Electron-capture determination of metoclopramdie in biological fluids using fused silica capillary columns

Riggs, K. Wayne; Axelson, James E.; Rurak, D. W.; Hasman, D.A.; McErlane, B; Bylsma-Howell, M.; Mcmorland, G. H.; Ongley, R. C.; Price, J. D. E.

doi:10.1016/s0378-4347(00)85098-7

Journal of Chromatography B: Biomedical Sciences and Applicatio

1983

DOI: 10.1016/s0378-4347(00)85098-7

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Electron-capture determination of metoclopramdie in biological fluids using fused silica capillary columns

K. Wayne Riggs¹,

James E. Axelson²,

D. W. Rurak³

et al.

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Cited by 20 publications

(2 citation statements)

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“…3) Oral MCP may also be used to prevent nausea and vomiting caused by other medications. Moreover, MCP may be used in the fields of surgery, gynecology, cardiology and radiology.Due to their wide administration, considerable work has been done for determination of DAP and MCP include HPLC, 4-7) electron capture gas chromatography [8][9][10] and GC-MS 11) but involve an expensive experimental setup. Official methods for the determination of these drugs are usually based on extraction of the drug as a free base and its subsequent determination by UV-spectrophotometry.…”

mentioning

confidence: 99%

“…Due to their wide administration, considerable work has been done for determination of DAP and MCP include HPLC, [4][5][6][7] electron capture gas chromatography [8][9][10] and GC-MS 11) but involve an expensive experimental setup. Official methods for the determination of these drugs are usually based on extraction of the drug as a free base and its subsequent determination by UV-spectrophotometry.…”

mentioning

confidence: 99%

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Individual and Simultaneous Spectrophotometric Determination of Dapsone and Metoclopramide HCl in Pharmaceutical Dosage Forms and Synthetic Binary Mixtures

Omran

2005

Chem. Pharm. Bull.

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Dapsone (DAP), 4,4Ј-diaminodiphenyl sulfone, is used to treat leprosy and other skin conditions. 2) It may also be used to prevent malaria, for certain types of arthritis or other inflammatory conditions and pneumocystis carinii pneumonia (PCP). Metoclopramide hydrochloride (MCP), chemically, 4-amino-5-chloro-[2-(diethylamino)ethyl]-2-methoxybenzamide HCl is used to relieve certain stomach and esophagus problems such as diabetic gastroparesis and gastroesophageal reflux disorder (GERD). 3) Oral MCP may also be used to prevent nausea and vomiting caused by other medications. Moreover, MCP may be used in the fields of surgery, gynecology, cardiology and radiology.Due to their wide administration, considerable work has been done for determination of DAP and MCP include HPLC, 4-7) electron capture gas chromatography [8][9][10] and GC-MS 11) but involve an expensive experimental setup. Official methods for the determination of these drugs are usually based on extraction of the drug as a free base and its subsequent determination by UV-spectrophotometry. 12,13) Thus these methods suffer from strongly interferences of drug excipients and diluents. Spectrophotometric determination of these drugs has been proposed based on diazotization, [14][15][16][17] ion pair complexes, 18) charge transfer complexes, 19,20) and the formation of coloured Schiffs base upon interaction with dimethylaminocinnamaldehyde 21) and use of 9-chloroacridine 22) and sodium 1,2-naphthoquinone-4-sulfonic 23) as chromogenic reagents. These methods involve a time-consuming extraction procedures or heating and require strictly controlled reaction conditions. Many of these methods are less sensitive.For routine quality control, development of a simple, rapid and sensitive spectrophotometric method is highly desirable. In this paper, the employment of benzoylacetone as a new coupling agent for simple, rapid, accurate, precise and an inexpensive method for determination of DAP and MCP in bulk and pharmaceutical preparations is described. Furthermore, a simple first derivative spectrophotometric procedure has been applied to the simultaneous determination of DAP and MCP in synthetic binary mixture and pharmaceutical preparations without prior separation. ExperimentalApparatus A double-beam UV/Vis spectrophotometer (Perkin Elmer, lambda 3B) interfaced to IBM compatible computer with the capability of derivative mode operation was used. The spectra were recorded in 1-cm matched quartz cells. Suitable settings for recording the first-derivative spectra were: scan speed, 120 nm/min; response time, 2 s; spectral slit width, 2 nm; Dl, 1 nm; the ordinate minimum and maximum were Ϯ0.2 for the determination of DAP and MCP. The derivative spectra were obtained by numerical calculation with the aid of PECSS program using Savitzky-Golay algorithm. 24) Measurement of pH was carried out with a Janco electronics LTD digital pH-meter with a combined glass Calomel electrode.Reagents and Chemicals All chemicals were of analytical-reagent grade. Benzoylacetone (BAC, 2ϫ10 Ϫ...

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confidence: 99%

mentioning

confidence: 99%

Individual and Simultaneous Spectrophotometric Determination of Dapsone and Metoclopramide HCl in Pharmaceutical Dosage Forms and Synthetic Binary Mixtures

Omran

2005

Chem. Pharm. Bull.

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Liquid chromatographic analysis of metoclopramide with fluorescence detection in cirrhotic patients

Albani

Riva

Contin

et al. 1987

Biomedical Chromatography

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High Performance Liquid Chromatography for the Determination of Metoclopramide in Pharmaceutical Preparations Using Pre‐column Derivatization with Fluorescamine

Ulu

2012

Chin. J. Chem.

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A simple, rapid and sensitive high performance liquid chromatography (HPLC) method was developed for the determination of metoclopramide in pharmaceutical preparation. The method is based on the derivatization of metoclopramide with fluorescamine. The separation was achieved on a C18 column using methanol‐water (70:30, V/V) mobile phase. Fluorescence detector was used at the excitation and emission of 403 and 485 nm, respectively. The method was validated for linearity, limit of detection, limit of quantification, precision, accuracy, recovery, robustness and system suitability. The assay was linear over the concentration range of 100–2000 ng/mL. The mean recovery was 100.37%. The proposed method was successfully applied to the assay of metoclopramide in tablet preparation. The preparation was also analyzed with an official method and statistical comparison by t‐ and F‐tests revealed that there was no significant difference between the results of the two methods with respect to mean values and standard deviations at the 95% confidence level.

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Electron-capture determination of metoclopramdie in biological fluids using fused silica capillary columns

Cited by 20 publications

References 21 publications

Individual and Simultaneous Spectrophotometric Determination of Dapsone and Metoclopramide HCl in Pharmaceutical Dosage Forms and Synthetic Binary Mixtures

Individual and Simultaneous Spectrophotometric Determination of Dapsone and Metoclopramide HCl in Pharmaceutical Dosage Forms and Synthetic Binary Mixtures

Liquid chromatographic analysis of metoclopramide with fluorescence detection in cirrhotic patients

High Performance Liquid Chromatography for the Determination of Metoclopramide in Pharmaceutical Preparations Using Pre‐column Derivatization with Fluorescamine

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