Electrokinetic and Biochemical Changes in Erythrocytes under the Action of Terahertz Range Electromagnetic Waves

Deryugina, А. V.; Oshevenskiy, L. V.; Таламанова, М. Н.; Цветков, А. И.; Glyavin, M. Yu.; Krylov, V. N.

doi:10.1134/s0006350917060033

Cited by 2 publications

(6 citation statements)

References 7 publications

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“…In Ref. 230 , RBCs were exposed to the CW THz radiation, with the frequency of 0.263 THz and the irradiance of 0.5 to

, for 1 and 15 min, and to the pulsed THz radiation, with the pulse repetition rate of 2.5 Hz, the pulse duration of 200 ms, and the average irradiance of 0.1 to

, for 1 min. As a result of the THz exposure, the intensity of lipid peroxidation (malondialdehyde concentration) in erythrocytes increased as compared with the nonirradiated control sample, whereas the observed effect depends on the exposure duration.…”

Section: Terahertz Exposure Of Biological Objects With Different Levels Of Organizationmentioning

confidence: 99%

“…Such effects may indicate both induction of the oxidative stress upon THz irradiation and activation of the response of the cell antioxidant systems. 230 Other parameters were also altered after such an exposure. The electrophoretic mobility of cells decreased after the CW THz exposure and, conversely, increased after the pulsed one, regardless of the irradiance value.…”

Section: Terahertz Exposure Of Biological Objects With Different Levels Of Organizationmentioning

confidence: 99%

“…In turn, the metabolic parameters, such as ATP and 2, 3 diphosphoglycerate concentrations, depended on both the exposure regime and irradiance. 230 …”

Section: Terahertz Exposure Of Biological Objects With Different Levels Of Organizationmentioning

confidence: 99%

“…In turn, the metabolic parameters, such as ATP and 2, 3 diphosphoglycerate concentrations, depended on both the exposure regime and irradiance. 230 In Ref. 231, safety limits of blood leukocytes exposure to THz waves were studied, using several pulsed THz emitters and the method of DNA comets.…”

Section: Blood Cellsmentioning

confidence: 99%

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Cellular effects of terahertz waves

et al. 2021

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. Significance: An increasing interest in the area of biological effects at exposure of tissues and cells to the terahertz (THz) radiation is driven by a rapid progress in THz biophotonics, observed during the past decades. Despite the attractiveness of THz technology for medical diagnosis and therapy, there is still quite limited knowledge about safe limits of THz exposure. Different modes of THz exposure of tissues and cells, including continuous-wave versus pulsed radiation, various powers, and number and duration of exposure cycles, ought to be systematically studied. Aim: We provide an overview of recent research results in the area of biological effects at exposure of tissues and cells to THz waves. Approach: We start with a brief overview of general features of the THz-wave–tissue interactions, as well as modern THz emitters, with an emphasis on those that are reliable for studying the biological effects of THz waves. Then, we consider three levels of biological system organization, at which the exposure effects are considered: (i) solutions of biological molecules; (ii) cultures of cells, individual cells, and cell structures; and (iii) entire organs or organisms; special attention is devoted to the cellular level. We distinguish thermal and nonthermal mechanisms of THz-wave–cell interactions and discuss a problem of adequate estimation of the THz biological effects’ specificity. The problem of experimental data reproducibility, caused by rareness of the THz experimental setups and an absence of unitary protocols, is also considered. Results: The summarized data demonstrate the current stage of the research activity and knowledge about the THz exposure on living objects. Conclusions: This review helps the biomedical optics community to summarize up-to-date knowledge in the area of cell exposure to THz radiation, and paves the ways for the development of THz safety standards and THz therapeutic applications.

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“…In Ref. 230 , RBCs were exposed to the CW THz radiation, with the frequency of 0.263 THz and the irradiance of 0.5 to

, for 1 and 15 min, and to the pulsed THz radiation, with the pulse repetition rate of 2.5 Hz, the pulse duration of 200 ms, and the average irradiance of 0.1 to

Section: Terahertz Exposure Of Biological Objects With Different Levels Of Organizationmentioning

confidence: 99%

Section: Terahertz Exposure Of Biological Objects With Different Levels Of Organizationmentioning

confidence: 99%

“…In turn, the metabolic parameters, such as ATP and 2, 3 diphosphoglycerate concentrations, depended on both the exposure regime and irradiance. 230 …”

Section: Terahertz Exposure Of Biological Objects With Different Levels Of Organizationmentioning

confidence: 99%

Section: Blood Cellsmentioning

confidence: 99%

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Cellular effects of terahertz waves

et al. 2021

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“… 25 In addition, H 2 is a conditionally inert substance with zero redox potential in aqueous solutions; it does not exhibit toxic properties even under prolonged exposure in the form of highly concentrated gas mixtures. 26 …”

Section: Introductionmentioning

confidence: 99%

Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study

et al. 2023

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Molecular hydrogen (H 2 ) has been considered a preventive and therapeutic medical gas in numerous diseases. The study aimed to investigate the potential role of molecular hydrogen as a component of anesthesia in surgical treatment with cardiopulmonary bypass (CPB) of acquired valve defects on the functional state of red blood cells (RBC) and functional indicators of cardiac activity. This clinical trial was conducted with 20 patients referring to the Specialized Cardiosurgical Clinical Hospital, Nizhny Novgorod, Russian Federation, who underwent elective surgery with CPB. Twenty-four patients were randomly assigned to two groups. First group included 12 patients (research group) who received H 2 at a concentration of 1.5–2.0% through a facemask using a breathing circuit of the ventilator together with anesthesia immediately after tracheal intubation and throughout the operation. Second group (control group) included 12 patients who were not given H 2 . Blood samples were withdrawn from peripheral veins and radial artery at four stages: immediately after the introduction of anesthesia (stage 1), before the start of CPB (stage 2), immediately after its termination (stage 3) and 24 hours after the operation (the early postoperative period) (stage 4). An increase in electrophoretic mobility, an increase in the metabolism of red blood cells, and a decrease in the aggregation of red blood cells relative to the corresponding indicators of the control group were observed in the research group. Patients in the research group had a decrease in oxidative stress manifestations most pronounced one day after the operation. There was a statistically significant difference between the indicators of myocardial contractile function in the research and control group on the 1 st and 3 rd days after surgery. H 2 inhalation leads to improvement of functional state of red blood cells, which is accompanied by a more favorable course of the early postoperative period. These data show the presence of protective properties of molecular hydrogen.

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Electrokinetic and Biochemical Changes in Erythrocytes under the Action of Terahertz Range Electromagnetic Waves

Cited by 2 publications

References 7 publications

Cellular effects of terahertz waves

Cellular effects of terahertz waves

Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study

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