Electrohydrodynamic Atomization Assisted Encapsulation of Bioactive Compounds

Nikoo, Alireza Mehregan

doi:10.15406/mojfpt.2015.01.00010

Cited by 3 publications

(2 citation statements)

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“…Electrospraying is a method of atomizing a liquid or polymeric solution by applying electrostatic forces stronger than its surface tension [7,8]. In this process a liquid droplet at the tip of a capillary nozzle once exposed to a high electric field, undergoes a shape deformation to a cone, due to internal electrostatic repulsions and external attractive Coulombic forces, from which a jet is emitted that subsequently breaks up into fine droplets [7] as a result of varicose instability [9].…”

Section: Introductionmentioning

confidence: 99%

Electrospray-assisted encapsulation of caffeine in alginate microhydrogels

Nikoo¹,

Kadkhodaee²,

Ghorani³

et al. 2018

International Journal of Biological Macromolecules

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One of the major challenges with microencapsulation and delivery of low molecular weight bioactive compounds is their diffusional loss during storage and process conditions as well as under gastric conditions. In an attempt to slow down the release rate of core material, electrospray fabricated calcium alginate microhydrogels were coated with low molecular weight and high molecular weight chitosans. Caffeine as a hydrophilic model compound was used due to its several advantages on human behavior especially increasing consciousness. Mathematical modeling of the caffeine release by fitting the data with Korsmeyer-Peppas model showed that Fick's diffusion law could be the prevalent mechanism of the release. Electrostatic interaction between alginate and chitosan (particularly in the presence of 1% low molecular weight chitosan) provided an effective barrier against caffeine release and significantly reduced swelling of particles compared to control samples. The results of this study demonstrated that calcium alginate microhydrogels coated by chitosan could be used for encapsulation of low molecular compounds. However, more complementary research must be done in this field. In addition, electrospray, by producing monodisperse particles, would be as an alternative method for fabrication of microparticles based on natural polymers.

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Section: Introductionmentioning

confidence: 99%

Electrospray-assisted encapsulation of caffeine in alginate microhydrogels

Nikoo¹,

Kadkhodaee²,

Ghorani³

et al. 2018

International Journal of Biological Macromolecules

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“…For the fabrication of multilayered capsules, various technologies have been studied, including coaxial nozzle (or compound nozzle)-based dripping and jetting [6][7][8][9][10][11][12][13], droplet collision [14], and bulk emulsification by utilizing stirring/mixing [15]. During compound or coaxial nozzle-based fabrication, coaxial nozzles are used to produce the core droplet surrounded by a shell.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Double-Layered Alginate Capsules Using Coaxial Nozzle

Jin

Zhao

Huang

2017

Journal of Micro and Nano-Manufacturing

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Multilayered encapsulation has been of great interest for various pharmaceutical, chemical, and food industries. Fabrication of well-defined capsules with more than one shell layer still poses a significant fabrication challenge. This study aims to investigate the feasibility of using a coaxial nozzle to fabricate double-layered (core–shell–shell) capsules during vibration-assisted dripping. A three-layered coaxial nozzle has been designed, manufactured, and tested for double-layered capsule fabrication when using sodium alginate solutions as the model liquid material for inner and outer shell layers and calcium chloride solution as the core fluid. To facilitate the droplet formation process, a vibrator has been integrated into the fabrication system to provide necessary perturbation for effective breakup of the fluid flow. It is demonstrated that double-layered alginate capsules can be successfully fabricated using the proposed three-layered coaxial nozzle fabrication system. During fabrication, increasing the core flow rate leads to an increase in capsule and core diameters while the inner and outer shell layer thicknesses decrease. Increasing annular flow rate results in an increase in capsule diameter and inner shell layer thickness while the outer shell layer thickness decreases. An increase in the sheath flow rate leads to an increase in capsule diameter and outer shell layer thickness but has no significant effect on the core diameter and inner shell layer thickness.

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