Electrophoretic deposition of dexamethasone-loaded gelatin nanospheres/chitosan coating and its dual function in anti-inflammation and osteogenesis

Hu, Qi; Chen, Qiang; Ren, Hailong; Wu, Xuesong; Liu, Xianhu; Lu, Tingli

doi:10.1016/j.colsurfb.2018.05.029

Cited by 47 publications

(28 citation statements)

References 41 publications

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“…MPP nanoparticles were endowed with the anti‐inflammatory property by loading DXMS. DXMS is kind of glucocorticoid, which up‐regulates IL‐10, interferon‐γ (INF‐γ) and reduces interleukin 8 (IL‐8) to induce an anti‐inflammatory effect . Here, DXMS (0.85 ± 0.04 µg mg −1 ) was encapsulated into MPP, which was calculated according to the standard curve (Figure S8, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

A Multi‐Functional Silicon Nanoparticle Designed for Enhanced Osteoblast Calcification and Related Combination Therapy

Shao

Guan

et al. 2019

Macromolecular Bioscience

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Implant materials applied in bone defect commonly focus on the inducement of bone regeneration and neglect to cure complications including bacterial infection and inflammation, which may result in delayed unions or even amputation. In this study, a microporous silica nanoparticle‐poly(N‐isopropylacrylamide‐b‐(2‐(dimethylamino)ethyl methacrylate) is synthesized for loading DXMS and the ECM‐derived peptide (Sequence: Succinic acid‐GTPGPQGIAGQRGVV) in order to enhance the osteoblast calcification and relieve related symptoms. Positively charged PDMA blocks endow the nanoparticle with the antimicrobial property. Moreover, the combination of DXMS makes it have the ability of anti‐inflammation and promoting calcification formation. Furthermore, incorporation of the peptide leads to a significant improvement of mineralization and alkaline phosphatase expression in the preosteoblast. After intramuscular implantation in mice for four weeks, the results indicate the composite nanoparticle can promote ectopic bone formation. These combined properties make the composite silicon nanoparticle a promising osteogenic drug appropriate for further study in bone repair and related combination therapy.

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Section: Resultsmentioning

confidence: 99%

A Multi‐Functional Silicon Nanoparticle Designed for Enhanced Osteoblast Calcification and Related Combination Therapy

Shao

Guan

et al. 2019

Macromolecular Bioscience

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“…During the process of bone regeneration, it is very important to create an environment which is conducive to the anti-inflammatory and osteogenesis of biomaterials via biomaterials modification [ [54] , [55] , [56] ]. Macrophages play a key role in all phases of wound healing and orchestrate the bone formation process.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-4 assisted calcium-strontium-zinc-phosphate coating induces controllable macrophage polarization and promotes osseointegration on titanium implant

Zhao

Zuo

Wang

et al. 2021

Materials Science and Engineering: C

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Titanium (Ti) and its alloys are believed to be promising scaffold materials for dental and orthopedic implantation due to their ideal mechanical properties and biocompatibility. However, the host immune response always causes implant failures in the clinic. Surface modification of the Ti scaffold is an important factor in this process and has been widely studied to regulate the host immune response and to further promote bone regeneration. In this study, a calcium-strontium-zinc-phosphate (CSZP) coating was fabricated on a Ti implant surface by phosphate chemical conversion (PCC) technique, which modified the surface topography and element constituents. Here, we envisioned an accurate immunomodulation strategy via delivery of interleukin (IL)-4 to promote CSZP-mediated bone regeneration. IL-4 (0 and 40 ng/mL) was used to regulate immune response of macrophages. The mechanical properties, biocompatibility, osteogenesis, and anti-inflammatory properties were evaluated. The results showed that the CSZP coating exhibited a significant enhancement in surface roughness and hydrophilicity, but no obvious changes in proliferation or apoptosis of bone marrow mesenchymal stem cells (BMMSCs) and macrophages. In vitro, the mRNA and protein expression of osteogenic related factors in BMMSCs cultured on a CSZP coating, such as ALP and OCN, were significantly higher than those on bare Ti. In vivo, there was no enhanced bone formation but increased macrophage type 1 (M1) polarization on the CSZP coating. IL-4 could induce M2 polarization and promote osteogenesis of BMMSCs on CSZP in vivo and in vitro. In conclusion, the CSZP coating is an effective scaffold for BMMSCs osteogenesis, and IL-4 presents the additional advantage of modulating the immune response for bone regeneration on the CSZP coating in vivo.

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“…Most of the aforementioned works reported SEM analysis, together with the other characterizations, in order to gain insights into the morphology of titanium polymeric coatings obtained by electrochemical routes [34,51,[53][54][55][56][57][58][61][62][63]81].…”

Section: Scanning Electron Microscopy With Energy-dispersive X-ray Anmentioning

confidence: 99%

“…Since titanium or titanium alloys' surface wettability is important, it is intuitive that this property represents a crucial parameter in the choice of the most suitable polymer coating, which covers the metal surface, therefore changing its hydrophilic or hydrophobic nature. As far as the electrodeposited polymer films on titanium are concerned, CA is often employed in combination with most of the abovementioned surface analysis techniques [31,38,53,57,63,81,97] (Figure 5). For example, in the case of polypyrrole/poly(styrene sulphonate) composite coatings electrodeposited on Ti6Al7Nb alloy, Pirvu et al demonstrated that wettability can be controlled by changing the pyrrole:poly(styrene sulphonate) polymerization ratio.…”

Section: Contact Anglementioning

confidence: 99%

Surface Characterization of Electro-Assisted Titanium Implants: A Multi-Technique Approach

et al. 2020

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The understanding of chemical–physical, morphological, and mechanical properties of polymer coatings is a crucial preliminary step for further biological evaluation of the processes occurring on the coatings’ surface. Several studies have demonstrated how surface properties play a key role in the interactions between biomolecules (e.g., proteins, cells, extracellular matrix, and biological fluids) and titanium, such as chemical composition (investigated by means of XPS, TOF-SIMS, and ATR-FTIR), morphology (SEM–EDX), roughness (AFM), thickness (Ellipsometry), wettability (CA), solution–surface interactions (QCM-D), and mechanical features (hardness, elastic modulus, adhesion, and fatigue strength). In this review, we report an overview of the main analytical and mechanical methods commonly used to characterize polymer-based coatings deposited on titanium implants by electro-assisted techniques. A description of the relevance and shortcomings of each technique is described, in order to provide suitable information for the design and characterization of advanced coatings or for the optimization of the existing ones.

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Electrophoretic deposition of dexamethasone-loaded gelatin nanospheres/chitosan coating and its dual function in anti-inflammation and osteogenesis

Cited by 47 publications

References 41 publications

A Multi‐Functional Silicon Nanoparticle Designed for Enhanced Osteoblast Calcification and Related Combination Therapy

A Multi‐Functional Silicon Nanoparticle Designed for Enhanced Osteoblast Calcification and Related Combination Therapy

Interleukin-4 assisted calcium-strontium-zinc-phosphate coating induces controllable macrophage polarization and promotes osseointegration on titanium implant

Surface Characterization of Electro-Assisted Titanium Implants: A Multi-Technique Approach

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