Electron Emission of Phytohormone Genistein. Pathway for Communication

Getoff, N.; Schittl, Heike; Quint, Ruth

doi:10.2174/157340709789054740

Cited by 9 publications

(12 citation statements)

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“…1 and 2 for both peaks (A) and (B). This effect was also previously observed for other investigated hormones [11][12][13][14][15]. It was attributed to several factors: (i) formation of hormone associates (unstable complexes) in the solvent mixture, where the substrate molecules in ground state consume a part of the ejected .…”

Section: Resultssupporting

confidence: 76%

“…This effect was also observed in the case of other hormones [13,14]. Hence, for the sake of completeness, the electron ejection of 4-OHE 1 was verified at 45 °C.…”

Section: Resultssupporting

confidence: 71%

“…The same biological property has also been established for genistein [13] and adrenaline [14]. This capability of the hormones to act as electron mediator enables them to communicate with other biological systems [15].…”

Section: Introductionmentioning

confidence: 71%

“…In the frame of the previous studies [11][12][13][14][15] it was stated that the above mentioned hormones (17β-E2, PRG, TES, etc.) can eject electrons from their excited singlet states.…”

Section: Resultsmentioning

confidence: 99%

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The 4-hydroxyestrone: Electron emission, formation of secondary metabolites and mechanisms of carcinogenesis

Getoff

Gerschpacher

Hartmann

et al. 2010

Journal of Photochemistry and Photobiology B: Biology

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Abstract4-Hydroxyestrone (4-OHE 1 ), a typical cancer-inducing metabolite, originating from 17β-estradiol (17β-E2), was chosen as a model for the studies. The aim was to get a deeper insight in the mechanisms of its ability to initiate cancer. It was found, that 4-OHE 1 can eject electrons , when excited in the singlet state by monochromatic UV-light (γ = 254 nm) in polar media (water:ethanol = 40:60 vol.%). The quantum yield , determined for various 4-OHE 1 concentrations, is found to be as high as that previously observed for 17β-E2. It decreases with increasing substrate concentration, but it is enhanced at higher temperature. The ability of 4-OHE 1 to eject as well as to consume and to transfer electrons to other biological systems, classifies it as an electron mediator, similar to 17β-E2.The 4-OHE 1 transients resulting of the electron emission process are leading to the formation of secondary metabolites. Surprisingly, it was established that the secondary metabolites possess likewise the ability to eject as well as to consume electrons. Hence, they behave similar like 17β-E2. However, the structure of the secondary formed metabolites, which determinates their biological properties and carcinogenity, depends on the nature of the available reaction partners involved in their formation. A probable reaction mechanism explaining the subject matter is discussed.

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Section: Resultssupporting

confidence: 76%

“…This effect was also observed in the case of other hormones [13,14]. Hence, for the sake of completeness, the electron ejection of 4-OHE 1 was verified at 45 °C.…”

Section: Resultssupporting

confidence: 71%

Section: Introductionmentioning

confidence: 71%

“…In the frame of the previous studies [11][12][13][14][15] it was stated that the above mentioned hormones (17β-E2, PRG, TES, etc.) can eject electrons from their excited singlet states.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

The 4-hydroxyestrone: Electron emission, formation of secondary metabolites and mechanisms of carcinogenesis

Getoff

Gerschpacher

Hartmann

et al. 2010

Journal of Photochemistry and Photobiology B: Biology

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“…The same capability was also observed for other hormones like the phytohormone genistein [3], 4-hydroxyestrone (4-OHE1) [4], adrenaline (ADR) [5], etc. Thereby, a part of the ejected electrons are consumed by the hormones themselves with the reaction rate constant of k(e aq The transients resulting of the electron ejection process of the sexual hormones may interact with substances that are present in the actual media and form certain metabolites.…”

Section: Introductionsupporting

confidence: 55%

Electron emission and product analysis of estrone: progesterone interactions studied by experimentsin vitro

Gerschpacher

Getoff

Hartmann

et al. 2010

Gynecological Endocrinology

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Recent studies showed that hormones like progesterone, testosterone, etc. can eject e aq − (solvated electrons). By means of electron transfer processes via the brain, the hormones communicate with other biological systems in the organism. The present study proves that also estrone is able to emit electrons. Their yield strongly depends on the concentration of the hormone, temperature and on the absorbed energy. The metabolites resulting from this process are likewise able to generate electrons, however with much smaller yields. The formation of the estrone metabolites is studied by HPLC-analyses. In vitro experiments with MCF-7 cells demonstrate the distinct effect of progesterone on the carcinogenity of estrone metabolites. Probable reaction mechanisms for explanation of the observed effects are postulated.

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UV-radiation-induced electron emission by hormones. Hypothesis for specific communication mechanisms

Getoff

2009

Radiation Physics and Chemistry

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Electron Emission of Phytohormone Genistein. Pathway for Communication

Cited by 9 publications

References 0 publications

The 4-hydroxyestrone: Electron emission, formation of secondary metabolites and mechanisms of carcinogenesis

The 4-hydroxyestrone: Electron emission, formation of secondary metabolites and mechanisms of carcinogenesis

Electron emission and product analysis of estrone: progesterone interactions studied by experimentsin vitro

UV-radiation-induced electron emission by hormones. Hypothesis for specific communication mechanisms

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