Electron-Capture Capillary Gas Chromatographic Determination of Phenylpropanolamine in Human Plasma Following Derivatization with Trifluoroacetic Anhydride

Crisologo, N.; Dye, D.; Bayne, W.F.

doi:10.1002/jps.2600730936

Cited by 7 publications

(1 citation statement)

References 13 publications

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“…et al(18) for ACTA PRDIATR 81 (1992) Intravesical (A) and urethral (B) pressure recordings before (above) and 2 h after (below) oral administration of PPA (3 mg/kg, plasma level 181 nglml). Each point indicates a wave of hyperactivity ( > 10 cmH2O > 10 s.).…”

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confidence: 99%

Effect of phenylpropanolamine on incontinence in children with neurogenic bladders. A double‐blind crossover study

Åmark

Beck

1992

Acta Paediatrica

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In children with myelodysplasia and a low-level spinal cord lesion (low lumbar-sacral), detrusor hyperactivity together with dyssynergic urethral function forms the main pathophysiological basis for incontinence. Pharmacological treatment of incontinence due to neurogenic bladder dysfunction has been tried, mainly with anticholinergics and alpha-adrenoceptor antagonists. In this study, the effects of the alpha-adrenoceptor agonist phenylpropanolamine on urodynamic parameters and incontinence were investigated in 10 patients. Effects on incontinence were evaluated in a double-blind crossover trial. Plasma concentrations of phenylpropanolamine were measured by means of gas chromatography-mass spectrometry. Phenylpropanolamine reduced detrusor hyperactivity and improved continence, but the effect was not so pronounced as to make the patients continent.

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confidence: 99%

Effect of phenylpropanolamine on incontinence in children with neurogenic bladders. A double‐blind crossover study

Åmark

Beck

1992

Acta Paediatrica

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Noradrenergic Agents

Rangan¹

2012

Medical Toxicology of Drug Abuse

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Enantiomeric analysis of phenylpropanolamine in plasma via resolution of dinitrophenylurea derivatives on a high performance liquid chromatographic chiral stationary phase

Doyle¹,

Brunner²,

Vick³

1991

Biomedical Chromatography

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Racemic phenylpropanolamine was resolved on a high performance liquid chromatographic (HPLC) chiral stationary phase (CSP) as the 3,5-dinitrophenyl ureide derivative. The CSP was prepared by a simple in situ procedure in which (R)-(1-naphthyl)ethyl isocyanate was bound to aminopropyl silanized silica through a urea linkage. The enantiomeric ureides were prepared by a room-temperature, 60-second procedure, accomplishing simultaneous extraction and derivatization and utilizing achiral 3,5-dinitrophenyl isocyanate as reagent. Baseline resolution was readily achieved under normal phase conditions, with a separation factor (alpha) of 1.16 and a resolution factor (RS) of 2.2. Elution was complete within 10 min. A limit of detection, by UV at 235 nm, of 250 pg per isomer was established. Feasibility of the procedure for plasma determinations was demonstrated by assay of samples from a canine subject.

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Electron-Capture Capillary Gas Chromatographic Determination of Phenylpropanolamine in Human Plasma Following Derivatization with Trifluoroacetic Anhydride

Cited by 7 publications

References 13 publications

Effect of phenylpropanolamine on incontinence in children with neurogenic bladders. A double‐blind crossover study

Effect of phenylpropanolamine on incontinence in children with neurogenic bladders. A double‐blind crossover study

Noradrenergic Agents

Enantiomeric analysis of phenylpropanolamine in plasma via resolution of dinitrophenylurea derivatives on a high performance liquid chromatographic chiral stationary phase

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