Electrographic seizures in neonates correlate with poor neurodevelopmental outcome

McBride, Margaret C.; Laroia, Nirupama; Guillet, Ronnie

doi:10.1212/wnl.55.4.506

Cited by 335 publications

(223 citation statements)

References 42 publications

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“…[1][2][3] Thus, determination of etiology is critical, because it gives the opportunity to treat and to make a meaningful statement about the prognosis. [3][4][5] Nowadays, NS is defined by video -electroencephalographic monitoring, by clinical observation associated to ictal or interictal electroencephalogram (EEG), by electrographic discharge without associated clinical manifestation or by neonatal polysomnography 4,[6][7][8][9][10][11][12] . However, in clinical practice at the pediatric or neonatal intensive care units (ICU), in developing countries where synchronized video-EEG monitoring is practically nonexistent, clinical observation becomes the key to the diagnosis 3 .…”

Section: Introductionmentioning

confidence: 99%

Clinicoetiological profile and outcome of neonatal seizures

Sudia

Berwal

Nagaraj

et al. 2015

Int J Contemp Pediatr

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Section: Introductionmentioning

confidence: 99%

Clinicoetiological profile and outcome of neonatal seizures

Sudia

Berwal

Nagaraj

et al. 2015

Int J Contemp Pediatr

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“…Along with the revised background pattern and SWC classification, Hellström-Westas et al 13 29 but the treatment of subclinical seizures remains unclear. 30 Clinical studies are currently being undertaken to determine whether the treatment of EEG-detected seizures improves mortality and neurodevelopmental outcome.…”

Section: Introductionmentioning

confidence: 99%

Using amplitude-integrated EEG in neonatal intensive care

Tao

Mathur

2010

J Perinatol

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The implementation of amplitude-integrated electroencephalography (aEEG) has enhanced the neurological monitoring of critically ill infants. Limited channel leads are applied to the patient and data are displayed in a semilogarithmic, time-compressed scale. Several classifications are currently in use to describe patient tracings, incorporating voltage criteria, pattern recognition, cyclicity, and the presence or absence of seizures. In term neonates, aEEG has been used to determine the prognosis and treatment for those affected by hypoxic-ischemic encephalopathy, seizures, meningitis and even congenital heart disease. Its application as inclusion criteria for therapeutic hypothermia remains controversial. In preterm infants, normative values and patterns corresponding to gestational age are being established. As these standards emerge, the predictive value of aEEG increases, especially in the setting of preterm brain injury and intraventricular hemorrhage. The sensitivity and specificity of aEEG are enhanced by the display of a simultaneous raw EEG, which aids interpretation. Caution must be taken when using and interpreting this tool in conjunction with certain medications and in the setting of less experienced staff. Continuing efforts at developing software that can aid seizure detection and background classification will enhance the bedside utility of this tool.

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“…[4][5][6][7] Clinical NSs have been correlated with significant neurological morbidity and mortality. 7,8 Because of the concern for missing difficult to recognize or frankly subclinical electrographic NSs, diagnostic monitoring tools are increasingly used in intensive care units for high-risk neonates.…”

Section: Introductionmentioning

confidence: 99%

Limitations of single-channel EEG on the forehead for neonatal seizure detection

2008

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Objectives: In amplitude-integrated EEG, lead placement across the forehead is convenient, but this location has unknown effects on neonatal seizure (NS) detection sensitivity. This study describes the limits of NS detection by a single forehead EEG channel.Study Design: Records were taken from a digital library of conventional EEGs (CEEGs) with NS, previously characterized at a bicentral channel, C 3 -C 4 . We analyzed electrographic characteristics in a single forehead channel, Fp 3 -Fp 4 .Result: A total of 330 seizures from 125 CEEGs were included. With Fp 3 -Fp 4 , at least one NS was detected in 66% of records vs 90% using C 3 -C 4 (P<0.0001). Of 330 seizures, 46% appeared in Fp 3 -Fp 4 vs 73% in C 3 -C 4 (P<0.0001). Seizures appeared briefer in Fp 3 -Fp 4 than C 3 -C 4 (P<0.006) and CEEG (P<0.0001). Conclusion:NSs are significantly more difficult to detect with a single forehead channel than bicentrally or on CEEG. In Fp 3 -Fp 4 , a third of records with seizures were missed and over half of seizures were undetected.

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Electrographic seizures in neonates correlate with poor neurodevelopmental outcome

Cited by 335 publications

References 42 publications

Clinicoetiological profile and outcome of neonatal seizures

Clinicoetiological profile and outcome of neonatal seizures

Using amplitude-integrated EEG in neonatal intensive care

Limitations of single-channel EEG on the forehead for neonatal seizure detection

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