Physicochemical properties of nevirapine-loaded solid lipid nanoparticles and nanostructured lipid carriers

Kuo, Yung‐Chih; Chung, Jui-Fang

doi:10.1016/j.colsurfb.2010.11.037

Cited by 112 publications

(32 citation statements)

References 43 publications

(41 reference statements)

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“…NLCs achieved the sustained release of tryptanthrin without an initial burst. Other studies on NLCs have shown that in a fixed ratio of solid lipids, SLNs entrapped more nevirapine than NLCs (Kuo and Chung, 2011). The incorporation of OA also reduced the thermal resistance of NLCs and accelerated the release of nevirapine from the nanocarriers.…”

Section: Drug Releasementioning

confidence: 97%

Galactosylated nanostructured lipid carriers for delivery of 5-FU to hepatocellular carcinoma

Varshosaz

Hassanzadeh

Sadeghi

et al. 2012

Journal of Liposome Research

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The aim of the present study was to design a targeted delivery system of 5-fluorouracil (5-FU) for hepatocellular carcinoma (HCC). Lactobionic acid (LB) was conjugated to stearyl amine (SA) by a chemical reaction. The nanostructured lipid carriers (NLCs), containing LB conjugate, lecithin, glyceryl monostearate, oil [oleic acid (OA) or Labrafac 5 or 10%], and 5-FU, were dissolved in alcohol/acetone, the oil phase was added to the aqueous phase containing Tween 80 or Solutol(®) HS15 (0.25 or 0.5%), and NLCs were prepared by an emulsification-solvent diffusion method. Physical properties and drug release were studied in NLCs. The thiazolyl blue tetrazolium bromide assay was used to study the cytotoxicity of NLCs on HepG(2) cells, and the cellular uptake of NLCs was determined by flow cytometry. Fourier transform infrared spectroscopy and (1)H-NMR spectra confirmed the successful conjugation of LB and SA. The optimized NLCs consisted of 0.5% Solutol HS15 and 10% OA oil. The particle size of these nanoparticles was 139.2 nm, with a zeta potential of -18 mV, loading efficiency of 34.2%, release efficiency after 2 hours of the release test was 72.6%, and crystallinity was 0.63%. The galactosylated NLCs of 5-FU were cytotoxic on the HepG(2) cell line in a half concentration of 5-FU and seems promising in reducing 5-FU dose in HCC.

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Section: Drug Releasementioning

confidence: 97%

Galactosylated nanostructured lipid carriers for delivery of 5-FU to hepatocellular carcinoma

Varshosaz

Hassanzadeh

Sadeghi

et al. 2012

Journal of Liposome Research

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“…24,25 However, NGF-SM-ApoE-LIP might cause lipid fusion with cell membrane and provoke a slight inflammatory response. [26][27][28] Based on Figure 2A, NGF-SM-ApoE-LIP did not apparently jeopardize HBMECs and HAs when delivering NGF across the BBB.…”

mentioning

confidence: 88%

Rescuing cholinergic neurons from apoptotic degeneration by targeting of serotonin modulator- and apolipoprotein E-conjugated liposomes to the hippocampus

Kuo¹,

Lee²

2016

IJN

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“…[32] The dialysis bag (molecular weight cut off between 8000 and 14000) was soaked in double-distilled water for 12 h before using. BCA-SLN (equivalent to 1 mg of BCA) solution was poured into dialysis bag with the two ends fixed by thread and completely immersed in 250 ml of pH 7.4 phosphate buffer solution (PBS).…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Preparation and characterization of Biochanin A loaded solid lipid nanoparticles

Chen¹,

Tao²,

Cheng³

et al. 2012

Asian J Pharm

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B iochanin A, the predominant isoflavones found in plants, had proved its human health benefits. The purpose of this research was to study whether Biochanin A (BCA) loaded solid lipid nanoparticles (SLN) could improve solution and prolong the half-life of BCA. BCA-SLN was prepared by emulsion evaporation and low temperature solidification technique, and freeze-dried powders were developed to improve stability. The mean particle sizes, zeta potential, entrapment efficiency (EE), and drug loading capacity (DL) of BCA was 176.0 nm, −18.7 ± 0.26, 97.15 ± 0.28%, and 6.38 ± 0.04%, respectively. The results of differential scanning calorimetry (DSC) and X-ray diffraction analysis (XRD) indicated that the BCA was wrapped and absorbed in the nanoparticles. The solution of preparation is much higher than the untreated BCA. Results of stability of SLN showed a relatively short-term stability after storage at 4°C and 25°C for 15 days. Drug release of untreated BCA and BCA-SLN was fit into the Biexponential equations and Weibull equations, respectively, and SLN showed sustained release properties. But after freeze-dried, stability was improved, and the EE and DL had a slightly decrease. The mean particle size was slightly increased, but the structure was not changed. In conclusion, SLN systems can represent an effective strategy to change the poor aqueous solubility and prolong the half-time of BCA. Optimized content for mobile and hand-held devicesHTML pages have been optimized of mobile and other hand-held devices (such as iPad, Kindle, iPod) for faster browsing speed. Click on [Mobile Full text] from Table of Contents page. This is simple HTML version for faster download on mobiles (if viewed on desktop, it will be automatically redirected to full HTML version)

show abstract

Physicochemical properties of nevirapine-loaded solid lipid nanoparticles and nanostructured lipid carriers

Cited by 112 publications

References 43 publications

Galactosylated nanostructured lipid carriers for delivery of 5-FU to hepatocellular carcinoma

Galactosylated nanostructured lipid carriers for delivery of 5-FU to hepatocellular carcinoma

Rescuing cholinergic neurons from apoptotic degeneration by targeting of serotonin modulator- and apolipoprotein E-conjugated liposomes to the hippocampus

Preparation and characterization of Biochanin A loaded solid lipid nanoparticles

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