Electrospinning and crosslinking of polyvinyl alcohol/chitosan composite nanofiber for transdermal drug delivery

Cui, Zhixiang; Zheng, Zifeng; Lin, Luyin; Si, Junhui; Wang, Qianting; Peng, Xiangfang; Chen, Wenzhe

doi:10.1002/adv.21850

Cited by 165 publications

(79 citation statements)

References 43 publications

(91 reference statements)

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“…The higher the silica content is, the shorter the span. The addition of silica consequently reduced the volume fraction of PEG and hence the number of its crosslinks . In general, Figure shows that both E ′ and G ′ values increase with silica content.…”

Section: Resultsmentioning

confidence: 89%

Dynamic tensile and shear storage moduli of PEG/silica‐polymorph composites

Fauziyah

Hilmi

Fadly

et al. 2018

J of Applied Polymer Sci

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The effect of silica polymorphs on the thermomechanical properties of 0, 5, 10, and 20 wt % silica particles-reinforced-based poly(ethylene glycol) (PEG) composites have been studied as a function of temperature using dynamic mechanical analysis (DMA). The silica polymorphs exhibited quartz (Q), cristobalite (C), and amorphous (A) phases, which were obtained by processing natural silica sand. The DMA thermomechanical properties were determined in tensile (E) and shear (G) modes. The maximum storage moduli (E 0 and G 0 ) were achieved by samples with 20 wt % silica for all type of fillers. These values increased approximately 12 times for PEG/Q, 10 times for PEG/A, and 11 times for PEG/C composites compared to the pure PEG. Furthermore, the Poisson's ratio values of the composites were filler phase dependent, that is, 0.39-0.47 for PEG/Q, 0.15-0.18 for PEG/A, and somewhat anomalous for PEG/C composites.

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Section: Resultsmentioning

confidence: 89%

Dynamic tensile and shear storage moduli of PEG/silica‐polymorph composites

Fauziyah

Hilmi

Fadly

et al. 2018

J of Applied Polymer Sci

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“…It has been widely applied for NFs preparation, either alone or blended with natural polymer (such as CS), as topical and transdermal scaffolds. 4,5 Phytochemicals are naturally occurring compounds found in plants that have versatile pharmacological activities against a variety of diseases. 6 Amongst natural phenolic compounds that need to be incorporated in promising delivery systems is clove essential oil (CEO).…”

Section: Introductionmentioning

confidence: 99%

<p>Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation</p>

Aman¹,

Hashim²,

Meshali³

2020

IJN

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Purpose: Clove essential oil is a phytochemical possessing a vast array of biological activities. Nevertheless, fabricating nano topical delivery systems targeted to augment the anti-inflammatory activity of the oil has not been investigated so far. Accordingly, in this study, controlled release nanoparticulate systems, namely nanoemulgel and nanofibers (NFs), of the oil were developed to achieve such goal. Methods: The nanoemulsion was incorporated in the hydrogel matrix of mixed biopolymerschitosan, guar gum and gum acaciato formulate nanoemulsion-based nanoemulgel. Taguchi's model was adopted to evaluate the effect of independently controlled parameters, namely, the concentration of chitosan (X 1), guar gum (X 2), and gum acacia (X 3) on different dependently measured parameters. Additionally, the nanoemulsion-based NFs were prepared by the electrospinning technique using polyvinyl alcohol (PVA) polymer. Extensive in vitro, ex vivo and in vivo evaluations of the aforementioned formulae were conducted. Results: Both Fourier transform-infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) established the complete dispersion of the nanoemulsion in the polymeric matrices of the prepared nanoemulgel and NFs. The ex vivo skin permeation data of clove essential oil from the prepared formulations showed that NFs can sustain its penetration through the skin comparably with nanoemulgel. Topical treatment with NFs (once application) and nanoemulgel (twice application) evoked a marvelous in vivo anti-inflammatory activity against croton oil-induced mouse skin inflammation model when compared with pure clove essential oil along with relatively higher efficacy of medicated NFs than that of medicated nanoemulgel. Such prominent anti-inflammatory activity was affirmed by histopathological and immunohistochemical examinations. Conclusion: These results indicated that nanoemulsion-based nanoemulgel and nanoemulsion-based NFs could be introduced to the phytomedicine field as promising topical delivery systems for effective treatment of inflammatory diseases instead of nonsteroidal antiinflammatory drugs that possess adverse effects.

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“…Wybór polimerowego nośnika leku do elektroprzę dzenia jest podyktowany przede wszystkim planowa nym sposobem uwalniania substancji czynnej [33][34][35][36]. W zależności od zastosowanego polimeru mechanizm uwalniania substancji aktywnej może się odbywać m.in.…”

Section: Systemy Uwalniania Lekówunclassified

Electrospun polymer nanofibers for medical applications

Winkler¹,

Maliszewska²,

Czapka³

2020

Polimery

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Streszczenie: Nanowłókna polimerowe wzbudzają obecnie ogromne zainteresowanie ze względu na ich potencjalne wykorzystanie w różnych procesach technologicznych, np. w produkcji tkanin lub wy twarzaniu membran. Włókna te wykazują wyjątkowe właściwości, takie jak: duży stosunek powierzch ni do objętości oraz duża porowatość. Znanych jest kilka metod wytwarzania nanowłókien, jednak ze względu na prostotę, powtarzalność i niewielkie koszty, najpowszechniej stosowane jest przędzenie elektrostatyczne. Przedstawiono przegląd najnowszych osiągnięć w zakresie zastosowań nanowłókien polimerowych w medycynie, obejmujący zagadnienia materiałów opatrunkowych, uwalniania sub stancji aktywnych oraz inżynierii tkankowej.Słowa kluczowe: elektroprzędzenie, nanowłókna, zastosowania medyczne.Abstract: Polymer nanofibers are currently of great interest in terms of their potential use in various technological processes, e.g. in the manufacture of textiles or membranes. These fibers are characterized by extraordinary properties such as high surface to volume ratio and high porosity. There are several methods of manufacturing nanofibers, but for reasons of simplicity, repeatability and low cost, elec trostatic spinning is the most common. The article presents a review of the latest developments in the application of polymer nanofibers in medicine, including such issues as bandage materials, release of active substances and tissue engineering.

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Electrospinning and crosslinking of polyvinyl alcohol/chitosan composite nanofiber for transdermal drug delivery

Cited by 165 publications

References 43 publications

Dynamic tensile and shear storage moduli of PEG/silica‐polymorph composites

Dynamic tensile and shear storage moduli of PEG/silica‐polymorph composites

<p>Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation</p>

Electrospun polymer nanofibers for medical applications

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