Electrophoresis of human brain microvascular endothelial cells with uptake of cationic solid lipid nanoparticles: Effect of surfactant composition

Nanoparticle Formulation Improves the Anticonvulsant Effect of Clonazepam on the Pentylenetetrazole-Induced Seizures: Behavior and Electroencephalogram

“…On the contrary, the increase of the therapeutic effect exclusively by passage through the BBB could be explained by the following mechanisms: (1) adsorption of SLN into the capillary walls followed by a release from this site to the brain; and (2) adhesion to the endothelial cell membrane followed by endocytosis by the endothelial cells and the release (passive diffusion) of the drug within these cells for delivery to the brain . Our results suggest that these mechanisms are likely to be involved in the increase in anticonvulsant efficacy observed with CLZ‐SLN compared with CLZ in solution.…”

Physicochemical properties of nevirapine-loaded solid lipid nanoparticles and nanostructured lipid carriers

“…In this study, zeta potential was about 17.5 mV, which was not high as compared with the thermal potential of 25.7 mV. However, the coating of hydrophilic Tween 80 could further improve the stability of the lipid suspension by hydration in the surface layer [35,36]. Fig.…”

Targeting nevirapine delivery across human brain microvascular endothelial cells using transferrin-grafted poly(lactide-co-glycolide) nanoparticles

“…In addition, the positive charge on DODAB could absorb the negatively charged biomolecules by electrostatic interaction [62]. Moreover, the electrical energy between nanoparticles coated with DODAB and negatively charged HBMECs was attractive [63]. As indicated in Figure 6, an increase in the weight percentage of NVP enhanced the loading efficiency of Tf.…”