Electron spin resonance dosimetry of teeth of Goiânia radiation accident victims

Rossi, Alexandre M.; Wafcheck, C.C.; Jesus, E.F. de; Pelegrini, F.

doi:10.1016/s0969-8043(00)00087-7

Cited by 26 publications

(8 citation statements)

References 14 publications

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“…Current methods to identify exposed individuals rely on the acute radiation syndrome (ARS) treatment guidelines (2) [which is often complicated with combined injuries such as burns and infections (3, 4)], on lymphocyte depletion and the total number of dicentric chromosomes (5). Electron spin resonance dosimetry of teeth has also been utilized providing results comparable to cytogenetics (6). Critical treatment of radiation-exposed individuals may sometimes be delayed due to lack of clinicians’ sufficiently trained to identify radiation victims and the complication of psychological trauma that can manifest in psychosomatic symptoms similar to ARS (7), leading to false identification of victims.…”

Section: Introductionmentioning

confidence: 99%

Development of a Metabolomic Radiation Signature in Urine from Patients Undergoing Total Body Irradiation

et al. 2014

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The emergence of the threat of radiological terrorism and other radiological incidents has led to the need for development of fast, accurate and noninvasive methods for detection of radiation exposure. The purpose of this study was to extend radiation metabolomic biomarker discovery to humans, as previous studies have focused on mice. Urine was collected from patients undergoing total body irradiation at Memorial Sloan-Kettering Cancer Center prior to hematopoietic stem cell transplantation at 4–6 h postirradiation (a single dose of 1.25 Gy) and 24 h (three fractions of 1.25 Gy each). Global metabolomic profiling was obtained through analysis with ultra performance liquid chromatography coupled to time-of-flight mass spectrometry (TOFMS). Prior to further analyses, each sample was normalized to its respective creatinine level. Statistical analysis was conducted by the nonparametric Kolmogorov-Smirnov test and the Fisher’s exact test and markers were validated against pure standards. Seven markers showed distinct differences between pre- and post-exposure samples. Of those, trimethyl-l-lysine and the carnitine conjugates acetylcarnitine, decanoylcarnitine and octanoylcarnitine play an important role in the transportation of fatty acids across mitochondria for subsequent fatty acid β-oxidation. The remaining metabolites, hypoxanthine, xanthine and uric acid are the final products of the purine catabolism pathway, and high levels of excretion have been associated with increased oxidative stress and radiation induced DNA damage. Further analysis revealed sex differences in the patterns of excretion of the markers, demonstrating that generation of a sex-specific metabolomic signature will be informative and can provide a quick and reliable assessment of individuals in a radiological scenario. This is the first radiation metabolomics study in human urine laying the foundation for the use of metabolomics in biodosimetry and providing confidence in biomarker identification based on the overlap between animal models and humans.

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Section: Introductionmentioning

confidence: 99%

Development of a Metabolomic Radiation Signature in Urine from Patients Undergoing Total Body Irradiation

et al. 2014

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“…Perhaps as a result of this, there have been very few examples of emergency dosimetry using the EPR from tooth enamel ex-vivo using the general procedures as described above to separate the RIS. Rossi et al (2000) applied EPR dosimetry to teeth from five victims of the Goiânia, Brazil, accident, evaluating doses that ranged from approximately 1 Gy to >16 Gy. Clairand et al (2008) determined doses from radiation accidents in Dakar and Abidjan by taking biopsies of enamel from the molars of three patients involved in accidental exposure to 192Ir, and these indicated exposures of several Gy to the teeth and jaws.…”

Section: Use In Dosimetrymentioning

confidence: 99%

Retrospective and emergency dosimetry in response to radiological incidents and nuclear mass-casualty events: A review

Bailiff

Sholom

McKeever

2016

Radiation Measurements

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Additional information:Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. HIGHLIGHTSReview of the use of luminescence and electron paramagnetic resonance in retrospective and emergency dosimetry.Optically stimulated luminescence (OSL), thermoluminescence (TL) and Electron Paramagnetic Resonance (EPR) results on biological and physical materials.Descriptions of use in emergency and retrospective dosimetry, following large-scale radiological events.http://www.sciencedirect.com/science/article/pii/S1350448716302359 ABSTRACTThis paper reviews recent research on the application of the physical dosimetry techniques of electron paramagnetic resonance (EPR) and luminescence (optically stimulated luminescence, OSL, and thermoluminescence, TL) to determine radiation dose following catastrophic, large-scale radiological events. Such data are used in dose reconstruction to obtain estimates of dose due to the exposure to external sources of radiation, primarily gamma radiation, by individual members of the public and by populations. The EPR and luminescence techniques have been applied to a wide range of radiological studies, including nuclear bomb detonation (e.g., Hiroshima and Nagasaki) nuclear power plant accidents (e.g., Chernobyl), radioactive pollution (e.g., Mayak plutonium facility), and in the future could include terrorist events involving the dispersal of radioactive materials. In this review we examine the application of these techniques in 'emergency' and 'retrospective' modes of operation that are conducted on two distinct timescales. For emergency dosimetry immediate action to evaluate dose to individuals following radiation exposure is required to assess deterministic biological effects and to enable rapid medical triage. Retrospective dosimetry, on the other hand, contributes to the reconstruction of doses to populations and individuals following external exposure, and contributes to the long-term study of stochastic processes and the consequential epidemiological effects. Although internal exposure, via ingestion of radionuclides for example, can be a potentially significant contributor to dose, this review is confined to those dose components arising from exposure to external radiation, which in most studies is gamma radiation.The nascent emergency dosimetry measurement techniques aim to perform direct dose evaluations for individuals who, as members of the public, are most unlikely to be carrying a dosimeter issued for radiation monitoring purposes in the event of a radiation incident. Hence attention has focused on b...

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“…The radiationinduced inorganic signals for egg shell under investigation exist in other irradiated bones and tooth enamels and have been assigned to lattice defects in the inorganic matrix of bone and tooth enamel i.e. in hydroxyapatite microcrystals (Raffi et al, 1989;Scherbina and Brik, 2000;Rossi et al, 2000). The ESR investigations of carbonated hydroxyapatite (Callens et al, 1987(Callens et al, , 1998Moens et al, 1991Moens et al, , 1994Moens et al, , 1996 have shown that the radiation-induced signal is composite, i.e., it consists of contributions from several paramagnetic species differing in location (hydroxyl(A-site), phosphate (B-site) or surface site location) and molecular structure (CO À 3 ; CO 3À 3 ; CO À 2 ; O À ; O À 3 ).…”

Section: Article In Pressmentioning

confidence: 99%

The use of ESR spectroscopy for the investigation of dosimetric properties of egg shells

Engin

Demirtaş

2004

Radiation Physics and Chemistry

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Electron spin resonance dosimetry of teeth of Goiânia radiation accident victims

Cited by 26 publications

References 14 publications

Development of a Metabolomic Radiation Signature in Urine from Patients Undergoing Total Body Irradiation

Development of a Metabolomic Radiation Signature in Urine from Patients Undergoing Total Body Irradiation

Retrospective and emergency dosimetry in response to radiological incidents and nuclear mass-casualty events: A review

The use of ESR spectroscopy for the investigation of dosimetric properties of egg shells

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