Electron emission from photo-excited testosterone in water–ethanol solution

Getoff, N.; Schittl, Heike; Hartmann, Johannes; Quint, Ruth

doi:10.1016/j.jphotobiol.2008.11.009

Cited by 10 publications

(14 citation statements)

References 19 publications

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“…1 and 2 for both peaks (A) and (B). This effect was also previously observed for other investigated hormones [11][12][13][14][15]. It was attributed to several factors: (i) formation of hormone associates (unstable complexes) in the solvent mixture, where the substrate molecules in ground state consume a part of the ejected .…”

Section: Resultssupporting

confidence: 76%

“…The M1-metabolite is on the strength of its molecular structure able to eject likewise electrons, similarly to other biological substances [12,21,22]. The observed electron emission characterized by peak (B) in Figs.…”

Section: Resultsmentioning

confidence: 91%

“…In the frame of the previous studies [11][12][13][14][15] it was stated that the above mentioned hormones (17β-E2, PRG, TES, etc.) can eject electrons from their excited singlet states.…”

Section: Resultsmentioning

confidence: 99%

“…In this respect it should be mentioned that 17β-E2 as well as progesterone (PRG) [11] and testosterone (TES) [12] can emit as well as consume "solvated electrons"…”

Section: Introductionmentioning

confidence: 99%

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The 4-hydroxyestrone: Electron emission, formation of secondary metabolites and mechanisms of carcinogenesis

Getoff

Gerschpacher

Hartmann

et al. 2010

Journal of Photochemistry and Photobiology B: Biology

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Abstract4-Hydroxyestrone (4-OHE 1 ), a typical cancer-inducing metabolite, originating from 17β-estradiol (17β-E2), was chosen as a model for the studies. The aim was to get a deeper insight in the mechanisms of its ability to initiate cancer. It was found, that 4-OHE 1 can eject electrons , when excited in the singlet state by monochromatic UV-light (γ = 254 nm) in polar media (water:ethanol = 40:60 vol.%). The quantum yield , determined for various 4-OHE 1 concentrations, is found to be as high as that previously observed for 17β-E2. It decreases with increasing substrate concentration, but it is enhanced at higher temperature. The ability of 4-OHE 1 to eject as well as to consume and to transfer electrons to other biological systems, classifies it as an electron mediator, similar to 17β-E2.The 4-OHE 1 transients resulting of the electron emission process are leading to the formation of secondary metabolites. Surprisingly, it was established that the secondary metabolites possess likewise the ability to eject as well as to consume electrons. Hence, they behave similar like 17β-E2. However, the structure of the secondary formed metabolites, which determinates their biological properties and carcinogenity, depends on the nature of the available reaction partners involved in their formation. A probable reaction mechanism explaining the subject matter is discussed.

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Section: Resultssupporting

confidence: 76%

Section: Resultsmentioning

confidence: 91%

“…In the frame of the previous studies [11][12][13][14][15] it was stated that the above mentioned hormones (17β-E2, PRG, TES, etc.) can eject electrons from their excited singlet states.…”

Section: Resultsmentioning

confidence: 99%

“…In this respect it should be mentioned that 17β-E2 as well as progesterone (PRG) [11] and testosterone (TES) [12] can emit as well as consume "solvated electrons"…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The 4-hydroxyestrone: Electron emission, formation of secondary metabolites and mechanisms of carcinogenesis

Getoff

Gerschpacher

Hartmann

et al. 2010

Journal of Photochemistry and Photobiology B: Biology

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“…In recent studies, it was established that sexual hormones like 17β-estradiol (17β-E2), progesterone (PRG) [1] and testosterone (TES) [2] are able to emit electrons ('solvated electrons', e aq − ) from their excited singlet state. The same capability was also observed for other hormones like the phytohormone genistein [3], 4-hydroxyestrone (4-OHE1) [4], adrenaline (ADR) [5], etc.…”

Section: Introductionmentioning

confidence: 99%

Electron emission and product analysis of estrone: progesterone interactions studied by experimentsin vitro

Gerschpacher

Getoff

Hartmann

et al. 2010

Gynecological Endocrinology

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Recent studies showed that hormones like progesterone, testosterone, etc. can eject e aq − (solvated electrons). By means of electron transfer processes via the brain, the hormones communicate with other biological systems in the organism. The present study proves that also estrone is able to emit electrons. Their yield strongly depends on the concentration of the hormone, temperature and on the absorbed energy. The metabolites resulting from this process are likewise able to generate electrons, however with much smaller yields. The formation of the estrone metabolites is studied by HPLC-analyses. In vitro experiments with MCF-7 cells demonstrate the distinct effect of progesterone on the carcinogenity of estrone metabolites. Probable reaction mechanisms for explanation of the observed effects are postulated.

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