Tissue Engineering Applications

Fabrication and Degradation of Electrospun Scaffolds from L-Tyrosine-Based Polyurethane Blends for Tissue Engineering Applications

Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems

Viabilidade celular de nanofibras de polímeros biodegradáveis e seus nanocompósitos com argila montmorilonita

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