A Multi‐Functional Silicon Nanoparticle Designed for Enhanced Osteoblast Calcification and Related Combination Therapy

Shao, Nan; Guan, Yuyao; Li, Sha; Li, Xiaoyuan; Zhou, Dongfang; Huang, Yubin

doi:10.1002/mabi.201900255

Cited by 4 publications

(1 citation statement)

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“…Due to the reduction of water solubility, the burst release was reduced by the precipitation of the hydrophilic vancomycin hydrochloride 206 . A novel multifunctional carrier composed of microporous silica nanoparticles and poly(N‐isopropylacrylamide‐b‐(2‐(dimethylamino)ethyl methacrylate) (MSN‐PNI‐PDMA) has been found effective in reducing inflammation and infection and enhancing osteogenesis by loading dexamethasone (DXMS) and an ECM‐derived peptide 207 . There are various reports on the delivery of antimicrobial compounds within TNTs for bone regeneration in the literature 208 .…”

Section: Other Acellular Bone Scaffold Materialsmentioning

confidence: 99%

A review of biomimetic scaffolds for bone regeneration: Toward a cell‐free strategy

Jiang

Wang

2020

Bioengineering & Transla Med

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In clinical terms, bone grafting currently involves the application of autogenous, allogeneic, or xenogeneic bone grafts, as well as natural or artificially synthesized materials, such as polymers, bioceramics, and other composites. Many of these are associated with limitations. The ideal scaffold for bone tissue engineering should provide mechanical support while promoting osteogenesis, osteoconduction, and even osteoinduction. There are various structural complications and engineering difficulties to be considered. Here, we describe the biomimetic possibilities of the modification of natural or synthetic materials through physical and chemical design to facilitate bone tissue repair. This review summarizes recent progresses in the strategies for constructing biomimetic scaffolds, including ion‐functionalized scaffolds, decellularized extracellular matrix scaffolds, and micro‐ and nano‐scale biomimetic scaffold structures, as well as reactive scaffolds induced by physical factors, and other acellular scaffolds. The fabrication techniques for these scaffolds, along with current strategies in clinical bone repair, are described. The developments in each category are discussed in terms of the connection between the scaffold materials and tissue repair, as well as the interactions with endogenous cells. As the advances in bone tissue engineering move toward application in the clinical setting, the demonstration of the therapeutic efficacy of these novel scaffold designs is critical.

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Section: Other Acellular Bone Scaffold Materialsmentioning

confidence: 99%