Electrodeposition iron target for the cyclotron production of 55Co in labeling proteins

Mirzaii, M.; Kakavand, T.; Talebi, M.; Rajabifar, S.

doi:10.1007/s10967-011-1399-x

Cited by 8 publications

(3 citation statements)

References 19 publications

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“…It has a half-life of 17.5 hours, a positron branching ratio of 77%, and an average positron energy of 570 keV, qualities that make it well suited for imaging with peptides, small molecules, and antibodies. 6–11 55 CoCl 2 has previously been used clinically to image ischemia in stroke patients 12–15 and in late-onset epileptic seizures 16 due to its ability to mimic calcium uptake. However, it is important to study the preclinical pharmacologic properties of this isotope when it will be incorporated into targeting ligands as imaging agents to probe other diseases.…”

mentioning

confidence: 99%

Cyclotron Production of High–Specific Activity ⁵⁵ Co and In Vivo Evaluation of the Stability of ⁵⁵ Co Metal-Chelate-Peptide Complexes

et al. 2015

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This work describes the production of high-specific activity 55Co and the evaluation of the stability of 55Co-metal-chelate-peptide complexes in vivo. 55Co was produced via the 58Ni(p,α)55Co reaction and purified using anion exchange chromatography with an average recovery of 92% and an average specific activity of 1.96GBq/µmol. 55Co-DO3A and 55Co-NO2A peptide complexes were radiolabelled at 3.7MBq/µg and injected into HCT-116 tumor xenografted mice. PET imaging and biodistribution studies were performed at 24 and 48 hours post injection and compared with that of 55CoCl2. Both 55Co-metal-chelate complexes demonstrated good in vivo stability by reducing the radiotracers’ uptake in the liver by 6-fold at 24 with ~1% ID/g and at 48 hours with ~0.5% ID/g, and reducing uptake in the heart by 4-fold at 24 hours with ~0.7% ID/g and 7-fold at 48 hours with ~0.35% ID/g. These results support the use of 55Co as a promising new radiotracer for Positron Emission Tomography (PET) imaging of cancer and other diseases.

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confidence: 99%

Cyclotron Production of High–Specific Activity ⁵⁵ Co and In Vivo Evaluation of the Stability of ⁵⁵ Co Metal-Chelate-Peptide Complexes

et al. 2015

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“…Chelating agent effect on the imaging efficiency was investigated by taking PET/CT images at 2 hours p.i. of [76,79,176,[178][179][180][181][182]. The results showed that both 55 Co-radiofolates displayed higher tumor 68 Ga and 64 Cu-analogs.…”

Section: Fa(γ)mentioning

confidence: 95%

Folate-based radiotracers for nuclear imaging and radionuclide therapy

Wagner

Kenzhebayeva

Dhaini

et al. 2022

Coordination Chemistry Reviews

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“…Its rotating direction is reversed after each 8 s improving deposit homogeneity. To keep the desired temperature at a preset level, a heater together with a sensor is circularly mounted at the bottom of the vessel (Mirzaii et al, 2012).…”

Section: Methodsmentioning

confidence: 99%

Nuclear model calculation and targetry recipe for production of 110mIn

Kakavand

Mirzaii²,

Eslami

et al. 2015

Applied Radiation and Isotopes

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Electrodeposition iron target for the cyclotron production of 55Co in labeling proteins

Cited by 8 publications

References 19 publications

Cyclotron Production of High–Specific Activity ⁵⁵ Co and In Vivo Evaluation of the Stability of ⁵⁵ Co Metal-Chelate-Peptide Complexes

Cyclotron Production of High–Specific Activity ⁵⁵ Co and In Vivo Evaluation of the Stability of ⁵⁵ Co Metal-Chelate-Peptide Complexes

Folate-based radiotracers for nuclear imaging and radionuclide therapy

Nuclear model calculation and targetry recipe for production of 110mIn

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Electrodeposition iron target for the cyclotron production of 55Co in labeling proteins

Cited by 8 publications

References 19 publications

Cyclotron Production of High–Specific Activity 55 Co and In Vivo Evaluation of the Stability of 55 Co Metal-Chelate-Peptide Complexes

Cyclotron Production of High–Specific Activity 55 Co and In Vivo Evaluation of the Stability of 55 Co Metal-Chelate-Peptide Complexes

Folate-based radiotracers for nuclear imaging and radionuclide therapy

Nuclear model calculation and targetry recipe for production of 110mIn

Contact Info

Product

Resources

About

Cyclotron Production of High–Specific Activity ⁵⁵ Co and In Vivo Evaluation of the Stability of ⁵⁵ Co Metal-Chelate-Peptide Complexes

Cyclotron Production of High–Specific Activity ⁵⁵ Co and In Vivo Evaluation of the Stability of ⁵⁵ Co Metal-Chelate-Peptide Complexes