Electrolyzed Hydrogen-Saturated Water for Drinking Use Elicits an Antioxidative Effect: A Feeding Test with Rats

Yanagihara, Tomoyuki; Arai, Kazuyoshi; Miyamae, Kazuhiro; Sato, Bunpei; Shudo, T; Yamada, Masaharu; Aoyama, Masahide

doi:10.1271/bbb.69.1985

Cited by 42 publications

(30 citation statements)

References 4 publications

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“…Taken together with previous studies, the hepatic oxidoreduction-related gene upregulation observed in this study appears to confirm the findings reported to date [1][2][3] concerning the antioxidant effect of Complex interdependencies between categories sharing differentially expressed genes were observed. The genes are represented as gene symbols.…”

supporting

confidence: 93%

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Hepatic Oxidoreduction-Related Genes Are Upregulated by Administration of Hydrogen-Saturated Drinking Water

Nakai

Sato²,

Ushiama

et al. 2011

Bioscience, Biotechnology, and Biochemistry

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confidence: 93%

“…1,2) Drinking molecular hydrogen-saturated water (hydrogen water) prevented atherosclerosis development in apolipoprotein E knockout mice, 3) but its effect on gene expression in normal animals is still unclear. To determine the effects of hydrogen water consumption on gene expression comprehensively, we conducted experiments using DNA microarray technology.…”

mentioning

confidence: 99%

Hepatic Oxidoreduction-Related Genes Are Upregulated by Administration of Hydrogen-Saturated Drinking Water

Nakai

Sato²,

Ushiama

et al. 2011

Bioscience, Biotechnology, and Biochemistry

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“…The mechanism of these researches has been partly explained by anti-oxidant effect of ERW and reduced oxidative stress. Recent increasing evidences suggest that ERW has an antioxidant effect by scavenging ROS or free radicals including superoxide anion radicals (O 2 − ·), hydrogen peroxide molecules (H 2 O 2 ), singlet oxygen ( 1 O 2 ) and hydroxyl radicals (·OH) (20,25). Moreover Hanaoka et al (6) reported that the enhancement of antioxidant effects of ERW was due to the increase of the ionic product of water (pK w ) as solvent, therefore enhancing…”

Section: Referencesmentioning

confidence: 99%

Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats

Park

Song

et al. 2009

Biomed. Res.

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Ethanol consumption disturbs the balance between the pro-and anti-oxidant systems of the organism, leading to oxidative stress. Electrolyzed-reduced water (ERW) is widely used by people in East Asia for drinking purposes because of its therapeutic properties including scavenging effect of reactive oxygen species. This study was performed to investigate the effect of ERW on acute ethanol-induced hangovers in Sprague-Dawley rats. Alcohol concentration in serum of ERWtreated rats showed significant difference at 1 h, 3 h and 5 h respectively as compared with the rats treated with distilled water. Both alcohol dehydrogenase type 1 and acetaldehyde dehydrogenase related with oxidation of alcohol were significantly increased in liver tissue while the level of aspartate aminotransferase and alanine aminotransferase in serum was markedly decreased 24 h after pre-oral administration of ERW. Moreover, oral administration of ERW significantly activated non-ezymatic (glutathione) and enzymatic (glutathione peroxidase, glutathione-S-transferase, Cu/Zn-superoxide dismutase and catalase) antioxidants in liver tissues compared with the control group. These results suggest that drinking ERW has an effect of alcohol detoxification by antioxidant mechanism and has potentiality for relief of ethanol-induced hangover symptoms.

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“…We have recently reported that molecular hydrogen (H 2 ) reduces oxidative stress Fukuda et al, 2007), and can penetrate the blood-brain barrier to protect neurons by gaseous diffusion; however, inhalation of hydrogen gas may be unsuitable as continuous hydrogen consumption for preventive use. A brief report has suggested that consumption of water containing hydrogen at a saturated level (hydrogen water) reduces oxidative stress in rats, as shown by decreased levels of urine oxidized guanine and hepatic lipid peroxide (Yanagihara et al, 2005). Thus, we examined the effect of hydrogen water on cognitive decline induced by oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice

Nagata

Nakashima-Kamimura

Mikami

et al. 2008

Neuropsychopharmacol

227

182

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We have reported that hydrogen (H 2 ) acts as an efficient antioxidant by gaseous rapid diffusion. When water saturated with hydrogen (hydrogen water) was placed into the stomach of a rat, hydrogen was detected at several mM level in blood. Because hydrogen gas is unsuitable for continuous consumption, we investigated using mice whether drinking hydrogen water ad libitum, instead of inhaling hydrogen gas, prevents cognitive impairment by reducing oxidative stress. Chronic physical restraint stress to mice enhanced levels of oxidative stress markers, malondialdehyde and 4-hydroxy-2-nonenal, in the brain, and impaired learning and memory, as judged by three different methods: passive avoidance learning, object recognition task, and the Morris water maze. Consumption of hydrogen water ad libitum throughout the whole period suppressed the increase in the oxidative stress markers and prevented cognitive impairment, as judged by all three methods, whereas hydrogen water did not improve cognitive ability when no stress was provided. Neural proliferation in the dentate gyrus of the hippocampus was suppressed by restraint stress, as observed by 5-bromo-2 0 -deoxyuridine incorporation and Ki-67 immunostaining, proliferation markers. The consumption of hydrogen water ameliorated the reduced proliferation although the mechanistic link between the hydrogen-dependent changes in neurogenesis and cognitive impairments remains unclear. Thus, continuous consumption of hydrogen water reduces oxidative stress in the brain, and prevents the stress-induced decline in learning and memory caused by chronic physical restraint. Hydrogen water may be applicable for preventive use in cognitive or other neuronal disorders.

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Electrolyzed Hydrogen-Saturated Water for Drinking Use Elicits an Antioxidative Effect: A Feeding Test with Rats

Cited by 42 publications

References 4 publications

Hepatic Oxidoreduction-Related Genes Are Upregulated by Administration of Hydrogen-Saturated Drinking Water

Hepatic Oxidoreduction-Related Genes Are Upregulated by Administration of Hydrogen-Saturated Drinking Water

Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats

Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice

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