Electronic tongue for the detection of taste-masking microencapsulation of active pharmaceutical substances

Jańczyk, M.; Kutyła, A.; Sollohub, Krzysztof; Wosicka, Hanna; Cal, Krzysztof; Ciosek, Patrycja

doi:10.1016/j.bioelechem.2010.08.006

Cited by 43 publications

(32 citation statements)

References 23 publications

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“…Since then, multichannel taste sensor that later became a fundamental part of commercial taste sensing system by Insent had been used for quantification of basic taste sensations in large variety of samples [2][3][4]. Various studies were devoted to the application of different versions of e-tongues for the assessment of taste in pharmaceutical samples [5][6][7][8][9][10][11][12][13][14][15][16]. A variety of sensors and sensor systems were developed and applied in these research efforts, based on both, commercial [5,6,9,10,[13][14][15] or laboratory instrumentation [7,8,11,16].…”

Section: Introductionmentioning

confidence: 99%

“…Most of these reports are focused on the development of new drug formulations by choosing appropriate taste masking strategies. Besides, original and generic products were compared [12,13], products modified with commercially available beverages or jellies characterized [14,15], the effect of micro encapsula-tion [16] or oral film formulations [17] on taste-masking efficacy assessed and stability and dose uniformity studies [18] presented. In a recent study, the capability of HPLC and e-tongue analysis was compared with human taste panels regarding taste assessment and the applied e-tongue was proven to be even more sensitive than the human taste panels [19].…”

Section: Introductionmentioning

confidence: 99%

“…The electronic tongue TS-5000Z and SA402B (Insent Inc., AtsugiShi, Japan) and those multisensor systems from the laboratories of Warsaw (Department of Microbioanalytics, Warsaw University of Technology; Poland) and St. Petersburg (Institute of Chemistry, St. Petersburg State University/Laboratory of Artificial Sensory Systems, ITMO University; Russia) are based on direct potentiometric measurements with sensors based on PVC-plasticized membranes [4,7,8,10,16]. The differences between these systems are in the number and composition of sensor membranes leading to the fact that all these systems have somewhat different sensitivity to the components in the analyzed media.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Independent comparison study of six different electronic tongues applied for pharmaceutical analysis

Pein

Kirsanov

Ciosek

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

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a b s t r a c tElectronic tongue technology based on arrays of cross-sensitive chemical sensors and chemometric data processing has attracted a lot of researchers' attention through the last years. Several so far reported applications dealing with pharmaceutical related tasks employed different e-tongue systems to address different objectives. In this situation, it is hard to judge on the benefits and drawbacks of particular e-tongue implementations for R&D in pharmaceutics. The objective of this study was to compare the performance of six different e-tongues applied to the same set of pharmaceutical samples. For this purpose, two commercially available systems (from Insent and AlphaMOS) and four laboratory prototype systems (two potentiometric systems from Warsaw operating in flow and static modes, one potentiometric system from St. Petersburg, one voltammetric system from Barcelona) were employed. The sample set addressed in the study comprised nine different formulations based on caffeine citrate, lactose monohydrate, maltodextrine, saccharin sodium and citric acid in various combinations. To provide for the fair and unbiased comparison, samples were evaluated under blind conditions and data processing from all the systems was performed in a uniform way. Different mathematical methods were applied to judge on similarity of the e-tongues response from the samples. These were principal component analysis (PCA), RV matrix correlation coefficients and Tuckerís congruency coefficients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Independent comparison study of six different electronic tongues applied for pharmaceutical analysis

Pein

Kirsanov

Ciosek

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

Self Cite

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“…Similarly, Gutiérrez et al (2011) used principal component analysis (PCA) and soft independent modeling by class analogy (SIMCA) for the quantification of grape varieties. Further, Jańczyk et al (2010) used ion selective electrode for detection of micro-encapsulation effect of pharmaceutical ingredients. As far as the classification of water containments are concerned, Martínez-Máñez et al (2005) developed an electronic tongue for the qualitative analysis of natural waters using Fuzzy ARTMAP neural network with success rate higher than 93%.…”

Section: Introductionmentioning

confidence: 99%

Classification of heavy metal ions present in multi-frequency multi-electrode potable water data using evolutionary algorithm

et al. 2016

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Access to potable water for the common people is one of the most challenging tasks in the present era. Contamination of drinking water has become a serious problem due to various anthropogenic and geogenic events. The paper demonstrates the application of evolutionary algorithms, viz., particle swan optimization and genetic algorithm to 24 water samples containing eight different heavy metal ions (Cd, Cu, Co, Pb, Zn, Ar, Cr and Ni) for the optimal estimation of electrode and frequency to classify the heavy metal ions. The work has been carried out on multi-variate data, viz., single electrode multi-frequency, single frequency multi-electrode and multi-frequency multi-electrode water samples. The electrodes used are platinum, gold, silver nanoparticles and glassy carbon electrodes. Various hazardous metal ions present in the water samples have been optimally classified and validated by the application of Davis Bouldin index. Such studies are useful in the segregation of hazardous heavy metal ions found in water resources, thereby quantifying the degree of water quality.

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“…Electronic tongue receives information from chemicals through an electrode array, which works in a process similar to human receptors (19)(20)(21). Influence of the drug/polymer ratio and concentration of polymer solution on the characteristics of prepared microparticles was also studied.…”

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confidence: 99%

Characterization and taste masking evaluation of microparticles with cetirizine dihydrochloride and methacrylate-based copolymer obtained by spray drying

et al. 2017

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Taste of a pharmaceutical formulation is an important parameter for the effectiveness of pharmacotherapy. Cetirizine dihydrochloride (CET) is a second-generation antihistamine that is commonly administered in allergy treatment. CET is characterized by extremely bitter taste and it is a great challenge to successfully mask its taste; therefore the goal of this work was to formulate and characterize the microparticles obtained by the spray drying method with CET and poly(butyl methacrylate-co-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate 1:2:1 copolymer (Eudragit E PO) as a barrier coating. Assessment of taste masking by the electronic tongue has revealed that designed formulations created an effective taste masking barrier. Taste masking effect was also confirmed by the in vivo model and the in vitro release profile of CET. Obtained data have shown that microparticles with a drug/polymer ratio (0.5:1) are promising CET carriers with efficient taste masking potential and might be further used in designing orodispersible dosage forms with CET.Keywords: taste masking, electronic tongue, cetirizine dihydrochloride, microparticles, methacrylate copolymer, spray drying Unacceptable taste is an important problem encountered in the designing of new dosage forms. Taste masking of drug substances has been continuously changing with emerging techniques and new excipients (1-7). Taste masking can be carried out by various methods, depending on the therapeutic agent and dosage form. One of the simplest taste masking methods is addition of flavors, sweeteners and effervescent agents, but it is not always effective. In recent years, methods creating a physical barrier between active ingredients and taste buds have been developed for taste masking. One of them is spray drying, a relatively simple and convenient technology for the preparation of microparticles (8)(9)(10)(11)

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Electronic tongue for the detection of taste-masking microencapsulation of active pharmaceutical substances

Cited by 43 publications

References 23 publications

Independent comparison study of six different electronic tongues applied for pharmaceutical analysis

Independent comparison study of six different electronic tongues applied for pharmaceutical analysis

Classification of heavy metal ions present in multi-frequency multi-electrode potable water data using evolutionary algorithm

Characterization and taste masking evaluation of microparticles with cetirizine dihydrochloride and methacrylate-based copolymer obtained by spray drying

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