Electrokinetic pumping and detection of low‐volume flows in nanochannels

Mela, P.; Tas, Niels Roelof; Berenschot, J.W.; Nieuwkasteele, Jan van; Berg, Albert van den

doi:10.1002/elps.200406083

Cited by 16 publications

(18 citation statements)

References 21 publications

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“…However, the PL underneath the cantilever will have a tapered profile as the SL is covering the PL during part of the SLE time [19]. This effect is shown in Fig.…”

Section: Tapered Gapmentioning

confidence: 99%

Tuning a racetrack ring resonator by an integrated dielectric MEMS cantilever

Abdulla¹,

Kauppinen²,

Dijkstra³

et al. 2011

Opt. Express

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Abstract:The principle, fabrication and characterization of a dielectric MEMS cantilever located a few 100 nm above a racetrack ring resonator are presented. After fabrication of the resonators on silicon-on-insulator (SOI) wafers in a foundry process, the cantilevers were integrated by surface micromachining techniques. Off-state deflections of the cantilevers have been optimized to appropriately position them near the evanescent field of the resonator. Using electrostatic actuation, moving the cantilevers into this evanescent field, the propagation properties of the ring waveguide are modulated. We demonstrate 122 pm tuning of the resonance wavelength of the optical ring resonator (in the optical C-band) without change of the optical quality factor, on application of 9 V to a 40 µm long cantilever. This compact integrated device can be used for tuning/switching a specific wavelength, with very little energy for operation and negligible cross talk with surrounding devices. ©2011 Optical Society of America

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“…However, the PL underneath the cantilever will have a tapered profile as the SL is covering the PL during part of the SLE time [19]. This effect is shown in Fig.…”

Section: Tapered Gapmentioning

confidence: 99%

Tuning a racetrack ring resonator by an integrated dielectric MEMS cantilever

Abdulla¹,

Kauppinen²,

Dijkstra³

et al. 2011

Opt. Express

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“…A number of methods have been exploited to manipulate fluid flow in microchannels,37 with pressure driven38 and electro‐osmotic flow39 being the most common, although alternative forces, such as acoustic streaming40 and thermocapillarity41 have also been demonstrated. The uniform velocity profile of electro‐osmotic flow (EOF) avoids many of the diffusion fluctuations that are present in pressure driven flow.…”

Section: Fluidics Of Imer Devicesmentioning

confidence: 99%

Fundamentals and applications of immobilized microfluidic enzymatic reactors

Matosevic

Szita

Baganz

2011

J of Chemical Tech & Biotech

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OVERVIEW: Over the last decade, the utility of immobilized microfluidic enzyme reactors (IMERs) has been demonstrated in a wide variety of fields, including medical diagnostics and therapy, biosensors, organic synthesis, drug discovery and many other applications. Of particular interest to the pharmaceutical industry is the potential for high throughput experimentation afforded by these systems, with a view to combinatorial synthesis for drug discovery applications. This article will focus on the current state of IMER systems, including immobilization techniques and microchannel flow generation, with a particular emphasis on applications and future prospects in view of likely directions and market potential of this field.IMPACT: The numerous advantages of attaching enzymes to a solid support, such as reuse of a single batch of enzyme, improved stability and durability, the ability to stop the reaction rapidly by removing the product from the reaction solution and the absence of enzyme contamination of the product are some of the attractive features of such systems. There are, however, a number of issues requiring careful consideration when developing such microsystems, including, but not limited to, surface modifications and exact control of fluid behaviour in microchannels, detection limitations, increased integration, and the reusability of the chips. APPLICATIONS: IMERs have received wide, including commercial, application as diagnostic tools for point-of-care applications, and, increasingly, as analytical tools in early drug development. Furthermore, peptide mapping and proteomics have employed IMER systems extensively over the past decade and growth in these areas continues.

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“…20,[26][27][28] Very long etching times associated with sacrificial methods result in a noticeable difference of exposure to the etchant along the channel. 29 The walls at the entrance of the channel are more exposed to the etching solution than in the middle. Even with the excellent etching selectivity conferred by the couple SiO 2 /Si 3 N 4 , a tapering (32 nm mm À1 of channel) of the structure has been measured.…”

Section: Surface Micromachiningmentioning

confidence: 99%