Electrophysiological activity in the central nucleus of the amygdala, emotionality and stress ulcers in rats.

Henke, Peter G.

doi:10.1037/0735-7044.102.1.77

Cited by 34 publications

(9 citation statements)

References 38 publications

(58 reference statements)

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“…Thus, DA signaling is likely to bias neurotransmission in the CeA and BST towards outputs that promote positive arousing, emotional and affective responses. This is also supported by the ability of DA infused into the CeA to reduce the number and severity of gastric ulcers following stress [259-261], which may involve interactions with the ENK and CRF systems [262,263]. …”

Section: Introductionmentioning

confidence: 99%

Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis

2012

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In this review we propose that there are sex differences in how men and women enter onto the path that can lead to addiction. Males are more likely than females to engage in risky behaviors that include experimenting with drugs of abuse, and in susceptible individuals, they are drawn into the spiral that can eventually lead to addiction. Women and girls are more likely to begin taking drugs as self-medication to reduce stress or alleviate depression. For this reason women enter into the downward spiral further along the path to addiction, and so transition to addiction more rapidly. We propose that this sex difference is due, at least in part, to sex differences in the organization of the neural systems responsible for motivation and addiction. Additionally, we suggest that sex differences in these systems and their functioning are accentuated with addiction. In the current review we discuss historical, cultural, social and biological bases for sex differences in addiction with an emphasis on sex differences in the neurotransmitter systems that are implicated.

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Section: Introductionmentioning

confidence: 99%

Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis

2012

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“…Accordingly, as in the laboratory, rat (Park, 1976;Beattie, 1977;Vincent & Park, 1982;Henke 1988;Scoto, 1990), stomach ulcers can develop within hours in the farm mink. This finding was then the main stimulus for further studies.…”

Section: Discussionmentioning

confidence: 95%

“…The use of restraint stress was based on experiences with laboratory rats. Restraint stress, either alone or in combination with cold exposure, is known to induce stomach ulcers in laboratory rats (Beattie, 1977;Henke, 1988). Repealed restraint stress.…”

Section: Stress Proceduresmentioning

confidence: 99%

“…Acute exposure of rats to several types of stressors, such as immobilization, forced swimming, cold exposure, psychological conflict situation and even the possibility of running, or combinations of these, is known to produce stomach ulcers within a couple of hours (Park, 1976;Beattie, 1977;Vincent & Park, 1982;Henke, 1988;Scoto et al, 1990). Fasting alone causes no ulceration but when combined with another stress it causes an increase in the number of mucosal ulcerations, that is directly related to the duration of starvation (Park, 1976;Auguste et al, 1988).…”

Section: Introductionmentioning

confidence: 99%

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Stomach Ulcer as an Indicator of Stress in Farm Mink

Harri¹,

Nurminen²,

Filén³

1995

Acta Agriculturae Scandinavica, Section A — Animal Science

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“…Electrical or chemical stimulation of the ACE mimics stress-like responses such as increases in arterial blood pressure, heart rate and respiratory rate [39,40], and it induces ulcer formation [41]. Furthermore, lesions of the ACE attenuate or abolish the autonomic or behavioral changes produced by a variety of stresses [4,5].…”

Section: Discussionmentioning

confidence: 99%

Effects of Conditioning Stimulation of the Central Amygdaloid Nucleus on Tooth Pulp-Driven Neurons in the Cat Somatosensory Cortex(SI).

Kawarada

Kamata²,

Matsumoto³

1999

JJP

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The sensation we call pain, like other sensations, can be modulated by exposure to a stressful situation such as a fight or athletic competition. It has been suggested that stress is a physiologic trigger of the intrinsic pain inhibitory system. This phenomenon has been termed as stress-induced analgesia (SIA) (see Amit and Galina [1] for review) or fear-induced analgesia [2]. Actually, acupuncture and transcutaneous electrical nerve stimulation, which might be considered stressful, have been used for analgesia as a clinical procedure [1]. However, the neuronal mechanism and anatomical substrates involved in SIA have remained unclear.It has been demonstrated that the central amygdaloid nucleus (ACE) has an integrative role for coordinating an organism's autonomic, endocrine, and behavioral responses to various stressful stimuli, and that electrical stimulation of the ACE can mimic several of the stress-like responses (see Glavin et al. [3] for review). Lesions of the ACE have been found to block cardiovascular, respiratory, and behavioral parameters of responses to stressors [4,5]. Intracere- Japanese Journal of Physiology, 49, 485-497, 1999 Key words: central amygdaloid nucleus, stress-induced antinociception, somatosensory cortex, tooth pulp-driven neuron, H 1 receptor. Abstract:To study the limbic control of nociception, we examined the effect of conditioning stimulation of the central amygdaloid nucleus (ACE) on tooth pulp-driven (TPD) neurons in the first somatosensory cortex (SI). Cats were anesthetized with N 2 O-O 2 (2 : 1) and 0.5% halothane, and immobilized with tubocurarine chloride. The tooth pulp test stimulus was applied by a single rectangular pulse (0.5 ms in duration and 3-5 times the threshold intensity for the jaw-opening reflex). Conditioning stimuli to the ACE consisted of trains of 33 pulses (300 A) delivered at 330 Hz at intervals of 8-10 s. In 35 out of 61 of the slow (S)-type TPD neurons with latencies of more than 20 ms, conditioning stimulation in the ACE, especially in the medial division, markedly reduced the firing response to the pulpal stimulation. The inhibition of the firing rate in the S-type neurons was 74% of the control. In these S-type neurons, the neurons that were inhibited had significantly longer latencies compared to the noninhibited neurons (45.0Ϯ17.6 ms, nϭ32 vs. 34.8Ϯ10.5 ms, nϭ26). In contrast, the ACE conditioning stimulation affected only one out of 18 fast-type TPD neurons with latencies of less than 20 ms. In addition, ACE stimulation had no effect on the spontaneous discharges of either S-type or F-type neurons. The ACE inhibitory effect on S-type neurons was not diminished by naloxone administration (1 mg/kg, I.V.), while the blockade of histamine H 1 -receptor by diphenhydramine hydrochloride (0.5 mg/kg, I.V.) partially reversed the inhibitory effect. These results suggest that the ACE inhibits ascending nociceptive information to the SI and that this inhibition is mediated in part by histamine (H 1 ) receptors. It seems likely that the antinociceptive ...

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Electrophysiological activity in the central nucleus of the amygdala, emotionality and stress ulcers in rats.

Cited by 34 publications

References 38 publications

Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis

Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis

Stomach Ulcer as an Indicator of Stress in Farm Mink

Effects of Conditioning Stimulation of the Central Amygdaloid Nucleus on Tooth Pulp-Driven Neurons in the Cat Somatosensory Cortex(SI).

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