Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells

Chen, I‐Ling; Todd, Ian; Tighe, Patrick J.; Fairclough, Lucy

doi:10.1007/s00204-020-02757-8

Cited by 15 publications

(4 citation statements)

References 65 publications

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“…Com isso, pode-se ter diminuição da depuração celular, diminuição da resposta inflamatória dos tecidos danificados, desequilíbrio nos mecanismos de reparo celular e redução da função pulmonar, medida pelo volume expiratório forçado no primeiro segundo (VEF1) e pela relação entre o volume expiratório forçado e a capacidade vital forçada (VEF/CVF). Além disso, há aumento nas mucinas MUC4 e MUC5AC para MUC5B comparado com não fumantes e piroptose celular que ficam elevadas no fluido do lavado broncoalveolar de usuários de cigarro eletrônico (Hooper & Garfield, 2019;Chen, et al, 2020;D'Almeida et al, 2020).…”

Section: Evali E Outros Efeitos Pulmonaresunclassified

Complicações pulmonares e extrapulmonares associadas ao uso de cigarros eletrônicos: uma revisão integrativa

Cardoso¹,

Silva²,

Bezerra³

et al. 2022

RSD

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Objetivo: investigar as complicações pulmonares e extrapulmonares associadas ao uso de cigarros eletrônicos, considerando seu crescimento observado atualmente. Metodologia: realizou-se uma revisão integrativa de literatura, durante os anos de 2021 e 2022, por meio de buscas nas principais plataformas científicas, utilizando os descritores “vaping”, “adverse effects” e “e-cigarrette vapor”, escolhidos de acordo com o DeCS (Descritores em Ciências da Saúde) e combinando-os com o operador booleano “AND”. Resultados e discussão: através dos descritores anteriormente citados, foram encontrados 309 artigos, dos quais foram selecionados 18 para a revisão integrativa e constituição da amostra final. Em vista disso, com a análise dos estudos supracitados, evidenciou-se que os cigarros eletrônicos estão relacionados com o surgimento da EVALI (E-cigarette or Vaping Product Use-Associated Lung Injury), com o aumento da suscetibilidade a infecções, doenças cardiovasculares, efeitos citotóxicos e inflamatórios, além de comprometimento cerebrovascular. Conclusão: diante do exposto, concluiu-se que o consumo de cigarro eletrônico possui repercussões sistêmicas, a nível pulmonar e extrapulmonar. O estudo evidenciou as implicações do cigarro eletrônico no sistema cardiovascular, respiratório, neural, genético e imunológico, os quais afetam a saúde e a qualidade de vida do indivíduo de maneira generalizada.

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Section: Evali E Outros Efeitos Pulmonaresunclassified

Complicações pulmonares e extrapulmonares associadas ao uso de cigarros eletrônicos: uma revisão integrativa

Cardoso¹,

Silva²,

Bezerra³

et al. 2022

RSD

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show abstract

“…Data showing the immunological effects of e-cigarettes in humans are complemented by a range of in vitro studies using immune cells. For example, it has been shown that exposure to e-cigarette aerosol extract increases the production of proinflammatory cytokines such as IL-6 by immune cells such as macrophages [ 83 ] and dendritic cells [ 84 ]. IL-6 production is also increased in primary human airway epithelial cells exposed to e-liquids, and this inflammatory response is amplified by nicotine [ 85 ].…”

Section: E-cigarettes and The Immune Responsementioning

confidence: 99%

Cardiorespiratory and Immunologic Effects of Electronic Cigarettes

Keith

Bhatnagar

2021

Curr Addict Rep

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Purpose of Review Although e-cigarettes have become popular, especially among youth, the health effects associated with e-cigarette use remain unclear. This review discusses current evidence relating to the cardiovascular, pulmonary, and immunological effects of e-cigarettes. Recent Findings The use of e-cigarettes by healthy adults has been shown to increase blood pressure, heart rate, and arterial stiffness, as well as resistance to air flow in lungs. Inhalation of e-cigarette aerosol has been shown to elicit immune responses and increase the production of immunomodulatory cytokines in young tobacco-naïve individuals. In animal models, long-term exposure to e-cigarettes leads to marked changes in lung architecture, dysregulation of immune genes, and low-grade inflammation. Exposure to e-cigarette aerosols in mice has been shown to induce DNA damage, inhibit DNA repair, and promote carcinogenesis. Chronic exposure to e-cigarettes has also been reported to result in the accumulation of lipid-laden macrophages in the lung and dysregulation of lipid metabolism and transport in mice. Although, the genotoxic and inflammatory effects of e-cigarettes are milder than those of combustible cigarettes, some of the cardiorespiratory effects of the two insults are comparable. The toxicity of e-cigarettes has been variably linked to nicotine, as well as other e-cigarette constituents, operating conditions, and use patterns. Summary The use of e-cigarettes in humans is associated with significant adverse cardiorespiratory and immunological changes. Data from animal models and in vitro studies support the notion that long-term use of e-cigarettes may pose significant health risks.

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“…Monocyte-derived DCs were generated as described previously with minor modifications (Chen et al, 2020). Briefly, human peripheral blood mononuclear cells were isolated from fresh venous blood taken from healthy blood donors using Histopaque-1077 (Sigma-Aldrich, USA) by density gradient centrifugation.…”

Section: Generation Of Human Monocyte-derived Dcsmentioning

confidence: 99%

Tumour-Derived Reg3A Educates Dendritic Cells to Promote Pancreatic Cancer Progression

Guo

Liao

et al. 2021

Molecules and Cells

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As a pancreatic inflammatory marker, regenerating isletderived protein 3A (Reg3A) plays a key role in inflammationassociated pancreatic carcinogenesis by promoting cell proliferation, inhibiting apoptosis, and regulating cancer cell migration and invasion. This study aimed to reveal a novel immuno-regulatory mechanism by which Reg3A modulates tumour-promoting responses during pancreatic cancer (PC) progression. In an in vitro Transwell system that allowed the direct co-culture of human peripheral blood-derived dendritic cells (DCs) and Reg3A-overexpressing/ silenced human PC cells, PC cell-derived Reg3A was found to downregulate CD80, CD83 and CD86 expression on educated DCs, increase DC endocytic function, inhibit DC-induced T lymphocyte proliferation, reduce IL-12p70 production, and enhance IL-23 production by DCs. The positive effect of tumourderived Reg3A-educated human DCs on PC progression was demonstrated in vivo by intraperitoneally transferring them into PC-implanted severe combined immunodeficiency (SCID) mice reconstituted with human T cells. A Reg3A-JAK2/STAT3 positive feedback loop was identified in DCs educated with Reg3A. In conclusion, as a tumour-derived factor, Reg3A acted to block the differentiation and maturation of the most important antigen-presenting cells, DCs, causing them to limit their potential anti-tumour responses, thus facilitating PC escape and progression.

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Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells

Cited by 15 publications

References 65 publications

Complicações pulmonares e extrapulmonares associadas ao uso de cigarros eletrônicos: uma revisão integrativa

Complicações pulmonares e extrapulmonares associadas ao uso de cigarros eletrônicos: uma revisão integrativa

Cardiorespiratory and Immunologic Effects of Electronic Cigarettes

Tumour-Derived Reg3A Educates Dendritic Cells to Promote Pancreatic Cancer Progression

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