Electromagnetic fields as first messenger in biological signaling: Application to calmodulin-dependent signaling in tissue repair

Pilla, Arthur A.; Fitzsimmons, Robert J.; Muehsam, David; Wu, June K.; Rohde, Christine; Casper, Diana

doi:10.1016/j.bbagen.2011.10.001

Cited by 74 publications

(73 citation statements)

References 62 publications

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“…23 The cellular effect of PEMF on calcium oscillation for modulating Calcium-Calmodulin-NO signaling is a basis for any response from vascular and neural cells to PEMF. 18,19,21,31,42 Many studies have revealed that electromagnetic fields at a wide range of frequencies, activate certain cellular mechanisms, increase blood flow, and produce vasodilation of the vascular tone. 20,43 These mechanisms may be related to cellular survival activity, the vascular system, as well as inflammation process following the use of PEMF.…”

Section: Discussionmentioning

confidence: 99%

“…The exposure of neural and vascular cells to electromagnetic fields that resonate at 10 Hz can induce intracellular calcium oscillations and change the signaling cascades such as calcium-calmodulin-NO. 18,19 Electromagnetic fields also enhance vascular tonicity and velocity. 20,21 They stimulate ATP, mitochondrial enzymes synthesis as well as the anti-inflammatory process.…”

Section: Introductionmentioning

confidence: 99%

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The efficiency of pulsed electromagnetic field in refractory migraine headaches: a randomized, single-blinded, placebo-controlled, parallel group

et al. 2016

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Background: The study attempts to investigate the effect of PEMF therapy on Refractory Migraines (RM), both those which were related and those which were not related to menstrual cycle, in a randomized, single blind, placebo-controlled study.Methods: The study attempts to investigate the effect of PEMF therapy on Refractory Migraines (RM), both those which were related and those which were not related to menstrual cycle, in a randomized, single blind, placebo-controlled study.Results: There was a significant improvement for the active group in terms of their headache days, durations and work-loss hours due to headache compared to the placebo group after 2 weeks. The added results of the assessment of the active group indicated a significant improvement in the days and duration of headaches, work-loss hours and number of medications even after a following 4-8-month period. Headache intensity and the amount of medication used for headache were reduced only in RM patients that had headaches which were not related to their menstrual cycles.Conclusions: PEMF (10 Hz, 4-5mT) can be considered as a beneficial and persistent prophylactic treatment option for refractory migraine.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The efficiency of pulsed electromagnetic field in refractory migraine headaches: a randomized, single-blinded, placebo-controlled, parallel group

et al. 2016

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“…[34] Subsequent studies have confirmed that exposure to EMF can induce excessive activity in voltage-gated calcium channels in different cell types. [35][36][37][38] Panagopoulos et al have proposed that EMF exert oscillating forces on free ions in the extracellular fluid which then facilitates transmembrane movement of calcium ions. [37] These researchers postulated that external oscillating forces could produce a forced vibration on each free ion, and when the amplitude of the ions' force-vibration transcends some critical value, the oscillating ions can give a false signal to electrically sensitive gated calcium channels which interrupts the electrochemical balance of the cell membranes.…”

Section: Emf and Initiation Of Pain: Proposed Mechanism At Cellular Lmentioning

confidence: 99%

“…[37] In a relatively recent study, Pilla et al reported an increase in intracellular calcium occurs almost immediately after EMF exposure which produces a calcium/calmodulin-dependent increase in less than 5 seconds. [38] The mobilisation of cellular calcium in response to external EMF signals or the interference of an EMF with calcium regulatory process is considered an essential target of EMF action and initiation of pain.…”

Section: Emf and Initiation Of Pain: Proposed Mechanism At Cellular Lmentioning

confidence: 99%

A Potential Role of Chronic Exposure to Extremely Low-Frequency Electromagnetic Fields in Triggering Persistent Pain Post Breast Cancer Surgery: A Review

Stark¹,

Kessmann²,

McCarter³

et al. 2017

Int J Surg Med

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Persistent Pain after Breast Cancer Surgery (PPBCS) ranks second to amputation of extremities for chronic neuropathic pain. PPBCS is associated with the formation of intercostobrachial neuroma bulbs along the lateral chest. These neuroma bulbs are either un-/thinly myelinated and express hypersensitivity to environmental stimuli. Hypersensitivity is manifested as spontaneous pain in response to innocuous stimuli and exaggerating pain in response to noxious stimuli. Excision of neuromas, a joint intervention to alleviate pain, has been reported as ineffective. Experience of individuals with amputation of extremities and experimental models of human nerve injuries confirm anthropogenic EMF evoke excruciating pain. Findings from in-vitro and animal studies support that EMF exposure depolarises cell membranes, interrupts voltage-gated calcium channels which then activates peripheral sensory neurons and initiates propagation of a train of action potentials along the axons of primary afferent nerve fibres. The World Health Organization guidelines, established based on an approximation of the human anatomy are limited and assumes no potential compounding effects of nerve injuries or alterations of the physiological milieu of tissues. The objective of this review is to direct the attention of the medical community to the potential role of anthropogenic EMF as a risk factor for persistent pain after breast surgery. Patients rely heavily on the recommendations of their providers to manage their pain. The current epidemic of opioid abuse in the US has been partially attributed to the high prescription rate of opioid-based painkillers. Understanding the potential triggers of chronic pain can reduce dependency on pharmaceutical agents.

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“…There are indications that non-ionizing radiation produces in biological systems effects that are not caused by temperature increase or nonthermal effects (the limits established by electromagnetic field [EMF] legislation refer only to thermal effects). [1][2][3] Exposure of an area of the human body to microwaves also exposes the tissues nearest the area to non-ionizing radiation. Since shoulder pain is frequently treated with diathermy in rehabilitation, the nearby thyroid gland would be repeatedly exposed to microwaves during this type of treatment.…”

Section: Introductionmentioning

confidence: 99%

Exposure to non-ionizing radiation provokes changes in rat thyroid morphology and expression of HSP-90

Misa-Agustiño

Jorge-Mora

Jorge-Barreiro

et al. 2015

Exp Biol Med (Maywood)

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Non-ionizing radiation at 2.45 GHz may modify the morphology and expression of genes that codify heat shock proteins (HSP) in the thyroid gland. Diathermy is the therapeutic application of non-ionizing radiation to humans for its beneficial effects in rheumatological and musculo-skeletal pain processes. We used a diathermy model on laboratory rats subjected to maximum exposure in the left front leg, in order to study the effects of radiation on the nearby thyroid tissue. Fifty-six rats were individually exposed once or repeatedly (10 times in two weeks) for 30 min to 2.45 GHz radiation in a commercial chamber at different non-thermal specific absorption rates (SARs), which were calculated using the finite difference time domain technique. We used immunohistochemistry methods to study the expression of HSP-90 and morphological changes in thyroid gland tissues. Ninety minutes after radiation with the highest SAR, the central and peripheral follicles presented increased size and the thickness of the peripheral septa had decreased. Twenty-four hours after radiation, only peripheral follicles radiated at 12 W were found to be smaller. Peripheral follicles increased in size with repeated exposure at 3 W power. Morphological changes in the thyroid tissue may indicate a glandular response to acute or repeated stress from radiation in the hypothalamic-pituitary-thyroid axis. Further research is needed to determine if the effect of this physical agent over time may cause disease in the human thyroid gland.

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Electromagnetic fields as first messenger in biological signaling: Application to calmodulin-dependent signaling in tissue repair

Cited by 74 publications

References 62 publications

The efficiency of pulsed electromagnetic field in refractory migraine headaches: a randomized, single-blinded, placebo-controlled, parallel group

The efficiency of pulsed electromagnetic field in refractory migraine headaches: a randomized, single-blinded, placebo-controlled, parallel group

A Potential Role of Chronic Exposure to Extremely Low-Frequency Electromagnetic Fields in Triggering Persistent Pain Post Breast Cancer Surgery: A Review

Exposure to non-ionizing radiation provokes changes in rat thyroid morphology and expression of HSP-90

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