Electroretinographic oscillatory potentials in diabetic retinopathy

Li, Xiaoxin; Sun, Xiaoqi; Hu, Yutong; Huang, Jie; Zhang, Huirong

doi:10.1007/bf00156006

Cited by 25 publications

(17 citation statements)

References 14 publications

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“…In agreement with findings in people with diabetes, STZ‐diabetic rats show delayed oscillatory potential implicit time (at 12 weeks control; 28 ± 0.5 versus STZ; 33 ± 0.9 ms) 80,91 and reduced (at 12 weeks control; 107 ± 7 versus STZ; 76 ± 7 mV) oscillatory potential amplitude, 80,100,101 as shown in Figure 6. Layton, Safa and Osborne 102 and Bui and coauthors 74 reported a reduction in both oscillatory potential and b‐wave amplitudes (Figure 3A), which implies that the changes in oscillatory potential may reflect losses of ON‐bipolar cell b‐wave response.…”

Section: Laboratory Evidence Linking Diabetes and Glaucomasupporting

confidence: 90%

Clinical and experimental links between diabetes and glaucoma

Wong

Bui²,

Vingrys³

2011

Clinical and Experimental Optometry

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Glaucoma is a leading cause of blindness. It is a multifactorial condition, the risk factors for which are increasingly well defined from large-scale epidemiological studies. One risk factor that remains controversial is the presence of diabetes. It has been proposed that diabetic eyes are at greater risk of injury from external stressors, such as elevated intraocular pressure. Alternatively, diabetes may cause ganglion cell loss, which becomes additive to a glaucomatous ganglion cell injury. Several clinical trials have considered whether a link exists between diabetes and glaucoma. In this review, we outline these studies and consider the causes for their lack of concordant findings. We also review the biochemical and cellular similarities between the two conditions. Moreover, we review the available literature that attempts to answer the question of whether the presence of diabetes increases the risk of developing glaucoma. At present, laboratory studies provide robust evidence for an association between diabetes and glaucoma. Key words: diabetes, dyslipidaemia, ganglion cells, glaucoma, hyperglycaemia, intraocular pressure, retina Diabetes is a leading health priority, as it can cause severe systemic complications, such as retinopathy, neuropathy and nephropathy. This metabolic disorder results from either altered secretion of insulin by the pancreas (type 1 diabetes) or insulin resistance at a cellular level (type 2 diabetes). These changes produce widespread abnormalities in glucose uptake, resulting in hyperglycaemia, as well as abnormal metabolism and formation of lipids (Figure 1), which impact on neurons, blood vessels and glial cells. Indeed, this journal carries an excellent review on glial dysfunction in diabetic eyes.1 Many clinicians will be aware of diabetic retinopathy and its classification, as laid out by the National Health and Medical Research Council Guidelines for the Management of Diabetic Retinopathy. 2 The purpose of this review is not to dwell on the specifics of diabetic retinopathy but to consider whether diabetes predisposes the eye to other disorders, in particular glaucoma.Diabetes has been estimated by the World Health Organization to affect more than 180 million people worldwide. Despite increasing awareness and advances in management of this disease, it is anticipated that the number of sufferers of diabetes will rise to over 360 million by 2030.3 Diabetic eye disease is a leading cause of blindness [4][5][6] in those of working age (aged from 30 to 69 years).7 The Wisconsin Epidemiologic Study of Diabetic Retinopathy reports that both the duration of the disease and its type (1 or 2) affect the chance of expressing retinopathy. 8,9 The prevalence of retinopathy after five years (17 to 29 per cent) increases after 15 years to 78 to 100 per cent.Diabetes is known to increase the risk of other health complications, 10 in particular, cardiovascular problems 11-13 and cerebral ischaemia. 14,15 Of particular interest to eye-care practitioners is the question of whether we should adj...

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Section: Laboratory Evidence Linking Diabetes and Glaucomasupporting

confidence: 90%

Clinical and experimental links between diabetes and glaucoma

Wong

Bui²,

Vingrys³

2011

Clinical and Experimental Optometry

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“…Brown [27] described the relationship of OPs to the retinal circulation. Scotopically induced OPs have been reported to be abnormal in diabetics before any microvascular or autoregulatory abnormalities can be detected [28,29]. The OPs display the earliest signs of disturbances in consequence of an increased intraocular pressure [21,30].…”

Section: Discussionmentioning

confidence: 98%

Hypobaric hypoxia reduces the amplitude of oscillatory potentials in the human ERG

et al. 2007

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“…using the Fourier analysis for measuring the OPs, have observed reduced OP amplitude in persons with early diabetic retinopathy and suggested this assessment as a reliable quantitative method to detect diabetic retinopathy at an early stage45. Li et al 46 have also found reduced OP amplitude recorded in dark and light adaptation, in persons with background retinopathy.…”

Section: Electrophysiological Evaluation Of the Retina: Electroretinomentioning

confidence: 98%

“…Since electrophysiological abnormalities were detected in patients with unsatisfactory glycemic control, an influence of the metabolic control has been suggested31. However these data are not conclusive because other authors have not tested the relationship between FERG, OPs and metabolic control42, 45, 46, 48. In addition, Skrandies and Heinrich have observed that acutely induced hypoglycemia may influence the b‐wave of FERG50.…”

Section: Electrophysiological Evaluation Of the Retina: Electroretinomentioning

confidence: 99%

Visual electrophysiological responses in persons with type 1 diabetes

Parisi

Uccioli

2001

Diabetes Metab. Res. Rev.

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Persons with type 1 diabetes show electrophysiological abnormalities of the visual system which are revealed by methods such as flash electroretinogram (FERG), oscillatory potentials (OPs), pattern electroretinogram (PERG), focal electroretinogram (focal ERG), visual evoked potentials (VEP) in basal condition and after photostress. This review reports the changes in electrophysiological responses of the different structures composing the visual system observed in persons with type 1 diabetes before the development of the overt clinical retinopathy. In persons with type 1 diabetes without retinopathy (IDD), the earlier abnormal electrophysiological responses are recorded from the innermost retinal layers and postretinal visual pathways, as suggested by impaired PERGs and delayed retinocortical time (RCT). These are observed in IDD persons with a disease duration shorter than 6 months. Further electrophysiological changes are recorded from the macula (abnormal focal ERG and VEP after photostress) in IDD persons with disease duration greater than 1 year. Additional electrophysiological changes are recorded from the middle and outer retinal layers (impaired FERG and OPs) in IDD persons with a disease duration greater than 10 years. All the electrophysiological tests show a greater degree of abnormal responses in persons with type 1 diabetes when a background retinopathy is present.

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Electroretinographic oscillatory potentials in diabetic retinopathy

Cited by 25 publications

References 14 publications

Clinical and experimental links between diabetes and glaucoma

Clinical and experimental links between diabetes and glaucoma

Hypobaric hypoxia reduces the amplitude of oscillatory potentials in the human ERG

Visual electrophysiological responses in persons with type 1 diabetes

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