Electromembrane extraction of gonadotropin‐releasing hormone agonists from plasma and wastewater samples

Nojavan, Saeed; Bidarmanesh, Tina; Mohammadi, Ali; Yaripour, Saeid

doi:10.1002/elps.201500555

Cited by 39 publications

(14 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The examples of the former group are (i) capillary liquid–liquid electroextraction based on a fast electromigration of polar analytes from organic phase to aqueous phase and on formation of a narrow zone in this phase and (ii) electro‐driven extraction of angiotensin II antipeptide across supported liquid membrane . Both these approaches can be used for a fast preconcentration of peptides prior to their CE and LC analyses .…”

Section: Sample Preparationmentioning

confidence: 99%

Recent developments in capillary and microchip electroseparations of peptides (2015–mid 2017)

Kašička

2017

Electrophoresis

View full text Add to dashboard Cite

The review brings a comprehensive overview of recent developments and applications of high performance capillary and microchip electroseparation methods (zone electrophoresis, isotachophoresis, isoelectric focusing, affinity electrophoresis, electrokinetic chromatography, and electrochromatography) to analysis, microscale isolation, purification, and physicochemical and biochemical characterization of peptides in the years 2015, 2016, and ca. up to the middle of 2017. Advances in the investigation of electromigration properties of peptides and in the methodology of their analysis (sample preseparation, preconcentration and derivatization, adsorption suppression and EOF control, and detection) are described. New developments in particular CE and CEC methods are presented and several types of their applications to peptide analysis are reported: qualitative and quantitative analysis, determination in complex (bio)matrices, monitoring of chemical and enzymatical reactions and physical changes, amino acid, sequence and chiral analysis, and peptide mapping of proteins. Some micropreparative peptide separations are shown and capabilities of CE and CEC methods to provide important physicochemical characteristics of peptides are demonstrated.

show abstract

Section: Sample Preparationmentioning

confidence: 99%

Recent developments in capillary and microchip electroseparations of peptides (2015–mid 2017)

Kašička

2017

Electrophoresis

View full text Add to dashboard Cite

show abstract

“…Given that the main driving force in EME procedure is the electrical potential, analytes should be in their ionic forms in solution. Both peptides, LA and TA, bear positive charge in pH values lower than 11.0 and the net positive charge increased as the pH decreases . In pH values lower than the optimum value of 4.5, diffusion of the peptide into the SLM was decreased due to the highly positively charged peptide.…”

Section: Resultsmentioning

confidence: 96%

“…In recent years, a growing interest has been focused on developing efficient EME technique for the determination of peptides in biological matrices and is still in its infancy. Simultaneous EME and determination of four gonadotropin‐releasing hormone agonists (leuprolide, triptorelin, buserelin, and alarelin) from the spiked human plasma and wastewater have been reported by Nojavan et al .…”

Section: Introductionmentioning

confidence: 94%

Quantification of controlled release leuprolide and triptorelin in rabbit plasma using electromembrane extraction coupled with HPLC–UV

2019

View full text Add to dashboard Cite

An electromembrane extraction followed by HPLC-UV technique was developed and validated for quantification of leuprolide and triptorelin in rabbit plasma. The influencing parameters on the extraction efficiency were optimized using experimental design methodology. The optimized conditions were found to be; supported liquid membrane: a mixture of 1-octanol and 2-ethyl hexanol (1:1) containing 10% v/v di(2-ethylhexyl) phosphate, applied voltage: 5 V, extraction time: 5 min, pH of the donor phase: 4.5 and pH of the acceptor phase: 1.0. The optimized method was validated for linearity, intraday and interday precision, and accuracy in rabbit plasma. The range of quantification for both peptides was 0.5-1000 ng/mL with regression coefficients higher than 0.994. Relative recoveries of leuprolide and triptorelin were found to be 80.3 and 75.5%, respectively. Limits of quantification and detection for both peptides were found to be 0.5 and 0.15 ng/mL, respectively. The validated method was successfully applied to pharmacokinetic study of the 1-month depot formulations of each peptide after subcutaneous administration to rabbits.

show abstract

“…Use of very low volumes of an organic solvent makes this method environmentally friendly (Gjelstad, Pedersen-Bjergaard, 2011;Marothu, Gorrepati, Vusa, 2013;Gjelstad, Pedersen-Bjergaard, 2013;Yamini, Seidi, Rezazadeh, 2014;Huang et al, 2015). EME-combined analytical methods have been recently used for determining and quantifying drugs, dyes, amino acids, peptides, heavy metals, and environmental pollutants from different sample matrices (Huang et al, 2015;Fotouhi et al, 2015;Yaripour et al, 2018;Asadi, Nojavan, 2016;Zahedi et al, 2016;Eibak et al, 2012;Nojavan et al, 2016;Kubáň et al, 2011;Villar-Navarro et al, 2016). Page 2 / 9 Phenobarbital (Figure 1) is an anticonvulsant drug which is useful in the treatment of partial seizures and generalized tonic-clonic seizures especially when attacks are difficult to control.…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of phenobarbital in biological fluids: Analyte enrichment by an electrically-assisted microextraction technique

Yaripour

Ebrahimi

Mohammadi

2020

Braz. J. Pharm. Sci.

Self Cite

View full text Add to dashboard Cite

An electrically-assisted microextraction method called electromembrane extraction, followed by a simple high performance liquid chromatography and ultraviolet detection was developed and validated for determining phenobarbital in biological samples. The major parameters influencing the electromembrane extraction procedure including solvent composition, voltage, pH of acceptor and donor solutions, salt effect, and time of extraction were evaluated and optimized. The drug was extracted from the donor aqueous sample solution (pH 9) to the acceptor aqueous solution (pH 13). The donor and acceptor phases were separated by a hollow fiber dipped in 1-octanol as a supported liquid membrane. A voltage of 40 V during 20 minutes was applied as the driving force. The enrichment factor was obtained >51 which enhanced the sensitivity of the instrument. Limit of detection and limit of quantitation were 7.5 and 25 ng/ mL, respectively. The method was linear over the range of 25-1000 ng/mL for phenobarbital (R 2 >0.9998) with repeatability (%RSD) between 0.4% and 6.8% (n = 3). The proposed method was successfully applied to human plasma and urine samples with relative recovery of 70-80% and %RSD < 6.8%.Zahedi P, Davarani SSH, Moazami HR, Nojavan S. Surfactant assisted pulsed two-phase electromembrane extraction followed by GC analysis for quantification of basic drugs in biological samples.

show abstract

Electromembrane extraction of gonadotropin‐releasing hormone agonists from plasma and wastewater samples

Cited by 39 publications

References 38 publications

Recent developments in capillary and microchip electroseparations of peptides (2015–mid 2017)

Recent developments in capillary and microchip electroseparations of peptides (2015–mid 2017)

Quantification of controlled release leuprolide and triptorelin in rabbit plasma using electromembrane extraction coupled with HPLC–UV

Quantitative analysis of phenobarbital in biological fluids: Analyte enrichment by an electrically-assisted microextraction technique

Contact Info

Product

Resources

About