Electrodialytic sample treatment coupled on-line with high-performance liquid chromatography

Debets, A.J.J.; Kok, Wim Th.; Hupe, K. P.; Brinkman, U.A.Th.

doi:10.1007/bf02328498

Cited by 29 publications

(11 citation statements)

References 13 publications

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“…Obviously, for an EDIST cell with equal donor and acceptor volumes and b = 0.06 cm, the required residence time for an analyte is about 0.5-1.5 min. These findings are supported by experimental results described previously [19,20]. Using a stagnant accept0f phase and a flowing donor (sample) phase in a home" made electrodialysis cell, the analyte recovery arid enrichment were studied.…”

Section: I T (1 -+ (1 -T;)supporting

confidence: 84%

“…These results are in fairly good agree" ment with the minimum residence times reported i~ Table II -for realistic values of t + and t;, a residence time of about 1 min will generally be sufficient to achieve quantitative transfer of the analyte into the acceptor phase. The results of these computer simula" tions have been confirmed in practical experiments [19]. Using donor flow rates of 25 gl rain-1 (approx.…”

Section: (E)mentioning

confidence: 55%

“…Using the basic drug ephe" drine, maximum recovery (and enrichment) was oh" tained when the residence time of the drug in the donO~ compartment was 1 min; i.e. with a donor compartme~ t volume of 25 gl (donor and acceptor compartment volume each 25 ~tl; b = 0.06) the optimum donor fin w: rate was 25 gl min -1 [19]. Decreasing the residence time by increasing the donor flow rate to 50 or evO a 75 gl min-1 decreased the analyte recovery.…”

Section: I T (1 -+ (1 -T;)mentioning

confidence: 99%

“…Figure 4 shows the results of simulations of a flowing donor and a stagnant acceptor solution. The geometry of the cell in the simulation study was equal to that of the cell used in practice before [19,20], with a channel height of 0.03 cm for both the donor and acceptor compartment. The analyte was assumed to have a diffusion coefficient of 5 10 -6 cm 2 s -1 and a ionic mobility of 2 10 -4 cm 2 V-1 s-1.…”

Section: Computer Simulationsmentioning

confidence: 99%

“…In previously published studies [19,20] we have shown that electrodialysis can be used in practice as an on-line sample treatment method for LC. With electrodialytiC sample treatment (EDIST), traces of analytes could be enriched from the sample solution.…”

Section: Introductionmentioning

confidence: 99%

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Theoretical models for electrodialytic sample treatment in trace analysis by liquid chromatography

et al. 1994

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Theoretical models for electrodialytic sample treatment in trace analysis by liquid chromatography. Debets, A.J.J.; van Wier, P.; Brinkman, U.A.Th.; Kok, W.T. Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Key WordsColumn liquid chromatography Electrodialytic sample treatment Computer models Analyte enrichment SummaryBasic considerations for analyte enrichment and recovery obtainable by electrodialysis as a sample treatment method are given. Equations are derived which describe the dependence of the concentration profiles of ionic compounds on the electric field strength in a set-up with stagnant donor and acceptor solutions. It is shown that analyte recovery increases when less ion-selective membranes are used in the electrodialysis cell. Computer models are used to estimate the analyte enrichment for a flowing donor (sample) and a stagnant acceptor phase. About 10-fold enrichment can be obtained in an electrodialytic sample treatment system within 20 min under maximum current conditions. A compromise has to be found between analyte recovery and the donor (sample) flow rate.

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Section: I T (1 -+ (1 -T;)supporting

confidence: 84%

Section: (E)mentioning

confidence: 55%

Section: I T (1 -+ (1 -T;)mentioning

confidence: 99%

Section: Computer Simulationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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