Electrolyte and Plasma Responses After Pickle Juice, Mustard, and Deionized Water Ingestion in Dehydrated Humans

Miller, Kevin C.

doi:10.4085/1062-6050-48.6.21

Cited by 2 publications

(5 citation statements)

References 12 publications

(17 reference statements)

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Section: Other Etiological Factors In Eamcmentioning

confidence: 99%

“…Recently, an effort has been devoted to evaluate a method of using food extracts like peppers, ginger, mustard, and cinnamon to resolve EAMC [68]. Consuming these food extracts does not seem to affect plasma electrolyte concentrations [68]. Instead, it is thought that these food extracts can activate transient receptor potential channels (TRP channels) that are capable of disrupting hyper excited motor neurons [73].…”

Section: Other Etiological Factors In Eamcmentioning

confidence: 99%

“…This effect was, however, attributed to the fact that pickle juice contains acetic acid that can trigger a reflex, probably in the oropharyngeal region, that acts to increase inhibitory neurotransmitter activity in cramping muscles [67]. In fact, consuming pickle juice was found to be ineffective in raising plasma electrolyte concentrations in both hydrated and dehydrated humans [68,69]. Quinine is a medication used to treat malaria caused by mosquito bites, but also often prescribed to treat cramps of all causes.…”

Section: Preventionmentioning

confidence: 99%

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Exercise Associated Muscle Cramps - A Current Perspective

Qiu¹,

Kang²

2017

Arch Sports Med

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Exercise-associated muscle cramps (EAMC) are a common condition experienced by recreational and competitive athletes and often require medical attention during or immediately after sports events. Despite the high prevalence of this condition, the etiology of EAMC remains poorly understood, and there is a lack of high levels of evidence to guide the management of this condition. The previous claim as to how EAMC come about is being challenged by more recent evidence suggesting a distinctive mechanism. EAMC has been long attributed to an excessive sweat sodium loss together with dehydration. However, growing evidence suggests that EAMC occurs with sustained and repetitive muscle contraction that results in fatigue. The purpose of this article is to examine the existing scientific evidence in support of various views on the etiology of EAMC and to highlight the most current understanding of this complex condition. Various strategies adopted to treat and prevent EAMC also are discussed even though most of them remain anecdotal and have yet to be substantiated by research experimentation.

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Section: Other Etiological Factors In Eamcmentioning

confidence: 99%

Section: Other Etiological Factors In Eamcmentioning

confidence: 99%

Section: Preventionmentioning

confidence: 99%

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Exercise Associated Muscle Cramps - A Current Perspective

Qiu¹,

Kang²

2017

Arch Sports Med

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“…This effect was not immediate (~90 s) nor due to the electrolytes consumed since small volumes of pickle juice did not affect plasma volume, plasma electrolyte concentrations, or plasma osmolality. 44,45 Instead, the authors 44 hypothesized vinegar triggered an oropharyngeal reflex that inhibited cramping. Conversely only anecdotal evidence exists to mustards efficacy at relieving acute EAMC.…”

Section: Transient Receptor Potential (Trp) Receptor Agonistsmentioning

confidence: 99%

“…However, the efficacy of mustard is unlikely due to electrolyte replacement since ingesting large volumes (~135 g) had no impact on plasma electrolyte concentrations, plasma osmolality, or plasma volume up to 60 minutes post-ingestion. 45 Other studies investigated the effect of spicy, capsaicin-based TRP agonists on cramp susceptibility. While one study 42 reported longer times before cramping; higher contraction forces necessary to induce cramping; and lower muscle activity during cramping, all subjects still cramped postingestion of the TRP-agonist drink.…”

Section: Transient Receptor Potential (Trp) Receptor Agonistsmentioning

confidence: 99%

An Evidence-Based Review of the Pathophysiology, Treatment, and Prevention of Exercise-Associated Muscle Cramps

Miller

McDermott

Yeargin

et al. 2021

Journal of Athletic Training

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Exercise-associated muscle cramps (EAMC) are common and frustrating for athletes and the physically active. We critically-appraised the EAMC literature to provide evidence-based treatment and prevention recommendations. While the pathophysiology of EAMC appears controversial, recent evidence suggests EAMC are due to a confluence of unique intrinsic and extrinsic factors rather than a singular etiology. The treatment of acute EAMC continues to include self-application or clinician-guided gentle static stretching until EAMC abatement. Once the painful EAMC are alleviated, clinicians can continue treatment on the sidelines by focusing on patient-specific risk factors that the clinician believes may have contributed to the genesis of EAMC. For EAMC prevention, clinicians should first perform a thorough medical history followed by identification of the patients' unique risk factors that could have coalesced to elicit EAMC. Individualizing EAMC prevention strategies will likely be more effective than generalized advice (e.g., drink more fluids).

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Electrolyte and Plasma Responses After Pickle Juice, Mustard, and Deionized Water Ingestion in Dehydrated Humans

Cited by 2 publications

References 12 publications

Exercise Associated Muscle Cramps - A Current Perspective

Exercise Associated Muscle Cramps - A Current Perspective

An Evidence-Based Review of the Pathophysiology, Treatment, and Prevention of Exercise-Associated Muscle Cramps

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