Electrophoretic deposition of hydroxyapatite coatings on AZ31 magnesium substrate for biodegradable implant applications

Asl, Sara Kaabi Falahieh; Németh, Sándor; Tan, Ming Jen

doi:10.1016/j.pcrysgrow.2014.09.004

Cited by 15 publications

(8 citation statements)

References 16 publications

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“…For this purpose, the nanoindentation technique is the most suitable for testing biomaterial surfaces [61,62,63]. The mechanical properties of an implant, mainly Young’s Modulus, should be similar to that of the human bone (10–30 GPa) [64,65]. As the difference between implant and tissue properties increases, the risk of the “shielding” effect increases [65].…”

Section: Discussionmentioning

confidence: 99%

“…The mechanical properties of an implant, mainly Young’s Modulus, should be similar to that of the human bone (10–30 GPa) [64,65]. As the difference between implant and tissue properties increases, the risk of the “shielding” effect increases [65]. It has been confirmed that the occurrence of a shielding effect can cause tissue damage around the implant, bone loss, implant loosening, and premature failure of the implant [64,65,66].…”

Section: Discussionmentioning

confidence: 99%

“…As the difference between implant and tissue properties increases, the risk of the “shielding” effect increases [65]. It has been confirmed that the occurrence of a shielding effect can cause tissue damage around the implant, bone loss, implant loosening, and premature failure of the implant [64,65,66]. According to our nanoindentation tests, the most biomechanical compatibility of tested modifications was noticed for TNF6S and TNF10C with the Young’s Modulus value beng the most similar to the value of Young’s Modulus of human cortical bone.…”

Section: Discussionmentioning

confidence: 99%

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Titania Nanofiber Scaffolds with Enhanced Biointegration Activity—Preliminary In Vitro Studies

Ehlert

Roszek

Jędrzejewski

et al. 2019

IJMS

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The increasing need for novel bone replacement materials has been driving numerous studies on modifying their surface to stimulate osteogenic cells expansion and to accelerate bone tissue regeneration. The goal of the presented study was to optimize the production of titania-based bioactive materials with high porosity and defined nanostructure, which supports the cell viability and growth. We have chosen to our experiments TiO2 nanofibers, produced by chemical oxidation of Ti6Al4V alloy. Fibrous nanocoatings were characterized structurally (X-ray diffraction (XRD)) and morphologically (scanning electron microscopy (SEM)). The wettability of the coatings and their mechanical properties were also evaluated. We have investigated the direct influence of the modified titanium alloy surfaces on the survival and proliferation of mesenchymal stem cells derived from adipose tissue (ADSCs). In parallel, proliferation of bone tissue cells—human osteoblasts MG-63 and connective tissue cells - mouse fibroblasts L929, as well as cell viability in co-cultures (osteoblasts/ADSCs and fibroblasts/ADSCs has been studied. The results of our experiments proved that among all tested nanofibrous coatings, the amorphous titania-based ones were the most optimal scaffolds for the integration and proliferation of ADSCs, fibroblasts, and osteoblasts. Thus, we postulated these scaffolds to have the osteopromotional potential. However, from the co-culture experiments it can be concluded that ADSCs have the ability to functionalize the initially unfavorable surface, and make it suitable for more specialized and demanding cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Titania Nanofiber Scaffolds with Enhanced Biointegration Activity—Preliminary In Vitro Studies

Ehlert

Roszek

Jędrzejewski

et al. 2019

IJMS

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“…Fabrication of TNT layers at 5 V (Ti6Al4V/TNT5) results in a significant decrease in the elastic modulus and nanohardness compared to the unmodified Ti6Al4V substrate. This effect is positive in the case of materials for long-term implants because it decreases the otherwise significant difference in mechanical properties between the implant and the bone and, consequently, a risk of the stress shielding effect [49]. The deposition of the HA coating on the surfaces of Ti6Al4V/TNT5 increased the H/E and H 3 /E 2 ratios (H/E = wear resistance coefficient; H = hardness, E = Young’s modulus) compared to the uncoated Ti6Al4V/TNT system.…”

Section: Discussionmentioning

confidence: 99%

Titania Nanotubes/Hydroxyapatite Nanocomposites Produced with the Use of the Atomic Layer Deposition Technique: Estimation of Bioactivity and Nanomechanical Properties

et al. 2019

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Titanium dioxide nanotubes/hydroxyapatite nanocomposites were produced on a titanium alloy (Ti6Al4V/TNT/HA) and studied as a biocompatible coating for an implant surface modification. As a novel approach for this type of nanocomposite fabrication, the atomic layer deposition (ALD) method with an extremely low number of cycles was used to enrich titania nanotubes (TNT) with a very thin hydroxyapatite coating. X-ray diffraction (XRD) and scanning electron microscopy (SEM) were used for determination of the structure and the surface morphology of the fabricated nanocoatings. The biointegration activity of the layers was estimated based on fibroblasts’ proliferation on the TNT/HA surface. The antibacterial activity was determined by analyzing the ability of the layers to inhibit bacterial colonization and biofilm formation. Mechanical properties of the Ti6Al4V/TNT/HA samples were estimated by measuring the hardness, Young’s module, and susceptibility to scratching. The results revealed that the nanoporous titanium alloy coatings enriched with a very thin hydroxyapatite layer may be a promising way to achieve the desired balance between biofunctional and biomechanical properties of modern implants.

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“…This thin titanium film-covered silicone was used as a substrate electrode in the deposition process 208 . Many studies have been reported the deposition of HA on Mg alloys by the electrophoretic deposition technique [209][210][211] .…”

Section: Electrophoretic Depositionmentioning

confidence: 99%

Surface engineering of biodegradable implants: emerging trends in bioactive ceramic coatings and mechanical treatments

2021

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Electrophoretic deposition of hydroxyapatite coatings on AZ31 magnesium substrate for biodegradable implant applications

Cited by 15 publications

References 16 publications

Titania Nanofiber Scaffolds with Enhanced Biointegration Activity—Preliminary In Vitro Studies

Titania Nanofiber Scaffolds with Enhanced Biointegration Activity—Preliminary In Vitro Studies

Titania Nanotubes/Hydroxyapatite Nanocomposites Produced with the Use of the Atomic Layer Deposition Technique: Estimation of Bioactivity and Nanomechanical Properties

Surface engineering of biodegradable implants: emerging trends in bioactive ceramic coatings and mechanical treatments

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