Electrolyte Changes in Human Striated Muscle in Acidosis and Alkalosis

Studies of Alkalosis. Ii. Electrolyte Abnormalities in Alkalosis Resulting From Pyloric Obstruction 1

“…The observations reported here are in keeping with clinical observations and with direct measurements of intracellular composition in alkalosis in which potassium deficiency has been demonstrated (2,3,4,17).…”

“…Hypopotassemia has also been clearly demonstrated during. acidosis (4). The measurements merely confirm the observations of others that hypopotassemia is a fairly regular occurrence in this syndrome (4,17).…”

“…More recently, in addition to extracellular water and electrolyte deficits, intracellular deficits of potassium-and partial replacement of these deficits by sodiumhave been demonstrated in experimentally induced alkalosis (2, 3), and in patients with alkalosis from vomiting (4). This report describes abnormalities of water and electrolyte metabolism, and discusses some mechanisms of their production, in patients with alkalosis resulting primarily from loss of upper gastrointestinal contents.…”

Studies on the Intracellular Water, Sodium and Potassium in Thyrotoxic Myopathy and in Thyrotoxic Periodic Paralysis

“…Sodium and potassium in human skeletal muscle tissue have been reported by many authors (Mudge and Vislocky, 1949;Baldwin et al, 1952;Mokotoff et al, 1952;Talso et al, 1953;Wilson, 1955;Barnes et al, 1957;Litchfield and Gaddie, 1958;Nichols, 1958;Flear and Crampton, 1960;Bergstrom, 1962) and the results showed some difference due to different method of ashing or preparation. Studies upon water and electrolytes metabolism in thyrotoxicosis have been done by several authors (Byrom 1934;Boekelman, 1948;Cachera et al, 1949;Munro et al, 1958;Staffurth, 1962), though none of the report concerning actual determination of intracellular water and electrolytes has been published.…”

“…Skeletal muscle tissue analysis of the human being in normal or pathological conditions were published by many authors (Mudge and Vislocky, 1949;Baldwin et al, 1952;Mokotoff et al, 1952;Talso et al, 1953;Wilson, 1955;Barnes et al, 1957;Litchfield and Gaddie, 1958;Nichols, 1958;Flear and Crampton, 1960;Bergstrom, 1962). In determining the distribution of ions within biopsied samples, chloride space was frequently to be a measure of the extracellular space.…”