Clinical Features Related to Severity and Mortality among COVID-19 Patients in a Pre-Vaccine Period in Luanda, Angola

Sebastião, Cruz S.; Cogle, Adis Pérez; Teixeira, Alice; Cândido, Ana Micolo; Tchoni, Chissengo; Amorim, Maria João; Loureiro, N’gueza; Parimbelli, Paolo; Penha‐Gonçalves, Carlos; Demengeot, Jocelyne; Sacomboio, Euclides Nenga Manuel; Mendes, Manuela; Arrais, Margarete; Morais, Joana; Vasconcelos, Jocelyne Neto de; Brito, Miguel

doi:10.3390/tropicalmed7110338

Cited by 4 publications

(5 citation statements)

References 42 publications

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“…Previous studies have documented higher rates of STIs and other communicable diseases in Luanda, partly due to the high concentration of risk groups such as sex workers and injecting drug users. [28][29][30][31][32][33] Likewise, studies carried out in Ethiopia and Pakistan also showed that the majority of blood donation candidates with positive serology came from urbanized regions. [34,35] Although not statistically signi cant (p > 0.05), more than 95% of STI and 100% of multiple infections were observed in unmarried subjects, indicating that this group may serve as a potential source of STI dissemination (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence and risk factors of STIs among rejected blood donors at the National Blood Transfusion Service in Angola

Sebastião,

Jandondo,

Vigário

et al. 2023

Preprint

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Background Sexually transmitted infections (STIs) are a global health concern. Blood donation centres employ comprehensive screening measures to identify donors with STIs, including HIV, HBV, HCV, and syphilis ensuring the safety of the donated blood and protecting the recipients. Herein, we investigated the seroprevalence of STIs and risk factors related to multiple infections among rejected blood donors at the National Blood Transfusion Service (NBTS) in Angola. Methods This was a cross-sectional study conducted with 1668 rejected blood donors serologically screened for anti-HBsAg, anti-HCV, anti-HIV, and anti-TP at the NBTS, located in Luanda, the capital city of Angola, between March 2022 to July 2023. Results Overall, HIV (11.2%), HBsAg (71.7%), HCV (9.30%), and Syphilis (8.80%) were detected. The multiple infection rate was 2.30%, from these, HIV/HBV (1.10%), HIV/HCV (0.60%), HIV/Syphilis (1.20%), HBV/HCV (8.0%), HBV/Syphilis (5.50%), and HCV/Syphilis (1.80%) coinfections, were detected. HIV and syphilis were related to age groups (p < 0.05). HBV was related to age group, areas of residence, occupation, and Rh factor (p < 0.05). HCV was related to areas of residence and educational level (p < 0.05). No relationship was observed between demographic characteristics with multiple infections (p > 0.05). Individuals aged over 40 years (OR: 2.48, p = 0.393), males (OR: 1.33, p = 0.639), non-urbanized regions (OR: 1.18, p = 0.594), low educational level (OR: 3.46, p = 0.222), and employed (OR: 1.34, p = 0.423), presented a higher likelihood of having multiple infections. Conclusions Our results demonstrate a high rate of circulation of STIs among young blood donation candidates in Luanda. However, the prevalence, particularly that of HBV, is one of the highest in the sub-Saharan African region, suggesting that priority should be given to strengthening donor screening and considering the possibility of including nucleic acid-based screening techniques.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence and risk factors of STIs among rejected blood donors at the National Blood Transfusion Service in Angola

Sebastião,

Jandondo,

Vigário

et al. 2023

Preprint

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“…However, Africa accounted for only 12.8 M cases and 259,000 reported deaths 1 . These reports were likely vastly underestimated as significant excess mortalities were reported throughout Africa 2,3 . A high estimated incidence of asymptomatic infections and limited testing in many regions 4 support the notion that many case numbers remain undocumented 5 .…”

Section: Introductionmentioning

confidence: 99%

Insights into SARS‐CoV‐2 in Angola during the COVID‐19 peak: Molecular epidemiology and genome surveillance

Francisco,

van Wyk,

Moir

et al. 2023

Influenza Resp Viruses

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BackgroundIn Angola, COVID‐19 cases have been reported in all provinces, resulting in >105,000 cases and >1900 deaths. However, no detailed genomic surveillance into the introduction and spread of the SARS‐CoV‐2 virus has been conducted in Angola. We aimed to investigate the emergence and epidemic progression during the peak of the COVID‐19 pandemic in Angola.MethodsWe generated 1210 whole‐genome SARS‐CoV‐2 sequences, contributing West African data to the global context, that were phylogenetically compared against global strains. Virus movement events were inferred using ancestral state reconstruction.ResultsThe epidemic in Angola was marked by four distinct waves of infection, dominated by 12 virus lineages, including VOCs, VOIs, and the VUM C.16, which was unique to South‐Western Africa and circulated for an extended period within the region. Virus exchanges occurred between Angola and its neighboring countries, and strong links with Brazil and Portugal reflected the historical and cultural ties shared between these countries. The first case likely originated from southern Africa.ConclusionA lack of a robust genome surveillance network and strong dependence on out‐of‐country sequencing limit real‐time data generation to achieve timely disease outbreak responses, which remains of the utmost importance to mitigate future disease outbreaks in Angola.

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“…3 To understand the impact of COVID-19 in Angola, some studies reported putative factors related to morbidity, severity, and mortality due to COVID-19, including age over 40 years, symptoms such as cough, fever, gastrointestinal symptoms, and asthenia, as well as comorbidities such as hypertension, diabetes mellitus, and chronic kidney disease. 4 Since there are few studies conducted in African countries, we proposed to study clinical characteristics and variables associated with COVID-19 in a tertiary-level hospital in Luanda, the capital city of Angola, during the first year of the COVID-19 pandemic.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and variables associated with COVID-19 morbidity and mortality in Luanda, Angola, in the first year of the pandemic

Margarete LT,

Welwitschia A F,

Maura P A

et al. 2023

Afr H. Sci.

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Background: The impact of SARS-CoV-2 infection in Africa is still unclear. In comparison to Europe and North America, morbidity and death rates are lower. Several factors have been proposed, including geographical variation in virus impact, environmental factors, differences in age distribution, and the impact of infectious diseases such as malaria, HIV infection and tuberculosis.Objectives: We investigated the clinical characteristics and putative determinants linked with COVID-19 in Angolan patients.Methods: Cross-sectional study undertaken at Military Hospital, Luanda, from March 2020 to March 2021. The survey collected sociodemographic and clinical information.Results: The sample included 1,683 patients aged ≥18 years, 64% men, with mean age of 46.3 years. SARS-CoV-2 was positive in 39% of the cases with RT-PCR. Patients ≥46 years with a level of education of ≥12 years had a considerably higher likelihood of testing positive. About 58% of positive patients had at least one comorbidity, of which hypertension and Diabetes were associated with SARS-CoV-2 infection. HIV and pulmonary TB were putative protective factors. About 14% of positive patients died. Most deaths occurred in patients ≥46 years, with less education and unemployed. Working as a healthcare practitioner was linked to a protective effect. Malignant diseases were the most common comorbidities associated with death.Conclusions: We identified putative factors related to SARS-CoV-2 infection and mortality. HIV and TB were protective and not associated with mortality. Further study with a broader scope should be conducted to explain the main features related to COVID-19 mortality in Angola.

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Clinical Features Related to Severity and Mortality among COVID-19 Patients in a Pre-Vaccine Period in Luanda, Angola

Cited by 4 publications

References 42 publications

Seroprevalence and risk factors of STIs among rejected blood donors at the National Blood Transfusion Service in Angola

Seroprevalence and risk factors of STIs among rejected blood donors at the National Blood Transfusion Service in Angola

Insights into SARS‐CoV‐2 in Angola during the COVID‐19 peak: Molecular epidemiology and genome surveillance

Clinical characteristics and variables associated with COVID-19 morbidity and mortality in Luanda, Angola, in the first year of the pandemic

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