Electrohydrodynamic atomization of quasi-monodisperse drug-loaded spherical/wrinkled microparticles

Hong, Youliang; Li, Yanyan; Yin, Yizi; Li, Dongmei; Zou, Guangtian

doi:10.1016/j.jaerosci.2008.02.004

Cited by 87 publications

(52 citation statements)

References 44 publications

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“…Initially, the electrospraying parameters chosen in this work were based on previous studies on optimization of electrosprayed particles [15,[26][27][28][29][30]33,36,37]. Temperature and relative humidity ranged from 22 to 24 °C, and 44 to 49% respectively.…”

Section: Microsphere Productionmentioning

confidence: 99%

“…In the context of drug loading, the bioactive molecule is mixed to the polymer solution before electrospraying and can further be emulsified [21]. Some studies which have been undertaken include encapsulation of hydrophilic and hydrophobic model drugs [12], model proteins [21][22][23][24][25], antibiotics [14,26] and anti-cancer drugs [13] in polylactide (PLA) [12,21], poly(lactic-co-glycolic acid) (PLGA) [24,26], polycaprolactone (PCL) [13,24] and chitosan [14].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have correlated the effects of key variables of electrospraying [26][27][28][29][30]. Most of these studies are PLGA-based, which are well-known as the most common biodegradable and FDA-approved polymers in tissue engineering literature.…”

Section: Introductionmentioning

confidence: 99%

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Electrospraying, a Reproducible Method for Production of Polymeric Microspheres for Biomedical Applications

2011

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Abstract:The ability to reproducibly load bioactive molecules into polymeric microspheres is a challenge. Traditional microsphere fabrication methods typically provide inhomogeneous release profiles and suffer from lack of batch to batch reproducibility, hindering their potential to up-scale and their translation to the clinic. This deficit in homogeneity is in part attributed to broad size distributions and variability in the morphology of particles. It is thus desirable to control morphology and size of non-loaded particles in the first instance, in preparation for obtaining desired release profiles of loaded particles in the later stage. This is achieved by identifying the key parameters involved in particle production and understanding how adapting these parameters affects the final characteristics of particles. In this study, electrospraying was presented as a promising technique for generating reproducible particles made of polycaprolactone, a biodegradable, FDA-approved polymer. Narrow size distributions were obtained by the control of electrospraying flow rate and polymer concentration, with average particle sizes ranging from 10 to 20 µm. Particles were shown to be spherical with a homogeneous embossed OPEN ACCESSPolymers 2011, 3 132 texture, determined by the polymer entanglement regime taking place during electrospraying. No toxic residue was detected by this process based on preliminary cell work using DNA quantification assays, validating this method as suitable for further loading of bioactive components.

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Section: Microsphere Productionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Electrospraying, a Reproducible Method for Production of Polymeric Microspheres for Biomedical Applications

2011

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“…22 Size polydispersity of particles is a constraint limiting the potential application of micro/nanoparticles, eg, in the inhalable drug-delivery system, where the aerosol particles with homogeneous size and suitable aerodynamic diameter (1-5 µm) are essential. 25 Besides, the dissolution rate of a drug is dependent on the size of both drug and its carrier. Thus, drug absorption/bioavailability in the body could be properly regulated by particle-size modulation, 31 while the particle cellular uptake is influenced by the size of the polymeric particles.…”

Section: Electrosprayingmentioning

confidence: 99%

Advances in drug delivery via electrospun and electrosprayed nanomaterials

Zamani¹,

Prabhakaran²,

Ramakrishna³

2013

IJN

203

104

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Electrohydrodynamic (EHD) techniques refer to procedures that utilize electrostatic forces to fabricate fibers or particles of different shapes with sizes in the nano-range to a few microns through electrically charged fluid jet. Employing different techniques, such as blending, surface modification, and coaxial process, there is a great possibility of incorporating bioactive such molecules as drugs, DNA, and growth factors into the nanostructures fabricated via EHD techniques. By careful selection of materials and processing conditions, desired encapsulation efficiency as well as preserved bioactivity of the therapeutic agents can be achieved. The drug-loaded nanostructures produced can be applied via different routes, such as implantation, injection, and topical or oral administration for a wide range of disease treatment. Taking advantage of the recent developments in EHD techniques like the coaxial process or multilayered structures, individually controlled delivery of multiple drugs is achievable, which is of great demand in cancer therapy and growth-factor delivery. This review summarizes the most recent techniques and postmodification methods to fabricate electrospun nanofibers and electrosprayed particles for drug-delivery applications.

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“…Electrospray could be a mild method for preparing nano/ microcapsules by this kind of polymers. Electrospray has been applied for encapsulation of therapeutic and bioactive molecules such as antibiotics [8] anti-cancer agents [9] growth factors [2] Enzymes [10]. Also for encapsulation of adenoviruses (Ad) for the local delivery of Ad to target sites at a high concentration and subsequent enhancement of the therapeutic efficiency of Ad for cancer treatment [11].…”

Section: Introductionmentioning

confidence: 99%

Electrohydrodynamic Atomization Assisted Encapsulation of Bioactive Compounds

Nikoo¹

2015

MOJFPT

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Electrohydrodynamic atomization of quasi-monodisperse drug-loaded spherical/wrinkled microparticles

Cited by 87 publications

References 44 publications

Electrospraying, a Reproducible Method for Production of Polymeric Microspheres for Biomedical Applications

Electrospraying, a Reproducible Method for Production of Polymeric Microspheres for Biomedical Applications

Advances in drug delivery via electrospun and electrosprayed nanomaterials

Electrohydrodynamic Atomization Assisted Encapsulation of Bioactive Compounds

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