Electron microscope investigation of poly(ethylene oxide) supermolecular particles in solution

Cuniberti, C.; Ferrando, R.

doi:10.1016/0032-3861(72)90058-4

Cited by 18 publications

(7 citation statements)

References 14 publications

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“…From these results, one can confirm that clusters were effectively formed in PEG solution. In fact, the aggregation of PEG chains in their solutions has been previously reported, ,, and exact the same term cluster was also referred to . Very similar results of cluster size and their dependence on concentration were obtained for PEG of different M n (Figure S15).…”

Section: Resultssupporting

confidence: 78%

“…Among diverse techniques to judge whether the emission of an NTIP polymer follows CTE mechanism, the most straight and reliable support may be the detection of the presence of any polymer clusters, either by dynamic light scattering (DLS) or TEM. ,,,,,,, PEG aqueous solutions of different concentration were therefore subjected to DLS test. The results of P8k, given in Figure as an example, shows that PEG solution was not a veritable solution in the common vision, clusters or aggregates were present because particles were effectively detected, of which the size was increasing with concentration.…”

Section: Resultsmentioning

confidence: 99%

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Fluorescence Behavior and Mechanisms of Poly(ethylene glycol) and Their Applications in Fe³⁺ and Cr⁶⁺ Detections, Data Encryption, and Cell Imaging

Sun

Jiang

et al. 2021

ACS Sustainable Chem. Eng.

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In contrast to conventional fluorescent polymers featured by large conjugation structures, a new class of fluorescent polymers without any conjugations is gaining great interest in immerging applications beyond the possibility to achieve by the conjugated polymers. Poly(ethylene glycol) (PEG), widely used in biomedical fields for a long time owing to its nontoxicity and nonimmunogenicity, is found to be fluorescence emissive in the solid state and in aqueous solution, though deemed as not fluorescent in numerous reports. Through systematic study under different conditions, the emission is ascribed to the cluster formation of its chains; thereby the blue-shift of the emission with the excitation wavelength was interpreted through the Forster resonance energy transfer. The clusterization was ascertained through size measurements, Fourier transform infrared spectroscopy, NMR analyses, and the dependence on temperature, pH, and nonsolvent presence. Tested in the presence of competitive metal ions, selective emission quenching by Fe 3+ and Cr 6+ was observed. PEG was used as a sensor for the detection of Cr 6+ , Fe 3+ , and H 2 O 2 , outperforming most of the reported sensors alike. Its uses for data encryption and cell imaging were also presented. This work provides therefore a novel face of PEG with great potential in a variety of emerging applications, in particular, as sensors in the biomedical area.

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Section: Resultssupporting

confidence: 78%

Section: Resultsmentioning

confidence: 99%

Fluorescence Behavior and Mechanisms of Poly(ethylene glycol) and Their Applications in Fe³⁺ and Cr⁶⁺ Detections, Data Encryption, and Cell Imaging

Sun

Jiang

et al. 2021

ACS Sustainable Chem. Eng.

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“…The silk and PEO phase separate to produce PEO aggregates within the bulk aqueous silk phase [36, 43]. PEO aggregation within macromolecule solutions has been previously described [44]. The silk films were then dried and water-annealed by incubation within a water saturated vacuum environment to induce increased β-sheet formation that produces water insoluble films [16, 20].…”

Section: Resultsmentioning

confidence: 99%

Silk film biomaterials for cornea tissue engineering

Lawrence¹,

Marchant²,

Pindrus³

et al. 2009

Biomaterials

374

328

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Biomaterials for corneal tissue engineering must demonstrate several critical features for potential utility in vivo, including transparency, mechanical integrity, biocompatibility and slow biodegradation. Silk film biomaterials were designed and characterized to meet these functional requirements. Silk protein films were used in a biomimetic approach to replicate corneal stromal tissue architecture. The films were 2 μm thick to emulate corneal collagen lamellae dimensions, and were surface patterned to guide cell alignment. To enhance trans-lamellar diffusion of nutrients and to promote cell-cell interaction, pores with 0.5 to 5.0 μm diameters were introduced into the silk films. Human and rabbit corneal fibroblast proliferation, alignment and corneal extracellular matrix expression on these films in both 2D and 3D cultures was demonstrated. The mechanical properties, optical clarity and surface patterned features of these films, combined with their ability to support corneal cell functions suggest this new biomaterial system offers important potential benefits for corneal tissue regeneration.

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“…In the DMF/water solvent mixture, DMF is considered to be a good solvent for PPO and less good for PEO, i.e., PEO is not readily dissolved in DMF without slight heating. 36,37 Water, on the other hand, is a nonsolvent for PPO and a good solvent for PEO. 20 Therefore, when P123 is dissolved in DMF it may form clusters.…”

Section: Resultsmentioning

confidence: 99%

Complex morphologies of self-assembled block copolymer micelles in binary solvent mixtures: the role of solvent–solvent correlations

et al. 2011

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The morphologies and sizes of micellar aggregates, composed of the tri-block copolymer P123 (EO 20 PO 70 EO 20 ) in a mixture of the aprotic solvent N,N-dimethylformamide (DMF) and water, were investigated by combining Dynamic Light Scattering (DLS) and Cryogenic Transmission Electron Microscopy (cryo-TEM) experiments. At water concentrations between about 27 and 35 wt% bicontinuous micelles with distinct patterns were formed, in coexistence with very long, non-branched, worm-like micelles. Water concentration affects both the size and the morphology of the micellar aggregates. A careful study of the pure binary solvent mixture revealed the presence of dynamic solvent domains of nanometric size, even in the absence of copolymer. Strikingly, the size of these solvent nanodomains closely matched the size of the bicontinuous micelles in a polymer solution for the same water/ DMF ratios. We discuss these findings in terms of spinodal decomposition of the polymer solution, in which two-solvent domains contain solvent quality fluctuations that could determine the decomposition. In addition, we suggest another ''soft confinement'' mechanism that could be responsible for the formation of bicontinuous micelles. The local excess of one of the solvent species in the nano-domains could entrap a metastable morphology.

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Electron microscope investigation of poly(ethylene oxide) supermolecular particles in solution

Cited by 18 publications

References 14 publications

Fluorescence Behavior and Mechanisms of Poly(ethylene glycol) and Their Applications in Fe³⁺ and Cr⁶⁺ Detections, Data Encryption, and Cell Imaging

Fluorescence Behavior and Mechanisms of Poly(ethylene glycol) and Their Applications in Fe³⁺ and Cr⁶⁺ Detections, Data Encryption, and Cell Imaging

Silk film biomaterials for cornea tissue engineering

Complex morphologies of self-assembled block copolymer micelles in binary solvent mixtures: the role of solvent–solvent correlations

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Electron microscope investigation of poly(ethylene oxide) supermolecular particles in solution

Cited by 18 publications

References 14 publications

Fluorescence Behavior and Mechanisms of Poly(ethylene glycol) and Their Applications in Fe3+ and Cr6+ Detections, Data Encryption, and Cell Imaging

Fluorescence Behavior and Mechanisms of Poly(ethylene glycol) and Their Applications in Fe3+ and Cr6+ Detections, Data Encryption, and Cell Imaging

Silk film biomaterials for cornea tissue engineering

Complex morphologies of self-assembled block copolymer micelles in binary solvent mixtures: the role of solvent–solvent correlations

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Product

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Fluorescence Behavior and Mechanisms of Poly(ethylene glycol) and Their Applications in Fe³⁺ and Cr⁶⁺ Detections, Data Encryption, and Cell Imaging

Fluorescence Behavior and Mechanisms of Poly(ethylene glycol) and Their Applications in Fe³⁺ and Cr⁶⁺ Detections, Data Encryption, and Cell Imaging