Electron microscopy of murine SJL/J disease

Abstract

In 1963 Murphy found that the inbred mouse strain SJL/J had a high incidence (up to 91%) of reticulum cell neoplasms at a mean age of 13 months (Murphy, 1963). The basic histological pattern of the neoplasms was that of type B according to Dunn's classification of mouse neoplasms (Dunn, 1954). Later, Murphy, (1964-65) described the tumors as " multicellular reticulum cell neoplasms " and stressed their close microscopic resemblance to Hodgkin's disease in humans. The susceptibility of SJL/J mice to spontaneous development of reticulum cell neoplasms of type B, as well as to the induction of lymphatic leukemia and myeloid leukemia by different leukemogenic agents, was studied more recently by Haran-Ghera et al. (1967). The pathogenesis of spontaneous reticulum cell sarcoma in SJL/J mice was described by Siegler and Rich (1968) who found that the neoplasm arose in the mesenteric lymph nodes and Peyer's patches.

Endocrine Disorders as a Contributory Factor to Neoplasia in SJL/J Mice2

“…Since it resembles Hodgkin's disease in humans, it is sometimes called Hodgkin's-like disease of mice. Descriptions of this disease in SJLj J and other strains of mice have been detailed in (1)(2)(3)(4)(5)(6)(7). Study of this neoplastic process in the SJLj J strain is especially compelling, inasmuch as reticulum cell neoplasms, contrary to lymphoma and lymphosarcoma, are generally rare in young mice and found only sporadically in old animals (8).…”