Electrophoretic Protein Pattern of Human Parotid Saliva in Sjögrens Syndrome and Sialosis

Benedek-Spät, Erika; M, Puskás; J, Rajki

doi:10.3109/00016488009131726

Cited by 10 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stimulated parotid function may therefore be a poor indicator for the extent of salivary gland involvement in SS. This is, however, in contrast to earlier sialochemical findings (42)(43)(44)(45). This is also in contrast to scintigraphic studies that demonstrated more marked involvement of parotid than of submandibular glands in SS patients (46).…”

Section: Collection Of Parotid Salivacontrasting

confidence: 92%

Sialochemistry in Sjögren's syndrome: a review

Thorn

Prause

Oxholm

1989

J Oral Pathology Medicine

View full text Add to dashboard Cite

Sjögren's syndrome (SS) is an autoimmune exocrinopathy. The salivary glands are the site of activated T- and B-lymphocytes, along with gradual parenchymal destruction, diminished flow and altered composition of the secretory product. At present, sialochemistry has achieved no significance for the evaluation of SS patient. However, the number of sialochemical publications is steadily growing. This study review current sialochemical findings in patients with SS and relate the observations to the present concept of diagnosis, pathogenesis and prognosis of SS. An ideal combination of the collection of low-stimulated pure secretion, measurements of absolute flow-rates, and biopsy from the same glands seem to be unobtainable in SS patients. But two procedures may be appropriate: stimulated parotid secretion combined with parotid biopsies, or absorbance of low-stimulated labila saliva combined with labial gland biopsy. Sufficient data on disease-specific alterations in salivary composition in SS are still lacking. However, detection of specific changes in protein synthesis or in glycosylation as well as the detection of inflammatory cell products should be possible with the use of sensitive biochemical assays.

show abstract

Section: Collection Of Parotid Salivacontrasting

confidence: 92%

Sialochemistry in Sjögren's syndrome: a review

Thorn

Prause

Oxholm

1989

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…IgA and IgM rheumatoid factors were found by radioimmunoassay in whole saliva of patients with primary or secondary SS, or rheumatoid arthritis alone (29). Electrophoresis of parotid saliva from patients with SS revealed the presence of either 1 or 2 additional bands in 89% of the specimens (30). Since most of these studies have been applied to only a few diseases and their results are either unconfirmed or controversial, they cannot yet provide diagnostic criteria in SS but are promising investigative techniques.…”

Section: Discussionmentioning

confidence: 99%

Labial salivary gland biopsy in sjögren's syndrome

Daniels

1984

Arthritis & Rheumatism

496

View full text Add to dashboard Cite

Xerostomia is an unsatisfactory diagnostic criterion for the salivary component of Sjögren's syndrome (SS). To determine the diagnostic usefulness of the presence of focal sialadenitis in labial salivary gland (LSG) biopsy specimens, 362 patients suspected of having SS prospectively underwent a unique LSG biopsy procedure. The pattern and severity of LSG inflammation were compared with measurements of parotid flow rate, and the presence or absence of symptomatic xerostomia, major salivary gland enlargement, keratoconjunctivitis sicca (KCS), and other connective tissue diseases (CTD). LSG biopsy focus scores of >1 correlated more closely with the diagnoses of KCS alone and with KCS plus a CTD than did either reduced parotid flow rate or symptoms of xerostomia (P < 0.0005 and P < 0.05, respectively). Focal sialadenitis in an adequate LSG specimen is an objective criterion and a more disease‐specific feature of SS than xerostomia or any other feature of salivary disease. The salivary component of SS should be redefined as the presence of LSG focal sialadenitis.

show abstract

Salivary proteins in rheumatoid arthritis and Sjögren's syndrome: One-dimensional and two-dimensional electrophoretic studies

Beeley

Khoo

1999

Electrophoresis

View full text Add to dashboard Cite

Electrophoretic Protein Pattern of Human Parotid Saliva in Sjögrens Syndrome and Sialosis

Cited by 10 publications

References 13 publications

Sialochemistry in Sjögren's syndrome: a review

Sialochemistry in Sjögren's syndrome: a review

Labial salivary gland biopsy in sjögren's syndrome

Salivary proteins in rheumatoid arthritis and Sjögren's syndrome: One-dimensional and two-dimensional electrophoretic studies

Contact Info

Product

Resources

About