Theoretical models for electrodialytic sample treatment in trace analysis by liquid chromatography

Abstract

Theoretical models for electrodialytic sample treatment in trace analysis by liquid chromatography. Debets, A.J.J.; van Wier, P.; Brinkman, U.A.Th.; Kok, W.T. Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Key WordsColumn liquid chromatography Electrodialytic sample treatment Computer models Analyte enrichment SummaryBasic considerations for analyte enrichment and recovery obtainable by electrodialysis as a sample treatment method are given. Equations are derived which describe the dependence of the concentration profiles of ionic compounds on the electric field strength in a set-up with stagnant donor and acceptor solutions. It is shown that analyte recovery increases when less ion-selective membranes are used in the electrodialysis cell. Computer models are used to estimate the analyte enrichment for a flowing donor (sample) and a stagnant acceptor phase. About 10-fold enrichment can be obtained in an electrodialytic sample treatment system within 20 min under maximum current conditions. A compromise has to be found between analyte recovery and the donor (sample) flow rate.

Electric field‐enhanced transport across phase boundaries and membranes and its potential use in sample pretreatment for bioanalysis

“…Theoretical considerations on ED sample pretreatment in trace analyses were comprehensively described by Debets et al [61]. Theoretical models were developed for experimental setups with stagnant and dynamic donor phases and final conclusions were drawn reflecting the fact that highest possible recovery and preconcentration factors should be achieved.…”

Feasibility of electrodialysis as a fast and selective sample preparation method for the profiling of low‐abundant peptides in biofluids

“…Assuming that the membrane has no influence on the transport of the analytes, their flux (J, mol/s/m 2 ) through the membrane is described by the Nernst-Planck equation [9,19]:…”

Why liquid membrane extraction is an attractive alternative in sample preparation

“…With a flowing feed solution and stagnant receiving phase, additional selectivity and enrichment of charged analytes can be obtained. The basic principles of electrodialysis for trace analysis have been reviewed by Debets et al [19]. It has its own limitations such as limited enrichment factors, pH change in the feed during extraction, and thermal degradation of the membrane at high potential [31].…”

“…For the first, a special journal issue devoted to the use of membrane-based extractions in analytical chemistry was published [17]. An area enjoying much attention by various research groups is developing membrane-based extraction techniques that are simple, cheap, and miniaturized [18][19][20][21][22][23][24][25][26][27][28].…”