Electrophysiological markers of cognitive deficits in traumatic brain injury: A review

Dockree, Paul M.; Robertson, Ian H.

doi:10.1016/j.ijpsycho.2011.01.004

Cited by 52 publications

(39 citation statements)

References 93 publications

(96 reference statements)

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“…24 Problems with inhibitory control are common in mild to moderate TBI. 25,26 To our knowledge, only one fMRI study has evaluated inhibitory control in blast-related TBI. Matthews and colleagues 27 compared OEF/OIF veterans who had experienced blast-related concussion with either loss of consciousness (LOC) or alteration of consciousness (AOC) using the SST.…”

Section: T Raumatic Brain Injury (Tbi) Is Common In Military Personnementioning

confidence: 99%

Neural Activation during Response Inhibition Differentiates Blast from Mechanical Causes of Mild to Moderate Traumatic Brain Injury

Fischer

Parsons

Durgerian

et al. 2014

Journal of Neurotrauma

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Military personnel involved in Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) commonly experience blastinduced mild to moderate traumatic brain injury (TBI). In this study, we used task-activated functional MRI (fMRI) to determine if blast-related TBI has a differential impact on brain activation in comparison with TBI caused primarily by mechanical forces in civilian settings. Four groups participated: (1) blast-related military TBI (milTBI; n = 21); (2) military controls (milCON; n = 22); (3) non-blast civilian TBI (civTBI; n = 21); and (4) civilian controls (civCON; n = 23) with orthopedic injuries. Mild to moderate TBI (MTBI) occurred 1 to 6 years before enrollment. Participants completed the Stop Signal Task (SST), a measure of inhibitory control, while undergoing fMRI. Brain activation was evaluated with 2 (mil, civ) · 2 (TBI, CON) analyses of variance, corrected for multiple comparisons. During correct inhibitions, fMRI activation was lower in the TBI than CON subjects in regions commonly associated with inhibitory control and the default mode network. In contrast, inhibitory failures showed significant interaction effects in the bilateral inferior temporal, left superior temporal, caudate, and cerebellar regions. Specifically, the milTBI group demonstrated more activation than the milCON group when failing to inhibit; in contrast, the civTBI group exhibited less activation than the civCON group. Covariance analyses controlling for the effects of education and selfreported psychological symptoms did not alter the brain activation findings. These results indicate that the chronic effects of TBI are associated with abnormal brain activation during successful response inhibition. During failed inhibition, the pattern of activation distinguished military from civilian TBI, suggesting that blast-related TBI has a unique effect on brain function that can be distinguished from TBI resulting from mechanical forces associated with sports or motor vehicle accidents. The implications of these findings for diagnosis and treatment of TBI are discussed.

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Section: T Raumatic Brain Injury (Tbi) Is Common In Military Personnementioning

confidence: 99%

Neural Activation during Response Inhibition Differentiates Blast from Mechanical Causes of Mild to Moderate Traumatic Brain Injury

Fischer

Parsons

Durgerian

et al. 2014

Journal of Neurotrauma

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“…However, the neural mechanisms of impaired information processing, a core deficit after many forms of brain injury (Anderson and Arciniegas, 2010;Dockree and Robertson, 2011;Padovani et al, 2012;, are unclear. We propose that gamma oscillations may be an excellent marker of cognitive health and impairment in children.…”

Section: Introductionmentioning

confidence: 99%

Gamma Deficits as a Neural Signature of Cognitive Impairment in Children Treated for Brain Tumors

Dockstader

Wang

Bouffet

et al. 2014

Journal of Neuroscience

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Cognitive impairment is consistently reported in children treated for brain tumors, particularly in the categories of processing speed, memory, and attention. Although tumor site, hydrocephalus, chemotherapy, and cranial radiation therapy (CRT) are all associated with poorer function, CRT predicts the greatest deficits. There is a particularly high correlation between CRT and slowed informationprocessing speed. Cortical gamma-band oscillations have been associated with processing behaviorally relevant information; however, their role in the maintenance of cognition in individuals with processing deficits is unclear. We examined gamma oscillations using magnetoencephalography (MEG) in children undergoing CRT to test whether gamma characteristics can be a signature of cognitive impairment in this population. We collected resting-state data as well as data from baseline and active periods during two visual-motor reaction time tasks of varying cognitive loads from 18 healthy children and 20 patients. We found that only high-gamma oscillations (60 -100 Hz), and not low-gamma oscillations (30 -59 Hz), showed significant group differences in absolute power levels. Overall, compared with healthy children, patients showed the following: (1) lower total high-gamma (60 -100 Hz) power during the resting state, as well as during task-related baseline and performance measures; (2) no change in gamma reactivity to increases in cognitive load; and (3) slower processing speeds both inside and outside MEG. Our findings show that high-gamma oscillations are disrupted in children after treatment for a brain tumor. The temporal dynamic of the high-gamma response during information processing may index cognitive impairment in humans with neurological injury.

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“…Regardless of the explanations for and processes related to altered error processing in TBI-MDD, our results emphasise error awareness as an important therapeutic target for treatments applied to TBI-MDD. Previous research has suggested that error processing following TBI may be treated pharmacologically (Dockree & Robertson, 2011). The results of the current study suggest this is an important avenue for future research in the prevention of MDD post TBI.…”

Section: Discussionmentioning

confidence: 59%

Neural evidence that conscious awareness of errors is reduced in depression following a traumatic brain injury

Bailey

Hoy

Maller

et al. 2015

Biological Psychology

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Electrophysiological markers of cognitive deficits in traumatic brain injury: A review

Cited by 52 publications

References 93 publications

Neural Activation during Response Inhibition Differentiates Blast from Mechanical Causes of Mild to Moderate Traumatic Brain Injury

Neural Activation during Response Inhibition Differentiates Blast from Mechanical Causes of Mild to Moderate Traumatic Brain Injury

Gamma Deficits as a Neural Signature of Cognitive Impairment in Children Treated for Brain Tumors

Neural evidence that conscious awareness of errors is reduced in depression following a traumatic brain injury

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