Electroencephalographic Sleep Profiles Before and After Cognitive Behavior Therapy of Depression

Thase, Michael E.; Fasiczka, Amy L.; Berman, Susan R.; Simons, Anne D.; Reynolds, Charles F.

doi:10.1001/archpsyc.55.2.138

Cited by 104 publications

(45 citation statements)

References 55 publications

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“…More convincingly, there is a striking similarity between the EEG activity of depressives and abstinent psychostimulant abusers during sleep. One of the more reliable physiological markers of MDD has been a characteristic disruption of the normal architecture of the nocturnal EEG, reflected in reduced REM latency and increased REM density throughout the night (Kupfer et al, 1976;Thase et al, 1998;Landolt and Gillin, 2002). Abstinence from both amphetamine (Watson et al, 1972) and cocaine (Thompson et al, 1995) mimics the effects of MDD on these parameters.…”

Section: Psychostimulant Withdrawal In Humans-physiological Effectsmentioning

confidence: 99%

Psychostimulant withdrawal as an inducing condition in animal models of depression

Barr

Markou

2005

Neuroscience & Biobehavioral Reviews

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Section: Psychostimulant Withdrawal In Humans-physiological Effectsmentioning

confidence: 99%

Psychostimulant withdrawal as an inducing condition in animal models of depression

Barr

Markou

2005

Neuroscience & Biobehavioral Reviews

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“…Antidepressant treatments restore normal cycles of mood (Jouvent et al, 1998), REM sleep (Thase et al, 1998), EEG y frequencies (Knott et al, 1996), rest-activity cycles (Raoux et al, 1994;Duncan et al, 1998), and hormonal rhythms (see review, Duncan, 1986). To test a hypothesis that ultradian neurochemical rhythms would be affected by antidepressants, CSF samples at 10-min intervals for 24 h were collected from depressed patients and examined for changes in spectral (oscillatory frequency) features before and after antidepressant treatment.…”

Section: Introductionmentioning

confidence: 99%

Treatment Enhances Ultradian Rhythms of CSF Monoamine Metabolites in Patients with Major Depressive Episodes

Salomon

Kennedy

Johnson

et al. 2005

Neuropsychopharmacol

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Unipolar and bipolar depressions show abnormal behavioral manifestations of ultradian (less than 24 h) rhythms, but abnormal rhythms of the central neurotransmitters thought to be important for depression pathophysiology (eg dopamine (DA) and serotonin (5-HT)) have not been shown in this time frame. Since antidepressant treatments normalize disrupted rhythms in depression (eg rapid-eyemovement sleep and hormonal rhythms), we hypothesized that depression-related changes in ultradian oscillations of DA and 5-HT might be revealed during antidepressant treatment. Cerebrospinal fluid (CSF) samples collected q10 min for 24 h in 13 patients experiencing major depressive episodes (MDE) before and after treatment for 5 weeks with sertraline or bupropion were assayed for levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), and their ratio was calculated. Data were analyzed in the frequency domain using Fourier transforms and multivariate permutation testing. Antidepressant treatments were associated with decreased variance for 5-HIAA, increased variance for HVA, and markedly increased variance for the HVA : 5-HIAA ratio (po0.05, po0.02, and po0.003, respectively). With treatment, the correlations between 5-HIAA and HVA weakened (p ¼ 0.06). Power spectral density (PSDFthe Fourier magnitude squared) of the 5-HIAA signals at periods of 1.75 and 3.7 h (both po0.05) decreased, while circadian cycling of HVA levels (po0.05) and of the ratio (po0.005) increased after treatment. The PSD of the full-length HVA : 5-HIAA ratio series after treatment increased in rapid variability (20-103 min periods, po0.05). Spectrographic windowing demonstrated a focal span of enhanced HVA : 5-HIAA ratio variability following antidepressant treatment, in an approximately 84-min period through the evening (po0.05). Periodic neurotransmitter relationships in depressed patients were altered by treatment in this analysis of a small data set. This may represent a baseline abnormality in the regulation of periodic functions involved in the depression pathophysiology, but it could also be due to an unrelated antidepressant effect. Further studies including comparisons with healthy subject data are in progress.

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“…CBT has significant effects on brain functioning and other biological processes. Moreover, CBT can influence electroencephalographic sleep profiles, 106 thyroid hormone levels, 107 and multiple brain pathways for the processing of cognition and emotion. 108,109…”

Section: Discussionmentioning

confidence: 99%

Support management in schizophrenia: a systematic review of current literature

Pompili¹,

Montebovi²,

Forte³

et al. 2012

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Background: Schizophrenia is generally considered a chronic disorder characterized by psychotic symptoms and relatively stable neurocognitive and interpersonal deficits. Antipsychotic medication has proven beneficial in reducing psychotic symptoms, but is often not enough to treat cognitive or functional impairments. Residual cognitive impairments are barriers to a patient's full recovery from schizophrenia. Rehabilitation is an alternative and important approach which may be useful, and encompasses a variety of treatments including social skills training and psychoeducational and cognitive behavioral treatments. Objective: To investigate the efficacy of psychosocial treatments in schizophrenia, evaluating its effects in the short and long term, comparing psychosocial treatments with pharmacotherapy, and assessing the effects of treatment and the main indications for use in patients with schizophrenia. Methods: A careful MEDLINE ® , Excerpta Medica, PsycLIT ® , PsycINFO ® , and IndexMedicus search was performed to identify all papers and book chapters in English for the period 1970-2012. Results:Findings from the studies included in this qualitative analysis suggest that social skills therapy, cognitive behavioral therapy, family intervention therapy, cognitive remediation therapy, and other nonpharmacological therapeutic strategies may be beneficial for patients with significant functional and symptomatic impairments. Conclusion: Schizophrenic patients treated with nonpharmacological techniques have more rapid remission and relapse less frequently than patients treated only pharmacologically.

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Electroencephalographic Sleep Profiles Before and After Cognitive Behavior Therapy of Depression

Cited by 104 publications

References 55 publications

Psychostimulant withdrawal as an inducing condition in animal models of depression

Psychostimulant withdrawal as an inducing condition in animal models of depression

Treatment Enhances Ultradian Rhythms of CSF Monoamine Metabolites in Patients with Major Depressive Episodes

Support management in schizophrenia: a systematic review of current literature

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