Electrospinning for regenerative medicine: a review of the main topics

Braghirolli, Daikelly Iglesias; Steffens, Daniela; Pranke, Patrícia

doi:10.1016/j.drudis.2014.03.024

Cited by 228 publications

(152 citation statements)

References 128 publications

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“…With respect to fabrication methods, electro-spinning (Figure 4) appears to be the method of choice, as aligned nano-to micro-fibrous scaffolds can be produced with mechanical and structural features similar to the tissue to be replaced and with ability to control permanently differentiated and stem cell fate in vitro; to locally deliver in a controlled manner pharmacological agents, biological molecules and cells at the side of injury; and to enhance directional neotissue formation [404][405][406][407][408][409]. Although electro-spun collagen scaffolds have demonstrated improved neotissue alignment and mechanical properties, over control counterparts in a rabbit Achilles tendon model [410] the realisation that the use of fluoro-alcohols denatures the triple helical confirmation of collagen [411,412] has reduced further investigations.…”

Section: Bottom-up Approached For Tendon Repair Based On Synthetic Inmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

172

188

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Section: Bottom-up Approached For Tendon Repair Based On Synthetic Inmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

172

188

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“…These nanofiber webs can have several applications, including medical [1][2][3], pharmaceutical [4,5], sensor [6], filtering [7][8][9], clothing, construction engineering applications as well as composites [10,11]. Nanofibers have unique properties such as high surface to mass ratio and flexibility that makes possible to use them as reinforcement of composites.…”

Section: Introductionmentioning

confidence: 99%

Compressibility of carbon fabrics with needleless electrospun PAN nanofibrous interleaves

Lomov

Molnár²

2016

Express Polym. Lett.

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Abstract. The present paper investigates how the presence of nanofiber interleaves affects the compressibility of the layup during manufacturing of the composites and hence determining the theoretically attainable fiber volume fraction at the given processing pressure. The results show that up to the interleave areal density of 10 g/m 2 per nanofiber layer the decrease of fiber volume fraction does not exceed 3% for a laminate of carbon fiber woven fabric. Interleaves inside a fabric laminate are more compressible than a plain electrospun veil. It can be explained as the nanofibers penetrate between the carbon fibers when applying compression during composite manufacturing. It can be stated that there is a strong interference between the interleaves and the carbon reinforcement, which can lead to effective toughness improvement of the composite without significant alteration of fiber volume content.

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“…There are several different methods of producing fiber-based scaffolds, such as electrospinning, meltspinning, wetspinning, biospinning and microfluidic spinning 5,6 . The wetspinning method was chosen for this study.…”

Section: Introductionmentioning

confidence: 99%

Fibers Obtained from Alginate, Chitosan and Hybrid Used in the Development of Scaffolds

et al. 2017

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The main aim of this study was to develop scaffolds based on alginate, chitosan and hybrid fibers with and without glycerol. The scaffolds developed underwent assessments for tensile property, swelling ratio and weight loss, cellular viability, degradation and biomineralization, as well as DSC/TGA thermal analysis. Tenacity values showed that use of glycerol and the interaction between alginate and chitosan as a hybrid fiber were associated with increasing tenacity values. In the swelling and weight loss study, the scaffolds containing glycerol presented lower weight loss and higher water absorption values in all scaffolds, compared to scaffolds without glycerol, indicating that glycerol acted as a stabilizer. None of the alginate, chitosan and hybrid scaffolds, with or without glycerol, decreased cell viability. On the third day of the biomineralization assay, chitosan without glycerol indicated the presence of apatite crystals. The degradation study showed that glycerol may have acted as a stabilizer.

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Electrospinning for regenerative medicine: a review of the main topics

Cited by 228 publications

References 128 publications

The past, present and future in scaffold-based tendon treatments

The past, present and future in scaffold-based tendon treatments

Compressibility of carbon fabrics with needleless electrospun PAN nanofibrous interleaves

Fibers Obtained from Alginate, Chitosan and Hybrid Used in the Development of Scaffolds

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