Neural evidence that conscious awareness of errors is reduced in depression following a traumatic brain injury

Bailey, Neil W.; Hoy, Kate Elizabeth; Maller, Jerome Joseph; Upton, Daniel J.; Segrave, Rebecca; Fitzgibbon, Bernadette M.; Fitzgerald, Paul B.

doi:10.1016/j.biopsycho.2015.01.011

Cited by 9 publications

(7 citation statements)

References 65 publications

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“…Major depression is another condition that can affect the size of the ERN (Ruchsow et al, 2006;Chiu and Deldin, 2007;Holmes and Pizzagalli, 2008), although not always (Schrijvers et al, 2009;Bailey et al, 2015). We saw no relationship between ERN amplitude and the severity of depression symptoms reported on the BDI.…”

Section: Error-related Negativity and Depressionmentioning

confidence: 49%

“…As mentioned previously, one or more sports concussions may reduce the size of the ERN (Pontifex et al, 2009), although others have found no such effect (Larson et al, 2012;Bailey et al, 2015). In comparison to the nature of the impact-related mTBIs described in the sports injury literature, mTBI in the majority of OEF/OIF Veterans is due to blast exposure, which may produce different effects on the brain .…”

Section: Error-related Negativity and Mild Tbimentioning

confidence: 89%

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Intact error monitoring in combat Veterans with post-traumatic stress disorder

Swick

Honzel

Turken

2015

Psychiatry Research: Neuroimaging

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The error-related negativity (ERN) is a neuroelectric signature of performance monitoring during speeded response time tasks. Previous studies indicate that individuals with anxiety disorders show ERN enhancements that correlate with the degree of clinical symptomology. Less is known about the error monitoring system in post-traumatic stress disorder (PTSD). PTSD is characterized by impairments in the regulation of fear and other emotional responses, as well as deficits in maintaining cognitive control. Here, combat Veterans with PTSD were compared to control Veterans in two different versions of the flanker task (n=13 or 14 per group). Replicating and extending previous findings, PTSD patients showed an intact ERN in both experiments. In addition, task performance and error compensation behavior were intact. Finally, ERN amplitude showed no relationship with self-reported PTSD, depression, or post-concussive symptoms. These results suggest that error monitoring represents a relative strength in PTSD that can dissociate from cognitive control functions that are impaired, such as response inhibition and sustained attention. A healthy awareness of errors in external actions could be leveraged to improve interoceptive awareness of emotional state. The results could have positive implications for PTSD treatments that rely on self-monitoring abilities, such as neurofeedback and mindfulness training.

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Section: Error-related Negativity and Depressionmentioning

confidence: 49%

Section: Error-related Negativity and Mild Tbimentioning

confidence: 89%

Intact error monitoring in combat Veterans with post-traumatic stress disorder

Swick

Honzel

Turken

2015

Psychiatry Research: Neuroimaging

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“…No studies with military or sport populations survived to the final article cohort. Two articles did not exclude for pre-TBI depressive disorders, 12,38 three articles did not exclude for co-occurring anxiety disorders, [39][40][41] and two articles excluded for previous TBIs. 39,42 Only one article conducted a formal power analysis 43 and three studies reported effect size statistics.…”

Section: Resultsmentioning

confidence: 99%

“…Two articles did not exclude for pre-TBI depressive disorders, 12,38 three articles did not exclude for co-occurring anxiety disorders, [39][40][41] and two articles excluded for previous TBIs. 39,42 Only one article conducted a formal power analysis 43 and three studies reported effect size statistics. [43][44][45] For details regarding article population, TBI severity, TBI occurrence, timing of imaging post-TBI, and neuroimaging modality, refer to Table 1.…”

Section: Resultsmentioning

confidence: 99%

Neuroimaging correlates of syndromal depression following traumatic brain injury: A systematic review of the literature

Richey

Bryant

Krieg

et al. 2022

Journal of Concussion

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Objective To complete a systematic review of the literature examining neuroimaging findings unique to co-occurring syndromal depression in the setting of TBI. Methods A PRISMA compliant literature search was conducted in PubMed (MEDLINE), PsychINFO, EMBASE, and Scopus databases for articles published prior to April of 2022. The database query yielded 4447 unique articles. These articles were narrowed based on specific inclusion criteria (e.g., clear TBI definition, clear depression construct commenting on the syndrome of major depressive disorder, conducted empirical analyses comparing neuroimaging correlates in TBI subjects with depression versus TBI subjects without depression, controlled for the time interval between TBI occurrence and acquisition of neuroimaging). Results A final cohort of 10 articles resulted, comprising the findings from 423 civilians with brain injury, 129 of which developed post-TBI depression. Four articles studied mild TBI, three mild/moderate, one moderate/severe, and two all-comers, with nine articles focusing on single TBI and one including both single and recurrent injuries. Spatially convergent structural abnormalities in individuals with TBI and co-occurring syndromal depression were identified primarily in bilateral frontal regions, particularly in those with damage to the left frontal lobe and prefrontal cortices, as well as temporal regions including bilateral temporal lobes, the left superior temporal gyrus, and bilateral hippocampi. Various parietal regions and the nucleus accumbens were also implicated. EEG studies showed supporting evidence of functional changes in frontal regions. Conclusion Additional inquiry with attention to TBI without depression control groups, consistent TBI definitions, previous TBI, clinically diagnosed syndromal depression, imaging timing post-injury, acute prospective design, functional neuroimaging, and well-defined neuroanatomical regions of interest is crucial to extrapolating finer discrepancies between primary and TBI-related depression.

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“…Additionally, previous research suggests there are notable differences in the amplitudes of the ERN and Pe in clinical groups when compared with controls (Bailey et al, 2015;Kaiser et al, 2020;Lutz et al, 2021a, b;Michael et al, 2021;Pasion & Barbosa, 2019;Perera et al, 2019). These pre-existing effects on the ERN or Pe may interact with the effect of mindfulness on these ERPs.…”

mentioning

confidence: 92%

Meta-analysis Provides Weak Evidence for an Effect of Mindfulness on Neural Activity Related to Error-Processing in Healthy Individuals Only

et al. 2022

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Objectives Research into the effects of mindfulness meditation indicates improvements in mental health and cognitive function. Mechanisms underpinning these improvements include increased attentional function and decreased emotional reactivity. These functions are engaged when an individual reacts to an error. As such, researchers have examined differences in neural activity between mindful and non-mindful groups during tasks that elicit error responses using electroencephalography (EEG). Event-related potentials associated with error-processing are primarily the error-related negativity (ERN) and error positivity (Pe), which occur ~ 0–150 ms and ~ 200–400 ms following an error. This meta-analysis aimed to determine the effects of mindfulness on ERN and Pe amplitudes. Methods Our literature search revealed 16 studies that examined the ERN (total N = 887, 469 mindfulness, 418 controls) and 12 studies that examined the Pe (total N = 747, 395 mindfulness, 352 controls). Results Results showed a weak association between mindfulness and more negative ERN amplitudes at electrode FCz, with inconsequential Bayesian evidence, after the analysis was restricted to studies including healthy participants only (Q(1) = 4.725, p = 0.030, BF10 = 1.714). The results also provided a preliminary suggestion that mindfulness reduced the Pe amplitude at electrode Pz (Q(2) = 8.023, p = 0.018), when studying individuals that had weeks to years of mindfulness practice (but not less than weeks of mindfulness practice). Conclusions The results do not provide good evidence that mindfulness meditation affects EEG measures of error processing. However, our findings are limited by heterogeneity and potential biases, and as such should be interpreted with caution. Protocol and Registration Systematic Review Registration: PROSPERO CRD42021249775.

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Neural evidence that conscious awareness of errors is reduced in depression following a traumatic brain injury

Cited by 9 publications

References 65 publications

Intact error monitoring in combat Veterans with post-traumatic stress disorder

Intact error monitoring in combat Veterans with post-traumatic stress disorder

Neuroimaging correlates of syndromal depression following traumatic brain injury: A systematic review of the literature

Meta-analysis Provides Weak Evidence for an Effect of Mindfulness on Neural Activity Related to Error-Processing in Healthy Individuals Only

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