Electrolyte imbalance in infectious disease patients at King Abdulaziz Hospital, Jeddah

Albeladi, Fatma; Salem, Iman Mohmad Wahby; Albandar, Albandari Abdullah; Almusaylim, Hamidah Abdullah; Albabdar, Ali Sameer

doi:10.1016/j.jtumed.2021.09.010

Cited by 2 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also observed a significant relationship between the mean concentration of chlorine between surviving and non-surviving patients (p = 0.026), indicating that chlorine could be an extremely sensitive biological indicator of SARS-CoV-2 and that reduction could be predictive of bad outcomes. Albeladi et al, also noted that there was a significant decrease in serum chloride values at admission, although during hospitalization the levels increased significantly [34]. In agreement with our results, Petnak et al showed that serum chloride at hospital discharge in the range of 100-108 mmol/L predicted a favorable clinical outcome [38], which was similar to the mean chlorine concentration of 102 ± 1.03 mmol/L observed among survived patients (Table 2).…”

Section: Discussionsupporting

confidence: 91%

“…Generally neglected, variations in sodium concentration could be an indicator of disease severity and have been linked to late hospitalization and significant morbidity [33]. Our results were similar to a study carried out by Albeladi et al observed low concentrations of sodium in severely COVID-19 patients on admission [34]. A recent study carried out by Chen et al in China showed that the SARS-CoV-2 infection has a strong association with a decrease in potassium, which was not consistent with the results of this study [35].…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Clinical Features Related to Severity and Mortality among COVID-19 Patients in a Pre-Vaccine Period in Luanda, Angola

et al. 2022

View full text Add to dashboard Cite

Background: Infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with clinical features of diverse severity. Few studies investigated the severity and mortality predictors of coronavirus disease 2019 (COVID-19) in Africa. Herein, we investigated the clinical features of severity and mortality among COVID-19 patients in Luanda, Angola. Methods: This multicenter cohort study involved 101 COVID-19 patients, between December 2020 and April 2021, with clinical and laboratory data collected. Analysis was done using independent-sample T-tests and Chi-square tests. The results were deemed significant when p < 0.05. Results: The mean age of patients was 51 years (ranging from 18 to 80 years) and 60.4% were male. Fever (46%), cough (47%), gastrointestinal symptoms (26.7%), and asthenia (26.7%), were the most common symptoms. About 64.4% of the patients presented coexistent disorders, including hypertension (42%), diabetes (17%), and chronic renal diseases (6%). About 23% were non-severe, 77% were severe, and 10% died during hospitalization. Variations in the concentration of neutrophil, urea, creatinine, c-reactive protein, sodium, creatine kinase, and chloride were independently associated with severity and/or mortality (p < 0.05). Conclusion: Several factors contributed to the severity and mortality among COVID-19 patients in Angola. Further studies related to clinical features should be carried out to help clinical decision-making and follow-up of COVID-19 patients in Angola.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Clinical Features Related to Severity and Mortality among COVID-19 Patients in a Pre-Vaccine Period in Luanda, Angola

et al. 2022

View full text Add to dashboard Cite

show abstract

“…From Saudi Arabia, a study showed the prevalence of hypokalemia during hospitalization (17.2%) increased as compared to the time of admission in patients with infectious diseases. 15 In the Netherlands, there was an 8.4% (100/1178) incidence of hypokalemia in a general hospital population.…”

Section: Discussionmentioning

confidence: 99%

Incidence, risk factors, and prognosis of hypokalemia in patients with normokalemia at hospital admission.

Viswanathan

Bhargav

2023

Preprint

View full text Add to dashboard Cite

Background Hypokalemia (K+<3.5 mmol/L) is a common electrolyte abnormality observed in 20% of hospitalized patients. Previous studies have often dealt with the symptoms of hypokalemia, its prevalence, and risk factors in hospitalized patients. Very few studies have dealt with hospital-induced hypokalemia. The aim of this study was to find the incidence, predisposing risk factors, and prognosis of patients developing hypokalemia in patients with normokalemia at admission. Materials and methods A prospective observational study was performed over a period of two months. Patients with at least two potassium values after admission and normal K values at admission were considered for inclusion. Clinical features, diagnoses, laboratory reports, and treatment details, including antibiotics, were noted. Incidence of hypokalemia was determined. Patients with and without hypokalemia were compared. Results A total of 653 patients were studied; 138 (21.1%) developed hypokalemia. Diabetes, ischemic heart disease, heart failure, chronic kidney disease, hypertension, chronic liver disease, and COPD were the most associated comorbidities. Urea, creatinine, transaminases, and neutrophilia at admission differed significantly between those with and without hypokalemia groups. Most patients developed mild hypokalemia (78.2%); moderate and severe hypokalemia developed in 19.5% and 2% of patients, respectively. Hypokalemia developed mostly on the second(22.4%) and third (24.6%) day of hospitalization. Antibiotics were used in 60% of patients, with 23% and 24.5% receiving one and two antibiotics, respectively. Only linezolid and metronidazole use were significant with regard to the patient’s second potassium value. The potassium values returned to normal within 2.5±1.9 days. Three patients subsequently developed hyperkalemia. Conclusion Patients admitted under General Medicine mostly developed mild hypokalemia, even if they had multiple risk factors for developing hypokalemia. Inpatient hypokalemia had an incidence of 21%. An overwhelming majority (~88%) had at least one risk factor. Hypokalemia was not attributed to causing mortality in any patient.

show abstract

Electrolyte imbalance in infectious disease patients at King Abdulaziz Hospital, Jeddah

Cited by 2 publications

References 29 publications

Clinical Features Related to Severity and Mortality among COVID-19 Patients in a Pre-Vaccine Period in Luanda, Angola

Clinical Features Related to Severity and Mortality among COVID-19 Patients in a Pre-Vaccine Period in Luanda, Angola

Incidence, risk factors, and prognosis of hypokalemia in patients with normokalemia at hospital admission.

Contact Info

Product

Resources

About