Electroencephalographic findings in hyperthyroidism

Olsen, P. Zander; Støier, M; Siersbæk-Nielsen, K; Hansen, Jens Mølholm; Schioler, M; Kristensen, M

doi:10.1016/0013-4694(72)90139-3

Cited by 20 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A report of EEG abnormalities in hyperthyroids (Olsen et al, 1972) is consistent with our data, suggesting initial general cerebral dysfunction, followed by decrease in Ebnormality associated with improved tests of thyroid function. Often the EEG abnormalities diminished gradually and incompletely, which may parallel more closely the slower improvement in reported psychological well-being, even though cognitive deficits are less readily identifiable.…”

Section: Discussionsupporting

confidence: 92%

“…Scores on two measures of cognitive func-tion initially resembled those of persons with known brain damage and subsequently fell within normal limits, findings similar to those of Robbins and Vinson (1960), who questioned the emphasis that has been placed on personality factors in the etiology of hyperthyroidism. Olsen et al (1972) reported that the degree of electroencephalogram (EEG) abnormality bore a positive relation to the severity of hyperthyroidism during acute stages of the illness and that significantly reduced EEG evidence of cortical dysfunction was observed following treatment. They noted that the return to EEG normality was gradual and as yet incomplete in the majority of patients 1 year after treatment, suggesting that subtle organic effects of thyroid toxicity persisted for a significant period of time and that reported follow-up evaluations of hyperthyroid patients may have been made before clinical recovery was complete.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Acute hyperthyroidism: Cognitive and emotional correlates.

Wallace¹,

MacCrimmon²,

Goldberg³

1980

Journal of Abnormal Psychology

View full text Add to dashboard Cite

The nature of cognitive disturbance and psychological distress was evaluated in 19 acutely hyperthyroid women and in 19 demographically comparable women with normal thyroid function. A structured psychiatric interview, the Minnesota Multiphasic Personality Inventory, and a battery of brief repeatable tests of motor speed, attention, selective attention, and short-term verbal memory were employed prior to treatment with radioactive iodine, 3 weeks later, and 6-12 months later when normal thyroid function was established. Thyroid-normal women were similarly evaluated. Multiple regression analysis revealed not only cognitive deficits consistent with central nervous system toxicity but also a classic neurotic picture strongly associated with severity of pretreatment thyroid toxicity, measured by serum thyroxin (T 4 ). The relation between T 4 and cognitive deficits was not apparent 3 weeks later, but the relation between T 4 and a neurotic picture persisted. Final evaluation showed no relation between cognitive or personality function and earlier hyperthyroidism. Results suggest that the effects of thyroid toxicity are reflected in symptoms of neurotic emotional disturbance that may be transient rather than indicative of personality traits.Early psychiatric writing about hyperthyroidism emphasized psychodynamic factors thought to contribute to the development of thyroid disorder. Hyperthyroid patients, the majority of whom were female, were found on psychiatric evaluation to have similar personality features, which often included inability to express or cope

show abstract

Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Acute hyperthyroidism: Cognitive and emotional correlates.

Wallace¹,

MacCrimmon²,

Goldberg³

1980

Journal of Abnormal Psychology

View full text Add to dashboard Cite

show abstract

“…The regression of seizures, the normalization of the EEG only after antithyroid medication, as some authors have already reported [5,9,10], and the follow-up sug gest a causal connection between seizures and thyrotoxi cosis.…”

Section: Discussionmentioning

confidence: 84%

Thyrotoxic Encephalopathy and Recurrent Seizures

Primavera

Brusa

Novello³

1990

Eur Neurol

View full text Add to dashboard Cite

Epilepsy is a rare but possible manifestation of thyrotoxicosis. The patient reported here developed recurrent, generalized and focal seizures, as presenting symptoms of a thyrotoxic encephalopathy. Intercritic EEG records showed triphasic waves. Seizures and signs of encephalopathy disappeared and the EEG reverted to normal only after treatment of the thyroid hyperfunction. It is concluded that thyroid function should be evaluated in cases of otherwise unexplained encephalopathy with untreatable seizures and triphasic waves.

show abstract

“…The EEGresponse to intermittent photic stimulation was augmented in thyrotoxic patients, who reported that this stimulation was very disagreeable (Wilson & Johnson, 1964). After treatment, EEG patterns returned to normal in nearly all patients (Olsen et al, 1972;Wilson & Johnson, 1964). However, EEG abnormalities appear not to be correlated with the severity of thyrotoxicosis (Olsen et al, 1972;Skanse & Nyman, 1956).…”

Section: Hyperthyroidismmentioning

confidence: 99%

“…After treatment, EEG patterns returned to normal in nearly all patients (Olsen et al, 1972;Wilson & Johnson, 1964). However, EEG abnormalities appear not to be correlated with the severity of thyrotoxicosis (Olsen et al, 1972;Skanse & Nyman, 1956). The incidence of EEG abnormalities has been reported to be greater in young females than in postmenopausal women or men (Wilson & Johnson, 1964).…”

Section: Hyperthyroidismmentioning

confidence: 99%

Thyroid Disorders

Beckwith¹

2001

Medical Neuropsychology

View full text Add to dashboard Cite

provide reviews of the thyroid axis and its disorders. The thyroid gland in the human consists of two lateral lobes (connected by an isthmus) that lie over the trachea below the cricoid cartilage and is one of the largest endocrine glands, weighing about 20-30 g in an adult. Arterial blood is supplied by the superior thyroid artery,' arising from the external carotid arteries, and the inferior, arising from the subclavian arteries. Autonomic innervation is provided by both adrenergic and cholinergic neurons arising from the cervical ganglia and the vagus nerve , respectively. Neurogenic-adrenergic innervation regulates blood flow through the gland in addition to acting directly at the level of the follicle cell . Synthesis and Metabolism of Thyroid HormonesSynthesis of thyroid hormones is dependent on the availability of adequate quantities of exogenous iodine. Iodine is provided by inorganic iodide from the diet, iodide leak (passive loss of iodide from the thyroid into the blood), and peripheral deiodination of thyroid hormones. Iodide is concentrated in extracellular fluid , from which it is drawn during the synthesis of thyroid hormones. Iodide is stored in red blood cells and intraluminal fluids such as saliva and gastric juice and is cleared predominately through the thyroid and kidney, which reabsorbs iodide passively and is not considered as sharing in thyroid homeostasis. The major channel for removal of iodide from extracellular fluid is the thyroid gland. The thyroid gland is unique among endocrine glands in that it has a large store of hormone and a slow rate of turnover. This large reservoir (about 100 days of the average output of the thyroid gland) provides extended protection against depletion of circulating thyroid hormone in the event of termination of synthesis of th yroid hormones. BILL E. BECKWITH • She ll Point Retir ement Comm unity. Fort Myers, Florida 33908.

show abstract

Electroencephalographic findings in hyperthyroidism

Cited by 20 publications

References 5 publications

Acute hyperthyroidism: Cognitive and emotional correlates.

Acute hyperthyroidism: Cognitive and emotional correlates.

Thyrotoxic Encephalopathy and Recurrent Seizures

Thyroid Disorders

Contact Info

Product

Resources

About