Electrolytic deposition of octacalcium phosphate/collagen composite coating on titanium alloy

Abstract

Osteointegration of titanium or its alloy with bone can be greatly improved by calcium phosphate coatings, and further enhanced by an extracellular matrix protein layer such as collagen. In this study, an octacalcium phosphate (OCP)/collagen composite coating layer on Ti6Al4V substrate was prepared using electrolytic deposition method. A layer of OCP mineral consisting of flake-like crystals was first formed on the Ti6Al4V substrate. Subsequently, mineralized collagen fibrils were deposited on the former OCP layer. These collagen fibrils were interconnected and well adhered on the OCP layer so that they were immobilized. The microstructure of the composite coating varied with collagen concentration in the electrolyte. This study could offer a possibility of fabricating a desired surface matrix on orthopedic implants to enhance bone formation and fixation of implants.

Characteristics and cyto-compatibility of Collagen/Ca–P coatings on Ti6Al4V substrate

“…The electrochemical process is a feasible method for synthesizing Ca-P/ collagen composite coatings. However, owing to the difference in density between Ca-P and collagen fibril, the composite coating is not homogenous on a substrate [13]. In the study of Chen et al, [14] the classical biomimetic process was used by immersing substrates in a collagen-containing simulated body fluid with 5 times inorganic ionic concentration (5-SBF) for about 24 h to allow co-precipitation.…”

Novel biodegradable calcium phosphate/polymer composite coating with adjustable mechanical properties formed by hydrothermal process for corrosion protection of magnesium substrate

“…However, the main issue for pure Ca‐P coatings is their brittleness, potentially leading to early failure of the bone–implant interface. Use of composite coatings can be an ideal approach to overcome this issue, and they can be formed by a combination of Ca‐P as inorganic part and bioresorbable polymers as organic component . In addition, human bone is a composite of Ca‐P and collagen.…”

“…In addition, human bone is a composite of Ca‐P and collagen. From the viewpoint of bionics, if the composition and structure of implant are similar to the human bone, it will be favorable for cells to adhere and proliferate to form bone tissue . Zhang et al worked on hydroxyapatite (HA)/stearic acid composite coating by using the combination of electrodeposition and solution method.…”

In VivoEctopic Bone Formation by Devitalized Mineralized Stem Cell Carriers Produced Under Mineralizing Culture Condition

“…This matrix is produced by osteoblastic cells through specific physiological events, 18,19 giving rise to a unique biological architecture and mineralization hierarchy 20,21 that governs its functionality and osteoinductivity. 22 Introducing all these biomimetic features in a controlled way through synthetic processing routes (such as biomimetic deposition in simulated body fluid, 23,24 electrolytic deposition, 25,26 plasma spraying, 27,28 and sol-gel 29,30 techniques) remains challenging, mainly due to the lack of in-depth knowledge on the biological events and the limitations of existing technological tools. 31–33 Recently, we have reported the feasibility to use either Ca 2+ or PO 4 3− supplementation to produce living 3D osteogenic hybrids in vitro.…”