Abstract:The effect of electromagnetic radiation on neurons has been studied extensively both experimentally and computationally. As for dendrites, these studies are mostly limited to the morphological aspects such as branching and not basically conductance. The effect of low frequency electric field radiation on the electrophysiological characteristics of dendrites is studied theoretically. The study is based on incorporating the effect of electric field components inside the modified cable equation and considering th… Show more
“…The basic therapeutic studies on the various types of neurological disorders including Alzheimer, Parkinson, Multiple Sclerosis (MS), and traumatic brain injuries requires the real time monitoring of the neural activity (Kempuraj et al, 2017 ). The fundamental studies on the different treatments for the neuron based disorders such as pharmacological treatments, excitation with electric/magnetic fields and stem cell therapy are dependent to the devices in which the electrical activity of the neurons are monitored in real time (Eissa et al, 2018 ; Tekieh et al, 2018 ; Zhong et al, 2018 ). In addition, the advanced studies on the performance of the brain in cognitive neuroscience applications are from demanding areas of monitoring the electrical signaling and activity in different regions of brain (Chen et al, 2016 ; Hindriks et al, 2016 ; Sokolov et al, 2016 ; Deadwyler et al, 2017 ).…”
An all optical, non-destructive method for monitoring neural activity has been proposed and its performance in detection has been analyzed computationally. The proposed method is based on excitation of Surface Plasmon Resonance (SPR) through the structure of optical fibers. The sensor structure consists of a multimode optical fiber where, the cladding of fiber has been removed and thin film of gold structure has been deposited on the surface. Impinging the laser light with appropriate wavelength inside the fiber and based on the total internal reflection, the evanescent wave will excite surface plasmons in the gold thin film. The absorption of light by surface plasmons in the gold structure is severely dependent on the dielectric properties at its vicinity. The electrical activity of neural cells (action potential) can modulate the dielectric properties at its vicinity and hence can modify the absorption of light inside the optical fiber. We have computationally analyzed the performance of the proposed sensor with different available geometries using Finite Element Method (FEM). In this regard, we have shown that the optical response of proposed sensor will track the action potential of the neuron at its vicinity. Based on different geometrical structure, the sensor has absorption in different regions of visible spectrum.
“…The basic therapeutic studies on the various types of neurological disorders including Alzheimer, Parkinson, Multiple Sclerosis (MS), and traumatic brain injuries requires the real time monitoring of the neural activity (Kempuraj et al, 2017 ). The fundamental studies on the different treatments for the neuron based disorders such as pharmacological treatments, excitation with electric/magnetic fields and stem cell therapy are dependent to the devices in which the electrical activity of the neurons are monitored in real time (Eissa et al, 2018 ; Tekieh et al, 2018 ; Zhong et al, 2018 ). In addition, the advanced studies on the performance of the brain in cognitive neuroscience applications are from demanding areas of monitoring the electrical signaling and activity in different regions of brain (Chen et al, 2016 ; Hindriks et al, 2016 ; Sokolov et al, 2016 ; Deadwyler et al, 2017 ).…”
An all optical, non-destructive method for monitoring neural activity has been proposed and its performance in detection has been analyzed computationally. The proposed method is based on excitation of Surface Plasmon Resonance (SPR) through the structure of optical fibers. The sensor structure consists of a multimode optical fiber where, the cladding of fiber has been removed and thin film of gold structure has been deposited on the surface. Impinging the laser light with appropriate wavelength inside the fiber and based on the total internal reflection, the evanescent wave will excite surface plasmons in the gold thin film. The absorption of light by surface plasmons in the gold structure is severely dependent on the dielectric properties at its vicinity. The electrical activity of neural cells (action potential) can modulate the dielectric properties at its vicinity and hence can modify the absorption of light inside the optical fiber. We have computationally analyzed the performance of the proposed sensor with different available geometries using Finite Element Method (FEM). In this regard, we have shown that the optical response of proposed sensor will track the action potential of the neuron at its vicinity. Based on different geometrical structure, the sensor has absorption in different regions of visible spectrum.
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