Electrophoresis-enhanced localized surface plasmon resonance sensing based on nanocup array for thrombin detection

Li, Shuang; Zhang, Diming; Zhang, Qian; Lu, Yanli; Li, Nantao; Chen, Qun-wei; Liu, Qingjun

doi:10.1016/j.snb.2016.03.134

Cited by 25 publications

(16 citation statements)

References 43 publications

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“…With its biocompatibility, PEG is widely used as a biosensor with antifouling characteristics. In recent studies, PEG and its hybrids have been employed for the fabrication of electrochemical [ 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 ], optical [ 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 ], and mass based [ 99 , 100 , 101 , 102 ] biosensors.…”

Section: Hydrogels For Biosensingmentioning

confidence: 99%

Hydrogel Based Sensors for Biomedical Applications: An Updated Review

2017

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Abstract:Biosensors that detect and convert biological reactions to a measurable signal have gained much attention in recent years. Between 1950 and 2017, more than 150,000 papers have been published addressing the applications of biosensors in different industries, but to the best of our knowledge and through careful screening, critical reviews that describe hydrogel based biosensors for biomedical applications are rare. This review discusses the biomedical application of hydrogel based biosensors, based on a search performed through Web of Science Core, PubMed (NLM), and Science Direct online databases for the years 2000-2017. In this review, we consider bioreceptors to be immobilized on hydrogel based biosensors, their advantages and disadvantages, and immobilization techniques. We identify the hydrogels that are most favored for this type of biosensor, as well as the predominant transduction strategies. We explain biomedical applications of hydrogel based biosensors including cell metabolite and pathogen detection, tissue engineering, wound healing, and cancer monitoring, and strategies for small biomolecules such as glucose, lactate, urea, and cholesterol detection are identified.

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Section: Hydrogels For Biosensingmentioning

confidence: 99%

Hydrogel Based Sensors for Biomedical Applications: An Updated Review

2017

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Section: Localised Surface Plasmon Resonance Sensors For Biomedical Dmentioning

confidence: 99%

“…Hence, AgNPs are subjected to functionalisation prior to their application in sensor development [91]. Due to higher stability as well as a superior capability to undergo functionalisation with various biomolecules, AuNPs are emerging as the material of choice to develop LSPR transducers [84,92,93] even though the magnitude of their relative scattering efficiency is lower than that of AgNPs [86]. Although aluminum nanoparticles display an analogous oxidation behavior to AgNPs, it is emerging as an important material for transduction in LSPR because of lucrative preparation strategies that allow spectral tunability within the ultraviolet (UV)/ visible (vis) range [59,86,94,95].…”

Section: Localised Surface Plasmon Resonance Sensors For Biomedical Dmentioning

confidence: 99%

“…The sensor was fabricated using a composite of tungsten sulphide nanorod array on titanium mesh with DNA functionalised AuNPs (size = 18 ± 1 nm) as a sensor platform and a multiplexed signal amplifier in the form of a nanohybrid of AgNPs (lattice spacing = 0.27 nm) and zinc metal-organic framework nanozyme. Other geometries that have been widely explored in recent years for developing LSPR sensors include nanopyramids [95,104,105], nanourchins [106][107][108][109], nanocups [92,[110][111][112][113], nanoholes [114][115][116][117] and nanoislands [118][119][120][121][122].…”

Section: Localised Surface Plasmon Resonance Sensors For Biomedical Dmentioning

confidence: 99%

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Recent Progress in Optical Sensors for Biomedical Diagnostics

Pirzada

Altıntaş

2020

Micromachines

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In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.

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“…Thrombin levels can be elevated during extra- and intravascular activation of blood coagulation by tumor cells [2]. Thrombin is also involved in diseases such as atherosclerosis, thromboembolic disease, cancer, and inflammatory disease [3,4], and detecting this protein in blood is important for both research and clinical applications [5]. Due to its clinical importance, there is a wide range of work aimed at detecting thrombin and most of it is based on aptamers [1].…”

Section: Introductionmentioning

confidence: 99%

Etched Fiber Bragg Grating Biosensor Functionalized with Aptamers for Detection of Thrombin

Bekmurzayeva

Dukenbayev

Shaimerdenova

et al. 2018

Sensors

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A biosensor based on an etched Fiber Bragg Grating (EFBG) for thrombin detection is reported. The sensing system is based on a Fiber Bragg Grating (FBG) with a Bragg wavelength of 1550 nm, wet-etched in hydrofluoric acid (HF) for ~27 min, to achieve sensitivity to a refractive index (RI) of 17.4 nm/RIU (refractive index unit). Subsequently, in order to perform a selective detection of thrombin, the EFBG has been functionalized with silane-coupling agent 3-(aminopropyl)triethoxysilane (APTES) and a cross-linker, glutaraldehyde, for the immobilization of thrombin-binding aptamer. The biosensor has been validated for thrombin detection in concentrations ranging from 10 nM to 80 nM. The proposed sensor presents advantages with respect to other sensor configurations, based on plasmonic resonant tilted FBG or Long Period Grating (LPG), for thrombin detection. Firstly, fabricating an EFBG only requires chemical etching. Moreover, the functionalization method used in this study (silanization) allows the avoidance of complicated and expensive fabrications, such as thin film sputtering or chemical vapor deposition. Due to their characteristics, EFBG sensors are easier to multiplex and can be used in vivo. This opens new possibilities for the detection of thrombin in clinical settings.

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Electrophoresis-enhanced localized surface plasmon resonance sensing based on nanocup array for thrombin detection

Cited by 25 publications

References 43 publications

Hydrogel Based Sensors for Biomedical Applications: An Updated Review

Hydrogel Based Sensors for Biomedical Applications: An Updated Review

Recent Progress in Optical Sensors for Biomedical Diagnostics

Etched Fiber Bragg Grating Biosensor Functionalized with Aptamers for Detection of Thrombin

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