ABSTRACT. The effects of xylazine or medetomidine on tiletamine/zolazepam (Zoletile ® ) anesthesia were evaluated by changes in the canine electroencephalogram (EEG). Experimental groups were three: the group treated with 10 mg/kg of Zoletile intravenously (TZ), the group treated with 1.1 mg/kg of xylazine intramuscularly and 10 mg/kg of Zoletile intravenously (XTZ), and the group treated with 30 µg/kg of medetomidine intramuscularly and 10 mg/kg of Zoletile intravenously (MTZ). EEG recording electrode was positioned at Cz, which was applied to International 10-20 system. For all recording times, the powers of each band (band 1: 1-2.5 Hz, band 2 : 2.5-4.5 Hz, band 3: 4.5-8 Hz, band 4: 8-13 Hz, band 5: 13-20 Hz, band 6: 20-30 Hz, band 7: 30-50 Hz, band 8: 1-50 Hz) were calculate d. In TZ, at 10 min after Zoletile injection, the powers of bands 3, 4, 5 and 8 significantly decreased. At 20 min after Zoletile injection, the powers of band 1 and 8 were significantly decreased. After Zoletile injection, there were significant decreases in bands 1, 4, 5, 6, 7 and 8 in XTZ, and in bands 1, 3, 4, 5, 6, 7 and 8 in MTZ. These significant changes disappeared in all band powers in TZ and MTZ in the last 1 min just prior to the dogs showing head-up movement. But, in XTZ, all band powers, except band 2, were significantly reduced. EEG power spectral analysis revealed the differences in band powers on awakening, even though the same kind of drugs w ere used. We thought that was a useful method to compare the effect of xylazine and medetomidine on Zoletile-induced anesthesia in dogs.